RXRs control serous macrophage neonatal expansion and identity and contribute to ovarian cancer progression

Macrophages can differentiate to perform homeostatic tissue-specific functions. Here the authors show that RXR signalling is critical for large peritoneal macrophage (LPM) expansion during neonatal life and LPM lipid metabolism and survival during adult homeostasis, and that ovarian cancer growth re...

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Autores principales:	María Casanova-Acebes, María Piedad Menéndez-Gutiérrez, Jesús Porcuna, Damiana Álvarez-Errico, Yonit Lavin, Ana García, Soma Kobayashi, Jessica Le Berichel, Vanessa Núñez, Felipe Were, Daniel Jiménez-Carretero, Fátima Sánchez-Cabo, Miriam Merad, Mercedes Ricote
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9861219ed13d485aaa69a215b09bfe82
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spelling	oai:doaj.org-article:9861219ed13d485aaa69a215b09bfe822021-12-02T16:49:14ZRXRs control serous macrophage neonatal expansion and identity and contribute to ovarian cancer progression10.1038/s41467-020-15371-02041-1723https://doaj.org/article/9861219ed13d485aaa69a215b09bfe822020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15371-0https://doaj.org/toc/2041-1723Macrophages can differentiate to perform homeostatic tissue-specific functions. Here the authors show that RXR signalling is critical for large peritoneal macrophage (LPM) expansion during neonatal life and LPM lipid metabolism and survival during adult homeostasis, and that ovarian cancer growth relies on RXR-dependent LPMs. María Casanova-AcebesMaría Piedad Menéndez-GutiérrezJesús PorcunaDamiana Álvarez-ErricoYonit LavinAna GarcíaSoma KobayashiJessica Le BerichelVanessa NúñezFelipe WereDaniel Jiménez-CarreteroFátima Sánchez-CaboMiriam MeradMercedes RicoteNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q María Casanova-Acebes María Piedad Menéndez-Gutiérrez Jesús Porcuna Damiana Álvarez-Errico Yonit Lavin Ana García Soma Kobayashi Jessica Le Berichel Vanessa Núñez Felipe Were Daniel Jiménez-Carretero Fátima Sánchez-Cabo Miriam Merad Mercedes Ricote RXRs control serous macrophage neonatal expansion and identity and contribute to ovarian cancer progression
description	Macrophages can differentiate to perform homeostatic tissue-specific functions. Here the authors show that RXR signalling is critical for large peritoneal macrophage (LPM) expansion during neonatal life and LPM lipid metabolism and survival during adult homeostasis, and that ovarian cancer growth relies on RXR-dependent LPMs.
format	article
author	María Casanova-Acebes María Piedad Menéndez-Gutiérrez Jesús Porcuna Damiana Álvarez-Errico Yonit Lavin Ana García Soma Kobayashi Jessica Le Berichel Vanessa Núñez Felipe Were Daniel Jiménez-Carretero Fátima Sánchez-Cabo Miriam Merad Mercedes Ricote
author_facet	María Casanova-Acebes María Piedad Menéndez-Gutiérrez Jesús Porcuna Damiana Álvarez-Errico Yonit Lavin Ana García Soma Kobayashi Jessica Le Berichel Vanessa Núñez Felipe Were Daniel Jiménez-Carretero Fátima Sánchez-Cabo Miriam Merad Mercedes Ricote
author_sort	María Casanova-Acebes
title	RXRs control serous macrophage neonatal expansion and identity and contribute to ovarian cancer progression
title_short	RXRs control serous macrophage neonatal expansion and identity and contribute to ovarian cancer progression
title_full	RXRs control serous macrophage neonatal expansion and identity and contribute to ovarian cancer progression
title_fullStr	RXRs control serous macrophage neonatal expansion and identity and contribute to ovarian cancer progression
title_full_unstemmed	RXRs control serous macrophage neonatal expansion and identity and contribute to ovarian cancer progression
title_sort	rxrs control serous macrophage neonatal expansion and identity and contribute to ovarian cancer progression
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/9861219ed13d485aaa69a215b09bfe82
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RXRs control serous macrophage neonatal expansion and identity and contribute to ovarian cancer progression

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