Balloon-expanding stent and delivery system for transcatheter aortic valve implantation: An animal study

Objective: To evaluate the feasibility and satefy of transcatheter aortic valve implantation in animals by using a new balloon-expanding valved stent. Methods: The balloon-expandable stent is made from cobalt-based alloy material and designed with a tubular, slotted structure. Fresh bovine pericardi...

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Autores principales:	Xiang Chen, Fei-Yu Wang, Guo-Jun Chu, Yu-Feng Zhu, Hong-Wen Tan, Xian-Xian Zhao, Yong-Wen Qin, Jun-Bo Ge
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2015
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/98610726846e41cca0f6a4bca91cd9ba
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spelling	oai:doaj.org-article:98610726846e41cca0f6a4bca91cd9ba2021-12-02T13:26:35ZBalloon-expanding stent and delivery system for transcatheter aortic valve implantation: An animal study2095-882X10.1016/j.cdtm.2015.06.005https://doaj.org/article/98610726846e41cca0f6a4bca91cd9ba2015-06-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2095882X15000365https://doaj.org/toc/2095-882XObjective: To evaluate the feasibility and satefy of transcatheter aortic valve implantation in animals by using a new balloon-expanding valved stent. Methods: The balloon-expandable stent is made from cobalt-based alloy material and designed with a tubular, slotted structure. Fresh bovine pericardium was treated, sutured and fixed on the balloon-expandable stent. Ten healthy sheep (five males and five females), weighing an average of (25.16 ± 1.83) kg, were selected to undergo transcatheter implantation of the valve stents. The function of the valve stent was evaluated by angiography, echocardiography, and histology six months after the procedure. Results: Of the ten experimental sheep, two sheep died during the operation because the higher position of the artificial valve affected the opening of the coronary artery. We successfully implanted the aortic valve stent in other eight sheep; however, one sheep died of heart failure two weeks after the operation due to the lower position of the valve stent. The valve stents were implanted in the desired position in seven sheep. Ascending aortic angiographic and autoptic findings immediately after the operation confirmed the satisfactory location and function of the valved stent. Echocardiography, angiography, and histology at six postoperative months confirmed the satisfactory location and function of the valve stent. Conclusion: We successfully implanted our new valve stent as a replacement of native aortic valve via the transcatheter route with satisfactory outcome. Keywords: Percutaneous, Aortic valve replacement, Balloon-expandable stent, Stent shiftingXiang ChenFei-Yu WangGuo-Jun ChuYu-Feng ZhuHong-Wen TanXian-Xian ZhaoYong-Wen QinJun-Bo GeKeAi Communications Co., Ltd.articleMedicine (General)R5-920ENChronic Diseases and Translational Medicine, Vol 1, Iss 2, Pp 73-80 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Xiang Chen Fei-Yu Wang Guo-Jun Chu Yu-Feng Zhu Hong-Wen Tan Xian-Xian Zhao Yong-Wen Qin Jun-Bo Ge Balloon-expanding stent and delivery system for transcatheter aortic valve implantation: An animal study
description	Objective: To evaluate the feasibility and satefy of transcatheter aortic valve implantation in animals by using a new balloon-expanding valved stent. Methods: The balloon-expandable stent is made from cobalt-based alloy material and designed with a tubular, slotted structure. Fresh bovine pericardium was treated, sutured and fixed on the balloon-expandable stent. Ten healthy sheep (five males and five females), weighing an average of (25.16 ± 1.83) kg, were selected to undergo transcatheter implantation of the valve stents. The function of the valve stent was evaluated by angiography, echocardiography, and histology six months after the procedure. Results: Of the ten experimental sheep, two sheep died during the operation because the higher position of the artificial valve affected the opening of the coronary artery. We successfully implanted the aortic valve stent in other eight sheep; however, one sheep died of heart failure two weeks after the operation due to the lower position of the valve stent. The valve stents were implanted in the desired position in seven sheep. Ascending aortic angiographic and autoptic findings immediately after the operation confirmed the satisfactory location and function of the valved stent. Echocardiography, angiography, and histology at six postoperative months confirmed the satisfactory location and function of the valve stent. Conclusion: We successfully implanted our new valve stent as a replacement of native aortic valve via the transcatheter route with satisfactory outcome. Keywords: Percutaneous, Aortic valve replacement, Balloon-expandable stent, Stent shifting
format	article
author	Xiang Chen Fei-Yu Wang Guo-Jun Chu Yu-Feng Zhu Hong-Wen Tan Xian-Xian Zhao Yong-Wen Qin Jun-Bo Ge
author_facet	Xiang Chen Fei-Yu Wang Guo-Jun Chu Yu-Feng Zhu Hong-Wen Tan Xian-Xian Zhao Yong-Wen Qin Jun-Bo Ge
author_sort	Xiang Chen
title	Balloon-expanding stent and delivery system for transcatheter aortic valve implantation: An animal study
title_short	Balloon-expanding stent and delivery system for transcatheter aortic valve implantation: An animal study
title_full	Balloon-expanding stent and delivery system for transcatheter aortic valve implantation: An animal study
title_fullStr	Balloon-expanding stent and delivery system for transcatheter aortic valve implantation: An animal study
title_full_unstemmed	Balloon-expanding stent and delivery system for transcatheter aortic valve implantation: An animal study
title_sort	balloon-expanding stent and delivery system for transcatheter aortic valve implantation: an animal study
publisher	KeAi Communications Co., Ltd.
publishDate	2015
url	https://doaj.org/article/98610726846e41cca0f6a4bca91cd9ba
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Balloon-expanding stent and delivery system for transcatheter aortic valve implantation: An animal study

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