Vulnerabilities in coronavirus glycan shields despite extensive glycosylation

Glycosylation plays a key role in shielding of immunogenic epitopes on viral spike (S) proteins. Here Watanabe et al. report that glycans of coronavirus SARS and MERS S proteins are heterogeneously distributed and do not form an efficacious high-density global shield which would ensure efficient imm...

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Autores principales:	Yasunori Watanabe, Zachary T. Berndsen, Jayna Raghwani, Gemma E. Seabright, Joel D. Allen, Oliver G. Pybus, Jason S. McLellan, Ian A. Wilson, Thomas A. Bowden, Andrew B. Ward, Max Crispin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9870ee47e6b94013917875773aa8dfd3
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spelling	oai:doaj.org-article:9870ee47e6b94013917875773aa8dfd32021-12-02T16:53:08ZVulnerabilities in coronavirus glycan shields despite extensive glycosylation10.1038/s41467-020-16567-02041-1723https://doaj.org/article/9870ee47e6b94013917875773aa8dfd32020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16567-0https://doaj.org/toc/2041-1723Glycosylation plays a key role in shielding of immunogenic epitopes on viral spike (S) proteins. Here Watanabe et al. report that glycans of coronavirus SARS and MERS S proteins are heterogeneously distributed and do not form an efficacious high-density global shield which would ensure efficient immune evasion.Yasunori WatanabeZachary T. BerndsenJayna RaghwaniGemma E. SeabrightJoel D. AllenOliver G. PybusJason S. McLellanIan A. WilsonThomas A. BowdenAndrew B. WardMax CrispinNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yasunori Watanabe Zachary T. Berndsen Jayna Raghwani Gemma E. Seabright Joel D. Allen Oliver G. Pybus Jason S. McLellan Ian A. Wilson Thomas A. Bowden Andrew B. Ward Max Crispin Vulnerabilities in coronavirus glycan shields despite extensive glycosylation
description	Glycosylation plays a key role in shielding of immunogenic epitopes on viral spike (S) proteins. Here Watanabe et al. report that glycans of coronavirus SARS and MERS S proteins are heterogeneously distributed and do not form an efficacious high-density global shield which would ensure efficient immune evasion.
format	article
author	Yasunori Watanabe Zachary T. Berndsen Jayna Raghwani Gemma E. Seabright Joel D. Allen Oliver G. Pybus Jason S. McLellan Ian A. Wilson Thomas A. Bowden Andrew B. Ward Max Crispin
author_facet	Yasunori Watanabe Zachary T. Berndsen Jayna Raghwani Gemma E. Seabright Joel D. Allen Oliver G. Pybus Jason S. McLellan Ian A. Wilson Thomas A. Bowden Andrew B. Ward Max Crispin
author_sort	Yasunori Watanabe
title	Vulnerabilities in coronavirus glycan shields despite extensive glycosylation
title_short	Vulnerabilities in coronavirus glycan shields despite extensive glycosylation
title_full	Vulnerabilities in coronavirus glycan shields despite extensive glycosylation
title_fullStr	Vulnerabilities in coronavirus glycan shields despite extensive glycosylation
title_full_unstemmed	Vulnerabilities in coronavirus glycan shields despite extensive glycosylation
title_sort	vulnerabilities in coronavirus glycan shields despite extensive glycosylation
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/9870ee47e6b94013917875773aa8dfd3
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Vulnerabilities in coronavirus glycan shields despite extensive glycosylation

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