Topography of the chimpanzee corpus callosum.

The corpus callosum (CC) is the largest commissural white matter tract in mammalian brains, connecting homotopic and heterotopic regions of the cerebral cortex. Knowledge of the distribution of callosal fibers projecting into specific cortical regions has important implications for understanding the...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Kimberley A Phillips, William D Hopkins
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/986b88137b1e4905b25db32206da6ba7
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:986b88137b1e4905b25db32206da6ba7
record_format	dspace
spelling	oai:doaj.org-article:986b88137b1e4905b25db32206da6ba72021-11-18T07:28:07ZTopography of the chimpanzee corpus callosum.1932-620310.1371/journal.pone.0031941https://doaj.org/article/986b88137b1e4905b25db32206da6ba72012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22355406/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203The corpus callosum (CC) is the largest commissural white matter tract in mammalian brains, connecting homotopic and heterotopic regions of the cerebral cortex. Knowledge of the distribution of callosal fibers projecting into specific cortical regions has important implications for understanding the evolution of lateralized structures and functions of the cerebral cortex. No comparisons of CC topography in humans and great apes have yet been conducted. We investigated the topography of the CC in 21 chimpanzees using high-resolution magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI). Tractography was conducted based on fiber assignment by continuous tracking (FACT) algorithm. We expected chimpanzees to display topographical organization similar to humans, especially concerning projections into the frontal cortical regions. Similar to recent studies in humans, tractography identified five clusters of CC fibers projecting into defined cortical regions: prefrontal; premotor and supplementary motor; motor; sensory; parietal, temporal and occipital. Significant differences in fractional anisotropy (FA) were found in callosal regions, with highest FA values in regions projecting to higher-association areas of posterior cortical (including parietal, temporal and occipital cortices) and prefrontal cortical regions (p<0.001). The lowest FA values were seen in regions projecting into motor and sensory cortical areas. Our results indicate chimpanzees display similar topography of the CC as humans, in terms of distribution of callosal projections and microstructure of fibers as determined by anisotropy measures.Kimberley A PhillipsWilliam D HopkinsPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 2, p e31941 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kimberley A Phillips William D Hopkins Topography of the chimpanzee corpus callosum.
description	The corpus callosum (CC) is the largest commissural white matter tract in mammalian brains, connecting homotopic and heterotopic regions of the cerebral cortex. Knowledge of the distribution of callosal fibers projecting into specific cortical regions has important implications for understanding the evolution of lateralized structures and functions of the cerebral cortex. No comparisons of CC topography in humans and great apes have yet been conducted. We investigated the topography of the CC in 21 chimpanzees using high-resolution magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI). Tractography was conducted based on fiber assignment by continuous tracking (FACT) algorithm. We expected chimpanzees to display topographical organization similar to humans, especially concerning projections into the frontal cortical regions. Similar to recent studies in humans, tractography identified five clusters of CC fibers projecting into defined cortical regions: prefrontal; premotor and supplementary motor; motor; sensory; parietal, temporal and occipital. Significant differences in fractional anisotropy (FA) were found in callosal regions, with highest FA values in regions projecting to higher-association areas of posterior cortical (including parietal, temporal and occipital cortices) and prefrontal cortical regions (p<0.001). The lowest FA values were seen in regions projecting into motor and sensory cortical areas. Our results indicate chimpanzees display similar topography of the CC as humans, in terms of distribution of callosal projections and microstructure of fibers as determined by anisotropy measures.
format	article
author	Kimberley A Phillips William D Hopkins
author_facet	Kimberley A Phillips William D Hopkins
author_sort	Kimberley A Phillips
title	Topography of the chimpanzee corpus callosum.
title_short	Topography of the chimpanzee corpus callosum.
title_full	Topography of the chimpanzee corpus callosum.
title_fullStr	Topography of the chimpanzee corpus callosum.
title_full_unstemmed	Topography of the chimpanzee corpus callosum.
title_sort	topography of the chimpanzee corpus callosum.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/986b88137b1e4905b25db32206da6ba7
work_keys_str_mv	AT kimberleyaphillips topographyofthechimpanzeecorpuscallosum AT williamdhopkins topographyofthechimpanzeecorpuscallosum
_version_	1718423426523201536

Topography of the chimpanzee corpus callosum.

Ejemplares similares