Septin Assembly and Remodeling at the Cell Division Site During the Cell Cycle

The septin family of proteins can assemble into filaments that further organize into different higher order structures to perform a variety of different functions in different cell types and organisms. In the budding yeast Saccharomyces cerevisiae, the septins localize to the presumptive bud site as...

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Autores principales:	Joseph Marquardt, Xi Chen, Erfei Bi
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	septins septin-associated proteins RhoGEF anillin Elm1 Bud3 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/986d3eb47e6245cd825250ddeb7841a2
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spelling	oai:doaj.org-article:986d3eb47e6245cd825250ddeb7841a22021-12-01T02:19:41ZSeptin Assembly and Remodeling at the Cell Division Site During the Cell Cycle2296-634X10.3389/fcell.2021.793920https://doaj.org/article/986d3eb47e6245cd825250ddeb7841a22021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcell.2021.793920/fullhttps://doaj.org/toc/2296-634XThe septin family of proteins can assemble into filaments that further organize into different higher order structures to perform a variety of different functions in different cell types and organisms. In the budding yeast Saccharomyces cerevisiae, the septins localize to the presumptive bud site as a cortical ring prior to bud emergence, expand into an hourglass at the bud neck (cell division site) during bud growth, and finally “split” into a double ring sandwiching the cell division machinery during cytokinesis. While much work has been done to understand the functions and molecular makeups of these structures, the mechanisms underlying the transitions from one structure to another have largely remained elusive. Recent studies involving advanced imaging and in vitro reconstitution have begun to reveal the vast complexity involved in the regulation of these structural transitions, which defines the focus of discussion in this mini-review.Joseph MarquardtXi ChenErfei BiFrontiers Media S.A.articleseptinsseptin-associated proteinsRhoGEFanillinElm1Bud3Biology (General)QH301-705.5ENFrontiers in Cell and Developmental Biology, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	septins septin-associated proteins RhoGEF anillin Elm1 Bud3 Biology (General) QH301-705.5
spellingShingle	septins septin-associated proteins RhoGEF anillin Elm1 Bud3 Biology (General) QH301-705.5 Joseph Marquardt Xi Chen Erfei Bi Septin Assembly and Remodeling at the Cell Division Site During the Cell Cycle
description	The septin family of proteins can assemble into filaments that further organize into different higher order structures to perform a variety of different functions in different cell types and organisms. In the budding yeast Saccharomyces cerevisiae, the septins localize to the presumptive bud site as a cortical ring prior to bud emergence, expand into an hourglass at the bud neck (cell division site) during bud growth, and finally “split” into a double ring sandwiching the cell division machinery during cytokinesis. While much work has been done to understand the functions and molecular makeups of these structures, the mechanisms underlying the transitions from one structure to another have largely remained elusive. Recent studies involving advanced imaging and in vitro reconstitution have begun to reveal the vast complexity involved in the regulation of these structural transitions, which defines the focus of discussion in this mini-review.
format	article
author	Joseph Marquardt Xi Chen Erfei Bi
author_facet	Joseph Marquardt Xi Chen Erfei Bi
author_sort	Joseph Marquardt
title	Septin Assembly and Remodeling at the Cell Division Site During the Cell Cycle
title_short	Septin Assembly and Remodeling at the Cell Division Site During the Cell Cycle
title_full	Septin Assembly and Remodeling at the Cell Division Site During the Cell Cycle
title_fullStr	Septin Assembly and Remodeling at the Cell Division Site During the Cell Cycle
title_full_unstemmed	Septin Assembly and Remodeling at the Cell Division Site During the Cell Cycle
title_sort	septin assembly and remodeling at the cell division site during the cell cycle
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/986d3eb47e6245cd825250ddeb7841a2
work_keys_str_mv	AT josephmarquardt septinassemblyandremodelingatthecelldivisionsiteduringthecellcycle AT xichen septinassemblyandremodelingatthecelldivisionsiteduringthecellcycle AT erfeibi septinassemblyandremodelingatthecelldivisionsiteduringthecellcycle
_version_	1718405918003036160

Septin Assembly and Remodeling at the Cell Division Site During the Cell Cycle

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