Dynamic regulation of GDP binding to G proteins revealed by magnetic field-dependent NMR relaxation analyses

Heterotrimeric guanine-nucleotide-binding proteins (G proteins) act as molecular switches. Here the authors use NMR relaxation analyses, which reveal the dynamics of G protein alpha subunit binding to GDP on a microsecond timescale.

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Autores principales:	Yuki Toyama, Hanaho Kano, Yoko Mase, Mariko Yokogawa, Masanori Osawa, Ichio Shimada
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/985f87fc49594e81ade0f518bf2a63de
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spelling	oai:doaj.org-article:985f87fc49594e81ade0f518bf2a63de2021-12-02T17:06:23ZDynamic regulation of GDP binding to G proteins revealed by magnetic field-dependent NMR relaxation analyses10.1038/ncomms145232041-1723https://doaj.org/article/985f87fc49594e81ade0f518bf2a63de2017-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms14523https://doaj.org/toc/2041-1723Heterotrimeric guanine-nucleotide-binding proteins (G proteins) act as molecular switches. Here the authors use NMR relaxation analyses, which reveal the dynamics of G protein alpha subunit binding to GDP on a microsecond timescale.Yuki ToyamaHanaho KanoYoko MaseMariko YokogawaMasanori OsawaIchio ShimadaNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yuki Toyama Hanaho Kano Yoko Mase Mariko Yokogawa Masanori Osawa Ichio Shimada Dynamic regulation of GDP binding to G proteins revealed by magnetic field-dependent NMR relaxation analyses
description	Heterotrimeric guanine-nucleotide-binding proteins (G proteins) act as molecular switches. Here the authors use NMR relaxation analyses, which reveal the dynamics of G protein alpha subunit binding to GDP on a microsecond timescale.
format	article
author	Yuki Toyama Hanaho Kano Yoko Mase Mariko Yokogawa Masanori Osawa Ichio Shimada
author_facet	Yuki Toyama Hanaho Kano Yoko Mase Mariko Yokogawa Masanori Osawa Ichio Shimada
author_sort	Yuki Toyama
title	Dynamic regulation of GDP binding to G proteins revealed by magnetic field-dependent NMR relaxation analyses
title_short	Dynamic regulation of GDP binding to G proteins revealed by magnetic field-dependent NMR relaxation analyses
title_full	Dynamic regulation of GDP binding to G proteins revealed by magnetic field-dependent NMR relaxation analyses
title_fullStr	Dynamic regulation of GDP binding to G proteins revealed by magnetic field-dependent NMR relaxation analyses
title_full_unstemmed	Dynamic regulation of GDP binding to G proteins revealed by magnetic field-dependent NMR relaxation analyses
title_sort	dynamic regulation of gdp binding to g proteins revealed by magnetic field-dependent nmr relaxation analyses
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/985f87fc49594e81ade0f518bf2a63de
work_keys_str_mv	AT yukitoyama dynamicregulationofgdpbindingtogproteinsrevealedbymagneticfielddependentnmrrelaxationanalyses AT hanahokano dynamicregulationofgdpbindingtogproteinsrevealedbymagneticfielddependentnmrrelaxationanalyses AT yokomase dynamicregulationofgdpbindingtogproteinsrevealedbymagneticfielddependentnmrrelaxationanalyses AT marikoyokogawa dynamicregulationofgdpbindingtogproteinsrevealedbymagneticfielddependentnmrrelaxationanalyses AT masanoriosawa dynamicregulationofgdpbindingtogproteinsrevealedbymagneticfielddependentnmrrelaxationanalyses AT ichioshimada dynamicregulationofgdpbindingtogproteinsrevealedbymagneticfielddependentnmrrelaxationanalyses
_version_	1718381627654012928

Dynamic regulation of GDP binding to G proteins revealed by magnetic field-dependent NMR relaxation analyses

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