Exosomal cargo including microRNA regulates sensory neuron to macrophage communication after nerve trauma

Exosomes are known to contain microRNAs (miRs). Here the authors show that dorsal root ganglion neurons release exosomes containing miR-21-5p, which contributes to inflammatory cell recruitment following peripheral nerve injury.

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Autores principales:	Raffaele Simeoli, Karli Montague, Hefin R. Jones, Laura Castaldi, David Chambers, Jayne H. Kelleher, Valentina Vacca, Thomas Pitcher, John Grist, Hadil Al-Ahdal, Liang-Fong Wong, Mauro Perretti, Johnathan Lai, Peter Mouritzen, Paul Heppenstall, Marzia Malcangio
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/985f58856e554adfb658898c61646afe
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spelling	oai:doaj.org-article:985f58856e554adfb658898c61646afe2021-12-02T15:38:52ZExosomal cargo including microRNA regulates sensory neuron to macrophage communication after nerve trauma10.1038/s41467-017-01841-52041-1723https://doaj.org/article/985f58856e554adfb658898c61646afe2017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01841-5https://doaj.org/toc/2041-1723Exosomes are known to contain microRNAs (miRs). Here the authors show that dorsal root ganglion neurons release exosomes containing miR-21-5p, which contributes to inflammatory cell recruitment following peripheral nerve injury.Raffaele SimeoliKarli MontagueHefin R. JonesLaura CastaldiDavid ChambersJayne H. KelleherValentina VaccaThomas PitcherJohn GristHadil Al-AhdalLiang-Fong WongMauro PerrettiJohnathan LaiPeter MouritzenPaul HeppenstallMarzia MalcangioNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Raffaele Simeoli Karli Montague Hefin R. Jones Laura Castaldi David Chambers Jayne H. Kelleher Valentina Vacca Thomas Pitcher John Grist Hadil Al-Ahdal Liang-Fong Wong Mauro Perretti Johnathan Lai Peter Mouritzen Paul Heppenstall Marzia Malcangio Exosomal cargo including microRNA regulates sensory neuron to macrophage communication after nerve trauma
description	Exosomes are known to contain microRNAs (miRs). Here the authors show that dorsal root ganglion neurons release exosomes containing miR-21-5p, which contributes to inflammatory cell recruitment following peripheral nerve injury.
format	article
author	Raffaele Simeoli Karli Montague Hefin R. Jones Laura Castaldi David Chambers Jayne H. Kelleher Valentina Vacca Thomas Pitcher John Grist Hadil Al-Ahdal Liang-Fong Wong Mauro Perretti Johnathan Lai Peter Mouritzen Paul Heppenstall Marzia Malcangio
author_facet	Raffaele Simeoli Karli Montague Hefin R. Jones Laura Castaldi David Chambers Jayne H. Kelleher Valentina Vacca Thomas Pitcher John Grist Hadil Al-Ahdal Liang-Fong Wong Mauro Perretti Johnathan Lai Peter Mouritzen Paul Heppenstall Marzia Malcangio
author_sort	Raffaele Simeoli
title	Exosomal cargo including microRNA regulates sensory neuron to macrophage communication after nerve trauma
title_short	Exosomal cargo including microRNA regulates sensory neuron to macrophage communication after nerve trauma
title_full	Exosomal cargo including microRNA regulates sensory neuron to macrophage communication after nerve trauma
title_fullStr	Exosomal cargo including microRNA regulates sensory neuron to macrophage communication after nerve trauma
title_full_unstemmed	Exosomal cargo including microRNA regulates sensory neuron to macrophage communication after nerve trauma
title_sort	exosomal cargo including microrna regulates sensory neuron to macrophage communication after nerve trauma
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/985f58856e554adfb658898c61646afe
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Exosomal cargo including microRNA regulates sensory neuron to macrophage communication after nerve trauma

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