SARS-CoV-2 inhibits induction of the MHC class I pathway by targeting the STAT1-IRF1-NLRC5 axis

The presentation of viral antigens to T cells via the MHC molecules is a critical component of the host response to viral infection. Here the authors suggest SARS-CoV-2 possesses the immune evasion strategy against the MHC class I pathway by targeting key transcriptional regulators.

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Autores principales:	Ji-Seung Yoo, Michihito Sasaki, Steven X. Cho, Yusuke Kasuga, Baohui Zhu, Ryota Ouda, Yasuko Orba, Paul de Figueiredo, Hirofumi Sawa, Koichi S. Kobayashi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/985ec8dc38ab4bd98cffc38c5682e3e9
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spelling	oai:doaj.org-article:985ec8dc38ab4bd98cffc38c5682e3e92021-11-21T12:35:47ZSARS-CoV-2 inhibits induction of the MHC class I pathway by targeting the STAT1-IRF1-NLRC5 axis10.1038/s41467-021-26910-82041-1723https://doaj.org/article/985ec8dc38ab4bd98cffc38c5682e3e92021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26910-8https://doaj.org/toc/2041-1723The presentation of viral antigens to T cells via the MHC molecules is a critical component of the host response to viral infection. Here the authors suggest SARS-CoV-2 possesses the immune evasion strategy against the MHC class I pathway by targeting key transcriptional regulators.Ji-Seung YooMichihito SasakiSteven X. ChoYusuke KasugaBaohui ZhuRyota OudaYasuko OrbaPaul de FigueiredoHirofumi SawaKoichi S. KobayashiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ji-Seung Yoo Michihito Sasaki Steven X. Cho Yusuke Kasuga Baohui Zhu Ryota Ouda Yasuko Orba Paul de Figueiredo Hirofumi Sawa Koichi S. Kobayashi SARS-CoV-2 inhibits induction of the MHC class I pathway by targeting the STAT1-IRF1-NLRC5 axis
description	The presentation of viral antigens to T cells via the MHC molecules is a critical component of the host response to viral infection. Here the authors suggest SARS-CoV-2 possesses the immune evasion strategy against the MHC class I pathway by targeting key transcriptional regulators.
format	article
author	Ji-Seung Yoo Michihito Sasaki Steven X. Cho Yusuke Kasuga Baohui Zhu Ryota Ouda Yasuko Orba Paul de Figueiredo Hirofumi Sawa Koichi S. Kobayashi
author_facet	Ji-Seung Yoo Michihito Sasaki Steven X. Cho Yusuke Kasuga Baohui Zhu Ryota Ouda Yasuko Orba Paul de Figueiredo Hirofumi Sawa Koichi S. Kobayashi
author_sort	Ji-Seung Yoo
title	SARS-CoV-2 inhibits induction of the MHC class I pathway by targeting the STAT1-IRF1-NLRC5 axis
title_short	SARS-CoV-2 inhibits induction of the MHC class I pathway by targeting the STAT1-IRF1-NLRC5 axis
title_full	SARS-CoV-2 inhibits induction of the MHC class I pathway by targeting the STAT1-IRF1-NLRC5 axis
title_fullStr	SARS-CoV-2 inhibits induction of the MHC class I pathway by targeting the STAT1-IRF1-NLRC5 axis
title_full_unstemmed	SARS-CoV-2 inhibits induction of the MHC class I pathway by targeting the STAT1-IRF1-NLRC5 axis
title_sort	sars-cov-2 inhibits induction of the mhc class i pathway by targeting the stat1-irf1-nlrc5 axis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/985ec8dc38ab4bd98cffc38c5682e3e9
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SARS-CoV-2 inhibits induction of the MHC class I pathway by targeting the STAT1-IRF1-NLRC5 axis

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