Lactate activates HIF-1 in oxidative but not in Warburg-phenotype human tumor cells.

Lactate activates HIF-1 in oxidative but not in Warburg-phenotype human tumor cells.

Cancer can be envisioned as a metabolic disease driven by pressure selection and intercellular cooperativeness. Together with anaerobic glycolysis, the Warburg effect, formally corresponding to uncoupling glycolysis from oxidative phosphorylation, directly participates in cancer aggressiveness, supp...

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Autores principales: Christophe J De Saedeleer, Tamara Copetti, Paolo E Porporato, Julien Verrax, Olivier Feron, Pierre Sonveaux
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
Materias:
Medicine
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Science
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Acceso en línea:https://doaj.org/article/9863463c24784addba273d7388d4e2f9
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