Double-stranded RNA induces chicken T-cell lymphoma apoptosis by TRIF and NF-κB

Abstract Toll-like receptor-3 (TLR3), a member of the pathogen recognition receptor family, has been reported to activate immune response and to exhibit pro-apoptotic activity against some tumor cells. However it is unclear whether TLR3 has same function against chicken lymphoma. In this paper we in...

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Autores principales:	Haitao Zou, Ruixue Su, Jing Ruan, Hongxia Shao, Kun Qian, Jianqiang Ye, Yongxiu Yao, Venugopal Nair, Aijian Qin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/987e860553594082ba37fa92c8f06093
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spelling	oai:doaj.org-article:987e860553594082ba37fa92c8f060932021-12-02T16:06:32ZDouble-stranded RNA induces chicken T-cell lymphoma apoptosis by TRIF and NF-κB10.1038/s41598-017-07919-w2045-2322https://doaj.org/article/987e860553594082ba37fa92c8f060932017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-07919-whttps://doaj.org/toc/2045-2322Abstract Toll-like receptor-3 (TLR3), a member of the pathogen recognition receptor family, has been reported to activate immune response and to exhibit pro-apoptotic activity against some tumor cells. However it is unclear whether TLR3 has same function against chicken lymphoma. In this paper we investigated the effect of TLR3 activation on a Marek’s disease lymphoma-derived chicken cell line, MDCC-MSB1. The TLR3 agonist poly (I:C) activated TLR3 pathway and inhibited tumor cells proliferation through caspase-dependent apoptosis. Using pharmacological approaches, we found that an interferon-independent mechanism involving Toll-IL-1-receptor domain-containing adapter-inducing IFN-α (TRIF) and nuclear factor κB (NF-κB) causes the apoptosis of MDCC-MSB1 cells. This is the first report about the function of TLR3 in chicken T-cell lymphoma, especially in signal pathway. The mechanisms underlying TLR3-mediated apoptosis may contribute to the development of new drug to treat lymphomas and oncovirus infections.Haitao ZouRuixue SuJing RuanHongxia ShaoKun QianJianqiang YeYongxiu YaoVenugopal NairAijian QinNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Haitao Zou Ruixue Su Jing Ruan Hongxia Shao Kun Qian Jianqiang Ye Yongxiu Yao Venugopal Nair Aijian Qin Double-stranded RNA induces chicken T-cell lymphoma apoptosis by TRIF and NF-κB
description	Abstract Toll-like receptor-3 (TLR3), a member of the pathogen recognition receptor family, has been reported to activate immune response and to exhibit pro-apoptotic activity against some tumor cells. However it is unclear whether TLR3 has same function against chicken lymphoma. In this paper we investigated the effect of TLR3 activation on a Marek’s disease lymphoma-derived chicken cell line, MDCC-MSB1. The TLR3 agonist poly (I:C) activated TLR3 pathway and inhibited tumor cells proliferation through caspase-dependent apoptosis. Using pharmacological approaches, we found that an interferon-independent mechanism involving Toll-IL-1-receptor domain-containing adapter-inducing IFN-α (TRIF) and nuclear factor κB (NF-κB) causes the apoptosis of MDCC-MSB1 cells. This is the first report about the function of TLR3 in chicken T-cell lymphoma, especially in signal pathway. The mechanisms underlying TLR3-mediated apoptosis may contribute to the development of new drug to treat lymphomas and oncovirus infections.
format	article
author	Haitao Zou Ruixue Su Jing Ruan Hongxia Shao Kun Qian Jianqiang Ye Yongxiu Yao Venugopal Nair Aijian Qin
author_facet	Haitao Zou Ruixue Su Jing Ruan Hongxia Shao Kun Qian Jianqiang Ye Yongxiu Yao Venugopal Nair Aijian Qin
author_sort	Haitao Zou
title	Double-stranded RNA induces chicken T-cell lymphoma apoptosis by TRIF and NF-κB
title_short	Double-stranded RNA induces chicken T-cell lymphoma apoptosis by TRIF and NF-κB
title_full	Double-stranded RNA induces chicken T-cell lymphoma apoptosis by TRIF and NF-κB
title_fullStr	Double-stranded RNA induces chicken T-cell lymphoma apoptosis by TRIF and NF-κB
title_full_unstemmed	Double-stranded RNA induces chicken T-cell lymphoma apoptosis by TRIF and NF-κB
title_sort	double-stranded rna induces chicken t-cell lymphoma apoptosis by trif and nf-κb
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/987e860553594082ba37fa92c8f06093
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Double-stranded RNA induces chicken T-cell lymphoma apoptosis by TRIF and NF-κB

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