Mice Fed an Obesogenic Western Diet, Administered Antibiotics, and Subjected to a Sterile Surgical Procedure Develop Lethal Septicemia with Multidrug-Resistant Pathobionts

Mice Fed an Obesogenic Western Diet, Administered Antibiotics, and Subjected to a Sterile Surgical Procedure Develop Lethal Septicemia with Multidrug-Resistant Pathobionts

ABSTRACT Despite antibiotics and sterile technique, postoperative infections remain a real and present danger to patients. Recent estimates suggest that 50% of the pathogens associated with postoperative infections have become resistant to the standard antibiotics used for prophylaxis. Risk factors...

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Main Authors: Sanjiv K. Hyoju, Alexander Zaborin, Robert Keskey, Anukriti Sharma, Wyatt Arnold, Fons van den Berg, Sangman M. Kim, Neil Gottel, Cindy Bethel, Angella Charnot-Katsikas, Peng Jianxin, Carleen Adriaansens, Emily Papazian, Jack A. Gilbert, Olga Zaborina, John C. Alverdy
Format: article
Language:EN
Published: American Society for Microbiology 2019
Subjects:
Western diet
gut microbiome
gut-derived sepsis
pathobionts
surgery
Microbiology
QR1-502
Online Access:https://doaj.org/article/987ac7b19e284871ac3edc524ace133f
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https://doaj.org/article/987ac7b19e284871ac3edc524ace133f

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