The Aβ(1–38) peptide is a negative regulator of the Aβ(1–42) peptide implicated in Alzheimer disease progression

The Aβ(1–38) peptide is a negative regulator of the Aβ(1–42) peptide implicated in Alzheimer disease progression

Abstract The pool of β-Amyloid (Aβ) length variants detected in preclinical and clinical Alzheimer disease (AD) samples suggests a diversity of roles for Aβ peptides. We examined how a naturally occurring variant, e.g. Aβ(1–38), interacts with the AD-related variant, Aβ(1–42), and the predominant ph...

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Autores principales: Maa O. Quartey, Jennifer N. K. Nyarko, Jason M. Maley, Jocelyn R. Barnes, Maria A. C. Bolanos, Ryan M. Heistad, Kaeli J. Knudsen, Paul R. Pennington, Josef Buttigieg, Carlos E. De Carvalho, Scot C. Leary, Matthew P. Parsons, Darrell D. Mousseau
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/986c73bc802940a9ae4cdf2d043e1a43
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