RXRs control serous macrophage neonatal expansion and identity and contribute to ovarian cancer progression

RXRs control serous macrophage neonatal expansion and identity and contribute to ovarian cancer progression

Macrophages can differentiate to perform homeostatic tissue-specific functions. Here the authors show that RXR signalling is critical for large peritoneal macrophage (LPM) expansion during neonatal life and LPM lipid metabolism and survival during adult homeostasis, and that ovarian cancer growth re...

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Autores principales: María Casanova-Acebes, María Piedad Menéndez-Gutiérrez, Jesús Porcuna, Damiana Álvarez-Errico, Yonit Lavin, Ana García, Soma Kobayashi, Jessica Le Berichel, Vanessa Núñez, Felipe Were, Daniel Jiménez-Carretero, Fátima Sánchez-Cabo, Miriam Merad, Mercedes Ricote
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Science
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Acceso en línea:https://doaj.org/article/9861219ed13d485aaa69a215b09bfe82
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Sumario:Macrophages can differentiate to perform homeostatic tissue-specific functions. Here the authors show that RXR signalling is critical for large peritoneal macrophage (LPM) expansion during neonatal life and LPM lipid metabolism and survival during adult homeostasis, and that ovarian cancer growth relies on RXR-dependent LPMs. 

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