Effects of concurrent and staggered dosing of semi-solid enteral nutrients on pharmacokinetic behavior of antiepileptic drugs after oral administration in rats

<h4>Background</h4> The use of enteral nutrients plays a highly important role in accurate nutrition management, but limited information is currently available on the cautionary points of semi-solid enteral nutrients. <h4>Aim</h4> In this study, we examined whether the pharma...

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Autores principales:	Katsuhito Nagai, Yoshikazu Ryuno, Yoshihito Iwanami, Sachiko Omotani, Shuhei Fukuno, Yasutoshi Hatsuda, Hiroki Konishi, Michiaki Myotoku
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/986472829df2464881bbc5ab064a2a6a
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spelling	oai:doaj.org-article:986472829df2464881bbc5ab064a2a6a2021-11-18T06:34:41ZEffects of concurrent and staggered dosing of semi-solid enteral nutrients on pharmacokinetic behavior of antiepileptic drugs after oral administration in rats1932-6203https://doaj.org/article/986472829df2464881bbc5ab064a2a6a2021-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8577762/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4> The use of enteral nutrients plays a highly important role in accurate nutrition management, but limited information is currently available on the cautionary points of semi-solid enteral nutrients. <h4>Aim</h4> In this study, we examined whether the pharmacokinetic profiles of sodium valproate (SVA), levetiracetam (LEV), and carbamazepine (CBZ) are affected by altering the dosing time of RACOL®-NF Semi Solid for Enteral Use (RASS), a prescribed semi-solid formula. We also investigated whether the pharmacokinetic interaction observed in this study can be avoided by staggered dosing of the chemical drug and semi-solid enteral nutrient. <h4>Methods</h4> The plasma concentration of SVA, LEV and CBZ after oral administration was measured by LC-MS/MS method. <h4>Results</h4> There was no difference in pharmacokinetic characteristics of SVA and LEV when the dosing time of RASS was altered. On the other hand, the plasma concentration of CBZ after oral administration at all sampling points decreased with the extension of the dosing time of RASS, which was consistent with the Cmax and AUC. However, no significant difference was observed in the pharmacokinetic profiles or parameters of CBZ between the short-term and long-term RASS dosing groups by prolonging the administered interval of CBZ and RASS for 2 hr. <h4>Conclusion</h4> We concluded that the pharmacokinetic profiles of CBZ, but not SVA and LEV, after its oral administration are affected by the dosing time of RASS, but staggered administration of CBZ and RASS prevented their interaction.Katsuhito NagaiYoshikazu RyunoYoshihito IwanamiSachiko OmotaniShuhei FukunoYasutoshi HatsudaHiroki KonishiMichiaki MyotokuPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Katsuhito Nagai Yoshikazu Ryuno Yoshihito Iwanami Sachiko Omotani Shuhei Fukuno Yasutoshi Hatsuda Hiroki Konishi Michiaki Myotoku Effects of concurrent and staggered dosing of semi-solid enteral nutrients on pharmacokinetic behavior of antiepileptic drugs after oral administration in rats
description	<h4>Background</h4> The use of enteral nutrients plays a highly important role in accurate nutrition management, but limited information is currently available on the cautionary points of semi-solid enteral nutrients. <h4>Aim</h4> In this study, we examined whether the pharmacokinetic profiles of sodium valproate (SVA), levetiracetam (LEV), and carbamazepine (CBZ) are affected by altering the dosing time of RACOL®-NF Semi Solid for Enteral Use (RASS), a prescribed semi-solid formula. We also investigated whether the pharmacokinetic interaction observed in this study can be avoided by staggered dosing of the chemical drug and semi-solid enteral nutrient. <h4>Methods</h4> The plasma concentration of SVA, LEV and CBZ after oral administration was measured by LC-MS/MS method. <h4>Results</h4> There was no difference in pharmacokinetic characteristics of SVA and LEV when the dosing time of RASS was altered. On the other hand, the plasma concentration of CBZ after oral administration at all sampling points decreased with the extension of the dosing time of RASS, which was consistent with the Cmax and AUC. However, no significant difference was observed in the pharmacokinetic profiles or parameters of CBZ between the short-term and long-term RASS dosing groups by prolonging the administered interval of CBZ and RASS for 2 hr. <h4>Conclusion</h4> We concluded that the pharmacokinetic profiles of CBZ, but not SVA and LEV, after its oral administration are affected by the dosing time of RASS, but staggered administration of CBZ and RASS prevented their interaction.
format	article
author	Katsuhito Nagai Yoshikazu Ryuno Yoshihito Iwanami Sachiko Omotani Shuhei Fukuno Yasutoshi Hatsuda Hiroki Konishi Michiaki Myotoku
author_facet	Katsuhito Nagai Yoshikazu Ryuno Yoshihito Iwanami Sachiko Omotani Shuhei Fukuno Yasutoshi Hatsuda Hiroki Konishi Michiaki Myotoku
author_sort	Katsuhito Nagai
title	Effects of concurrent and staggered dosing of semi-solid enteral nutrients on pharmacokinetic behavior of antiepileptic drugs after oral administration in rats
title_short	Effects of concurrent and staggered dosing of semi-solid enteral nutrients on pharmacokinetic behavior of antiepileptic drugs after oral administration in rats
title_full	Effects of concurrent and staggered dosing of semi-solid enteral nutrients on pharmacokinetic behavior of antiepileptic drugs after oral administration in rats
title_fullStr	Effects of concurrent and staggered dosing of semi-solid enteral nutrients on pharmacokinetic behavior of antiepileptic drugs after oral administration in rats
title_full_unstemmed	Effects of concurrent and staggered dosing of semi-solid enteral nutrients on pharmacokinetic behavior of antiepileptic drugs after oral administration in rats
title_sort	effects of concurrent and staggered dosing of semi-solid enteral nutrients on pharmacokinetic behavior of antiepileptic drugs after oral administration in rats
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/986472829df2464881bbc5ab064a2a6a
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Effects of concurrent and staggered dosing of semi-solid enteral nutrients on pharmacokinetic behavior of antiepileptic drugs after oral administration in rats

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