Urinary exosome microRNA signatures as a noninvasive prognostic biomarker for prostate cancer

Abstract Predicting the risk of metastasis before starting prostate cancer (PCa) treatment can minimize the overtreatment of indolent cases and help choosing appropriate treatment. The levels of circulating microRNAs (miRNAs) from body fluids can be used as noninvasive prognostic biomarkers. In this...

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Autores principales:	Sun Shin, Yong Hyun Park, Seung-Hyun Jung, Sun-Hee Jang, Mee Young Kim, Ji Youl Lee, Yeun–Jun Chung
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Genetics QH426-470
Acceso en línea:	https://doaj.org/article/987b95c76a454f4fb99b1319305b8277
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spelling	oai:doaj.org-article:987b95c76a454f4fb99b1319305b82772021-12-02T15:03:08ZUrinary exosome microRNA signatures as a noninvasive prognostic biomarker for prostate cancer10.1038/s41525-021-00212-w2056-7944https://doaj.org/article/987b95c76a454f4fb99b1319305b82772021-06-01T00:00:00Zhttps://doi.org/10.1038/s41525-021-00212-whttps://doaj.org/toc/2056-7944Abstract Predicting the risk of metastasis before starting prostate cancer (PCa) treatment can minimize the overtreatment of indolent cases and help choosing appropriate treatment. The levels of circulating microRNAs (miRNAs) from body fluids can be used as noninvasive prognostic biomarkers. In this study, urinary exosomal miRNA expression profiles of 149 PCas were determined and the miRNAs associated with metastasis were identified: miR-21, miR-16, miR-142-3p, miR-451, and miR-636. When evaluating clinical factors together, miR-21, miR-451, miR-636, and preoperative prostate-specific antigen (PSA) level remained significant in the multivariate analysis. Based on them, we developed a “Prostate Cancer Metastasis Risk Scoring (PCa-MRS)” model. The PCa-MRS showed superior stratification power (AUC = 0.925) to preoperative PSA or clinical Gleason score. Patients with high scores showed significantly poorer biochemical recurrence-free survival than those with low scores (P = 6.53 × 10−10). Our results showed the potential of urinary exosomal miRNAs as noninvasive markers for predicting metastasis and prognosis in PCa patients.Sun ShinYong Hyun ParkSeung-Hyun JungSun-Hee JangMee Young KimJi Youl LeeYeun–Jun ChungNature PortfolioarticleMedicineRGeneticsQH426-470ENnpj Genomic Medicine, Vol 6, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Genetics QH426-470
spellingShingle	Medicine R Genetics QH426-470 Sun Shin Yong Hyun Park Seung-Hyun Jung Sun-Hee Jang Mee Young Kim Ji Youl Lee Yeun–Jun Chung Urinary exosome microRNA signatures as a noninvasive prognostic biomarker for prostate cancer
description	Abstract Predicting the risk of metastasis before starting prostate cancer (PCa) treatment can minimize the overtreatment of indolent cases and help choosing appropriate treatment. The levels of circulating microRNAs (miRNAs) from body fluids can be used as noninvasive prognostic biomarkers. In this study, urinary exosomal miRNA expression profiles of 149 PCas were determined and the miRNAs associated with metastasis were identified: miR-21, miR-16, miR-142-3p, miR-451, and miR-636. When evaluating clinical factors together, miR-21, miR-451, miR-636, and preoperative prostate-specific antigen (PSA) level remained significant in the multivariate analysis. Based on them, we developed a “Prostate Cancer Metastasis Risk Scoring (PCa-MRS)” model. The PCa-MRS showed superior stratification power (AUC = 0.925) to preoperative PSA or clinical Gleason score. Patients with high scores showed significantly poorer biochemical recurrence-free survival than those with low scores (P = 6.53 × 10−10). Our results showed the potential of urinary exosomal miRNAs as noninvasive markers for predicting metastasis and prognosis in PCa patients.
format	article
author	Sun Shin Yong Hyun Park Seung-Hyun Jung Sun-Hee Jang Mee Young Kim Ji Youl Lee Yeun–Jun Chung
author_facet	Sun Shin Yong Hyun Park Seung-Hyun Jung Sun-Hee Jang Mee Young Kim Ji Youl Lee Yeun–Jun Chung
author_sort	Sun Shin
title	Urinary exosome microRNA signatures as a noninvasive prognostic biomarker for prostate cancer
title_short	Urinary exosome microRNA signatures as a noninvasive prognostic biomarker for prostate cancer
title_full	Urinary exosome microRNA signatures as a noninvasive prognostic biomarker for prostate cancer
title_fullStr	Urinary exosome microRNA signatures as a noninvasive prognostic biomarker for prostate cancer
title_full_unstemmed	Urinary exosome microRNA signatures as a noninvasive prognostic biomarker for prostate cancer
title_sort	urinary exosome microrna signatures as a noninvasive prognostic biomarker for prostate cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/987b95c76a454f4fb99b1319305b8277
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Urinary exosome microRNA signatures as a noninvasive prognostic biomarker for prostate cancer

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