Effects of Sintering Temperature on Crystallization and Fabrication of Porous Bioactive Glass Scaffolds for Bone Regeneration

Abstract In this work the sintering ability of borosilicate (S53B50), borophosphate (P40B10) and phosphate (Sr) bioactive glasses was investigated. The glass powders were crushed and sintered in air at a heating rate of 10 °C/min for 2 hours at sintering temperatures between 480 °C–600 °C. The aim w...

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Autores principales:	E. P. Erasmus, O. T. Johnson, I. Sigalas, J. Massera
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9865242f7dc043109f495e43d2cf590f
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spelling	oai:doaj.org-article:9865242f7dc043109f495e43d2cf590f2021-12-02T16:06:18ZEffects of Sintering Temperature on Crystallization and Fabrication of Porous Bioactive Glass Scaffolds for Bone Regeneration10.1038/s41598-017-06337-22045-2322https://doaj.org/article/9865242f7dc043109f495e43d2cf590f2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-06337-2https://doaj.org/toc/2045-2322Abstract In this work the sintering ability of borosilicate (S53B50), borophosphate (P40B10) and phosphate (Sr) bioactive glasses was investigated. The glass powders were crushed and sintered in air at a heating rate of 10 °C/min for 2 hours at sintering temperatures between 480 °C–600 °C. The aim was to define the optimum sintering temperature prior to glass crystallization. The density of the samples was found to decrease when the temperature was increased up to 580 °C; probably due to the inhibition of the viscous flow of the particles during sintering thereby reducing the densification of the material. Such low porosity is not suitable in tissue engineering. To process highly porous scaffolds with porosity required for scaffold applicable to tissue engineering, the powders were further mixed with 60 vol.% and 70 vol.% of NH4(HCO3) foaming agent. Meanwhile, the density of the samples sintered with NH4(HCO3) was found to decrease with an increase in NH4(HCO3) content. This indicates an increase in porosity of the samples. The glass compositions reached an open porosity of more than 60% at the addition of 70 vol.% NH4(HCO3). In addition, SEM micrograph revealed large pores with good interconnection between the pores.E. P. ErasmusO. T. JohnsonI. SigalasJ. MasseraNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q E. P. Erasmus O. T. Johnson I. Sigalas J. Massera Effects of Sintering Temperature on Crystallization and Fabrication of Porous Bioactive Glass Scaffolds for Bone Regeneration
description	Abstract In this work the sintering ability of borosilicate (S53B50), borophosphate (P40B10) and phosphate (Sr) bioactive glasses was investigated. The glass powders were crushed and sintered in air at a heating rate of 10 °C/min for 2 hours at sintering temperatures between 480 °C–600 °C. The aim was to define the optimum sintering temperature prior to glass crystallization. The density of the samples was found to decrease when the temperature was increased up to 580 °C; probably due to the inhibition of the viscous flow of the particles during sintering thereby reducing the densification of the material. Such low porosity is not suitable in tissue engineering. To process highly porous scaffolds with porosity required for scaffold applicable to tissue engineering, the powders were further mixed with 60 vol.% and 70 vol.% of NH4(HCO3) foaming agent. Meanwhile, the density of the samples sintered with NH4(HCO3) was found to decrease with an increase in NH4(HCO3) content. This indicates an increase in porosity of the samples. The glass compositions reached an open porosity of more than 60% at the addition of 70 vol.% NH4(HCO3). In addition, SEM micrograph revealed large pores with good interconnection between the pores.
format	article
author	E. P. Erasmus O. T. Johnson I. Sigalas J. Massera
author_facet	E. P. Erasmus O. T. Johnson I. Sigalas J. Massera
author_sort	E. P. Erasmus
title	Effects of Sintering Temperature on Crystallization and Fabrication of Porous Bioactive Glass Scaffolds for Bone Regeneration
title_short	Effects of Sintering Temperature on Crystallization and Fabrication of Porous Bioactive Glass Scaffolds for Bone Regeneration
title_full	Effects of Sintering Temperature on Crystallization and Fabrication of Porous Bioactive Glass Scaffolds for Bone Regeneration
title_fullStr	Effects of Sintering Temperature on Crystallization and Fabrication of Porous Bioactive Glass Scaffolds for Bone Regeneration
title_full_unstemmed	Effects of Sintering Temperature on Crystallization and Fabrication of Porous Bioactive Glass Scaffolds for Bone Regeneration
title_sort	effects of sintering temperature on crystallization and fabrication of porous bioactive glass scaffolds for bone regeneration
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/9865242f7dc043109f495e43d2cf590f
work_keys_str_mv	AT eperasmus effectsofsinteringtemperatureoncrystallizationandfabricationofporousbioactiveglassscaffoldsforboneregeneration AT otjohnson effectsofsinteringtemperatureoncrystallizationandfabricationofporousbioactiveglassscaffoldsforboneregeneration AT isigalas effectsofsinteringtemperatureoncrystallizationandfabricationofporousbioactiveglassscaffoldsforboneregeneration AT jmassera effectsofsinteringtemperatureoncrystallizationandfabricationofporousbioactiveglassscaffoldsforboneregeneration
_version_	1718385039956246528

Effects of Sintering Temperature on Crystallization and Fabrication of Porous Bioactive Glass Scaffolds for Bone Regeneration

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