Large differences in aging phenotype between strains of the short-lived annual fish Nothobranchius furzeri.

<h4>Background</h4>A laboratory inbred strain of the annual fish Nothobranchius furzeri shows exceptionally short life expectancy and accelerated expression of age markers. In this study, we analyze new wild-derived lines of this short-lived species.<h4>Methodology/principal findin...

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Autores principales:	Eva Terzibasi, Dario Riccardo Valenzano, Mauro Benedetti, Paola Roncaglia, Antonino Cattaneo, Luciano Domenici, Alessandro Cellerino
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2008
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9867d7cc146d44ddaf7a7b687567fa5b
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spelling	oai:doaj.org-article:9867d7cc146d44ddaf7a7b687567fa5b2021-11-25T06:18:19ZLarge differences in aging phenotype between strains of the short-lived annual fish Nothobranchius furzeri.1932-620310.1371/journal.pone.0003866https://doaj.org/article/9867d7cc146d44ddaf7a7b687567fa5b2008-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19052641/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>A laboratory inbred strain of the annual fish Nothobranchius furzeri shows exceptionally short life expectancy and accelerated expression of age markers. In this study, we analyze new wild-derived lines of this short-lived species.<h4>Methodology/principal findings</h4>We characterized captive survival and age-related traits in F1 and F2 offspring of wild-caught N. furzeri. Wild-derived N. furzeri lines showed expression of lipofuscin and neurodegeneration at age 21 weeks. Median lifespan in the laboratory varied from to 20 to 23 weeks and maximum lifespan from 25 to 32 weeks. These data demonstrate that rapid age-dependent decline and short lifespan are natural characteristics of this species. The N. furzeri distribution range overlaps with gradients in altitude and aridity. Fish from more arid habitats are expected to experience a shorter survival window in the wild. We tested whether captive lines stemming from semi-arid and sub-humid habitats differ in longevity and expression of age-related traits. We detected a clear difference in age-dependent cognitive decline and a slight difference in lifespan (16% for median, 15% for maximum lifespan) between these lines. Finally, we observed shorter lifespan and accelerated expression of age-related markers in the inbred laboratory strain compared to these wild-derived lines.<h4>Conclusions/significance</h4>Owing to large differences in aging phenotypes in different lines, N. furzeri could represent a model system for studying the genetic control of life-history traits in natural populations.Eva TerzibasiDario Riccardo ValenzanoMauro BenedettiPaola RoncagliaAntonino CattaneoLuciano DomeniciAlessandro CellerinoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 3, Iss 12, p e3866 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Eva Terzibasi Dario Riccardo Valenzano Mauro Benedetti Paola Roncaglia Antonino Cattaneo Luciano Domenici Alessandro Cellerino Large differences in aging phenotype between strains of the short-lived annual fish Nothobranchius furzeri.
description	<h4>Background</h4>A laboratory inbred strain of the annual fish Nothobranchius furzeri shows exceptionally short life expectancy and accelerated expression of age markers. In this study, we analyze new wild-derived lines of this short-lived species.<h4>Methodology/principal findings</h4>We characterized captive survival and age-related traits in F1 and F2 offspring of wild-caught N. furzeri. Wild-derived N. furzeri lines showed expression of lipofuscin and neurodegeneration at age 21 weeks. Median lifespan in the laboratory varied from to 20 to 23 weeks and maximum lifespan from 25 to 32 weeks. These data demonstrate that rapid age-dependent decline and short lifespan are natural characteristics of this species. The N. furzeri distribution range overlaps with gradients in altitude and aridity. Fish from more arid habitats are expected to experience a shorter survival window in the wild. We tested whether captive lines stemming from semi-arid and sub-humid habitats differ in longevity and expression of age-related traits. We detected a clear difference in age-dependent cognitive decline and a slight difference in lifespan (16% for median, 15% for maximum lifespan) between these lines. Finally, we observed shorter lifespan and accelerated expression of age-related markers in the inbred laboratory strain compared to these wild-derived lines.<h4>Conclusions/significance</h4>Owing to large differences in aging phenotypes in different lines, N. furzeri could represent a model system for studying the genetic control of life-history traits in natural populations.
format	article
author	Eva Terzibasi Dario Riccardo Valenzano Mauro Benedetti Paola Roncaglia Antonino Cattaneo Luciano Domenici Alessandro Cellerino
author_facet	Eva Terzibasi Dario Riccardo Valenzano Mauro Benedetti Paola Roncaglia Antonino Cattaneo Luciano Domenici Alessandro Cellerino
author_sort	Eva Terzibasi
title	Large differences in aging phenotype between strains of the short-lived annual fish Nothobranchius furzeri.
title_short	Large differences in aging phenotype between strains of the short-lived annual fish Nothobranchius furzeri.
title_full	Large differences in aging phenotype between strains of the short-lived annual fish Nothobranchius furzeri.
title_fullStr	Large differences in aging phenotype between strains of the short-lived annual fish Nothobranchius furzeri.
title_full_unstemmed	Large differences in aging phenotype between strains of the short-lived annual fish Nothobranchius furzeri.
title_sort	large differences in aging phenotype between strains of the short-lived annual fish nothobranchius furzeri.
publisher	Public Library of Science (PLoS)
publishDate	2008
url	https://doaj.org/article/9867d7cc146d44ddaf7a7b687567fa5b
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Large differences in aging phenotype between strains of the short-lived annual fish Nothobranchius furzeri.

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