IDENTIFICATION OF ANTIGEN-SPECIFIC HORMONE-RESISTANT BLOOD LYMPHOCYTES TO PREDICT EFFICIENCY OF GLUCOCORTICOID THERAPY IN BRONCHIAL ASTHMA

Abstract. At present time, the main therapeutic goal in bronchial asthma treatment is to achieve complete control of the disease. Appropriate medical evaluation involves a complex system of clinical criteria and functional parameters obtained by instrumental and laboratory techniques. ...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	A. A. Kalashnikova, N. V. Bychkova, N. I. Davydova, M. V. Zhdanova, M. K. Evloeva, G. A. Novik
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	bronchial asthma inhalatory glucocorticosteroids resistance lymphocyte proliferation Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/9878308306664bbc894bdefe79907e6a
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:9878308306664bbc894bdefe79907e6a
record_format	dspace
spelling	oai:doaj.org-article:9878308306664bbc894bdefe79907e6a2021-11-18T08:03:42ZIDENTIFICATION OF ANTIGEN-SPECIFIC HORMONE-RESISTANT BLOOD LYMPHOCYTES TO PREDICT EFFICIENCY OF GLUCOCORTICOID THERAPY IN BRONCHIAL ASTHMA1563-06252313-741X10.15789/1563-0625-2011-2-3-155-166https://doaj.org/article/9878308306664bbc894bdefe79907e6a2014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/477https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. At present time, the main therapeutic goal in bronchial asthma treatment is to achieve complete control of the disease. Appropriate medical evaluation involves a complex system of clinical criteria and functional parameters obtained by instrumental and laboratory techniques. Wide application of inhalatory glucocorticosteroids (IGCS) in childhood bronchial asthma treatment, requirements for a long-term therapy, and common IGCS dose-escalation regimens determine an importance of searching novel objective criteria to predict efficiency of the therapy preformed. In present work, we propose a method aimed to identify glucocorticosteroid-resistant lymphocytes in peripheral blood of the patients with bronchial asthma undergoing IGCS therapy. The results of this study have shown that clinical efficiency of such treatment of bronchial asthma patients, independently on the IGCS dosage, may be evaluated by the degree of steroid-induced suppression of in vitro lymphocyte proliferation caused by a domestic dust antigen. The data obtained may be used in clinical settings to predict efficiency of IGCS therapy and adjust treatment regimens in bronchial asthma patients. (Med. Immunol., 2011, vol. 13, N 2-3, pp 157-166)A. A. KalashnikovaN. V. BychkovaN. I. DavydovaM. V. ZhdanovaM. K. EvloevaG. A. NovikSPb RAACIarticlebronchial asthmainhalatory glucocorticosteroidsresistancelymphocyte proliferationImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 13, Iss 2-3, Pp 155-166 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	bronchial asthma inhalatory glucocorticosteroids resistance lymphocyte proliferation Immunologic diseases. Allergy RC581-607
spellingShingle	bronchial asthma inhalatory glucocorticosteroids resistance lymphocyte proliferation Immunologic diseases. Allergy RC581-607 A. A. Kalashnikova N. V. Bychkova N. I. Davydova M. V. Zhdanova M. K. Evloeva G. A. Novik IDENTIFICATION OF ANTIGEN-SPECIFIC HORMONE-RESISTANT BLOOD LYMPHOCYTES TO PREDICT EFFICIENCY OF GLUCOCORTICOID THERAPY IN BRONCHIAL ASTHMA
description	Abstract. At present time, the main therapeutic goal in bronchial asthma treatment is to achieve complete control of the disease. Appropriate medical evaluation involves a complex system of clinical criteria and functional parameters obtained by instrumental and laboratory techniques. Wide application of inhalatory glucocorticosteroids (IGCS) in childhood bronchial asthma treatment, requirements for a long-term therapy, and common IGCS dose-escalation regimens determine an importance of searching novel objective criteria to predict efficiency of the therapy preformed. In present work, we propose a method aimed to identify glucocorticosteroid-resistant lymphocytes in peripheral blood of the patients with bronchial asthma undergoing IGCS therapy. The results of this study have shown that clinical efficiency of such treatment of bronchial asthma patients, independently on the IGCS dosage, may be evaluated by the degree of steroid-induced suppression of in vitro lymphocyte proliferation caused by a domestic dust antigen. The data obtained may be used in clinical settings to predict efficiency of IGCS therapy and adjust treatment regimens in bronchial asthma patients. (Med. Immunol., 2011, vol. 13, N 2-3, pp 157-166)
format	article
author	A. A. Kalashnikova N. V. Bychkova N. I. Davydova M. V. Zhdanova M. K. Evloeva G. A. Novik
author_facet	A. A. Kalashnikova N. V. Bychkova N. I. Davydova M. V. Zhdanova M. K. Evloeva G. A. Novik
author_sort	A. A. Kalashnikova
title	IDENTIFICATION OF ANTIGEN-SPECIFIC HORMONE-RESISTANT BLOOD LYMPHOCYTES TO PREDICT EFFICIENCY OF GLUCOCORTICOID THERAPY IN BRONCHIAL ASTHMA
title_short	IDENTIFICATION OF ANTIGEN-SPECIFIC HORMONE-RESISTANT BLOOD LYMPHOCYTES TO PREDICT EFFICIENCY OF GLUCOCORTICOID THERAPY IN BRONCHIAL ASTHMA
title_full	IDENTIFICATION OF ANTIGEN-SPECIFIC HORMONE-RESISTANT BLOOD LYMPHOCYTES TO PREDICT EFFICIENCY OF GLUCOCORTICOID THERAPY IN BRONCHIAL ASTHMA
title_fullStr	IDENTIFICATION OF ANTIGEN-SPECIFIC HORMONE-RESISTANT BLOOD LYMPHOCYTES TO PREDICT EFFICIENCY OF GLUCOCORTICOID THERAPY IN BRONCHIAL ASTHMA
title_full_unstemmed	IDENTIFICATION OF ANTIGEN-SPECIFIC HORMONE-RESISTANT BLOOD LYMPHOCYTES TO PREDICT EFFICIENCY OF GLUCOCORTICOID THERAPY IN BRONCHIAL ASTHMA
title_sort	identification of antigen-specific hormone-resistant blood lymphocytes to predict efficiency of glucocorticoid therapy in bronchial asthma
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/9878308306664bbc894bdefe79907e6a
work_keys_str_mv	AT aakalashnikova identificationofantigenspecifichormoneresistantbloodlymphocytestopredictefficiencyofglucocorticoidtherapyinbronchialasthma AT nvbychkova identificationofantigenspecifichormoneresistantbloodlymphocytestopredictefficiencyofglucocorticoidtherapyinbronchialasthma AT nidavydova identificationofantigenspecifichormoneresistantbloodlymphocytestopredictefficiencyofglucocorticoidtherapyinbronchialasthma AT mvzhdanova identificationofantigenspecifichormoneresistantbloodlymphocytestopredictefficiencyofglucocorticoidtherapyinbronchialasthma AT mkevloeva identificationofantigenspecifichormoneresistantbloodlymphocytestopredictefficiencyofglucocorticoidtherapyinbronchialasthma AT ganovik identificationofantigenspecifichormoneresistantbloodlymphocytestopredictefficiencyofglucocorticoidtherapyinbronchialasthma
_version_	1718422494741790720

IDENTIFICATION OF ANTIGEN-SPECIFIC HORMONE-RESISTANT BLOOD LYMPHOCYTES TO PREDICT EFFICIENCY OF GLUCOCORTICOID THERAPY IN BRONCHIAL ASTHMA

Ejemplares similares