Heart rate variability as an independent predictor for 8-year mortality among chronic hemodialysis patients

Abstract The repeated measurements of heart rate variability (HRV) is more relevant than a single HRV measurement in predicting patient prognosis but is less addressed previously. This prospective study aimed to investigate the association between repeated measurements of HRV and long-term mortality...

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Autores principales:	Yu-Ming Chang, Ya-Ting Huang, I-Ling Chen, Chuan-Lan Yang, Show-Chin Leu, Hung-Li Su, Jsun-Liang Kao, Shih-Ching Tsai, Rong-Na Jhen, Chih-Chung Shiao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9882100b2f5547faaec274edc5412250
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spelling	oai:doaj.org-article:9882100b2f5547faaec274edc54122502021-12-02T15:23:40ZHeart rate variability as an independent predictor for 8-year mortality among chronic hemodialysis patients10.1038/s41598-020-57792-32045-2322https://doaj.org/article/9882100b2f5547faaec274edc54122502020-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-57792-3https://doaj.org/toc/2045-2322Abstract The repeated measurements of heart rate variability (HRV) is more relevant than a single HRV measurement in predicting patient prognosis but is less addressed previously. This prospective study aimed to investigate the association between repeated measurements of HRV and long-term mortality in chronic hemodialysis patients. The 164 patients (65.0 ± 13.1 years; woman, 57.3%) were enrolled from June 1, 2010, to August 31, 2010, and received four HRV measurements (before and during the index hemodialysis session) after the enrollment. The baseline characteristic and clinical variables, including mortality, were documented. The joint modeling method and Cox regression were used for statistical analyses. After an 8-year follow-up, 79 patients expired, and 85 patients survived. We found that higher normalized high-frequency (nHF) (hazard ratio [HR] 1.033) as well as lower very-low-frequency (HR 0.990), Variance (HR 0.991), normalized low-frequency (HR 0.999, P = 0.006), and low-frequency/high-frequency ratio (HR 0.796) were independent predictors for cardiovascular mortality. Whereas the independent predictors for infection-associated mortality included higher nHF (HR 1.033) as well as higher age (HR 19.29) and lower serum albumin (HR 0.01, P = 0.001). (all P < 0.001 unless otherwise stated) In conclusion, HRV measurement predicts long-term mortality among hemodialysis patients.Yu-Ming ChangYa-Ting HuangI-Ling ChenChuan-Lan YangShow-Chin LeuHung-Li SuJsun-Liang KaoShih-Ching TsaiRong-Na JhenChih-Chung ShiaoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yu-Ming Chang Ya-Ting Huang I-Ling Chen Chuan-Lan Yang Show-Chin Leu Hung-Li Su Jsun-Liang Kao Shih-Ching Tsai Rong-Na Jhen Chih-Chung Shiao Heart rate variability as an independent predictor for 8-year mortality among chronic hemodialysis patients
description	Abstract The repeated measurements of heart rate variability (HRV) is more relevant than a single HRV measurement in predicting patient prognosis but is less addressed previously. This prospective study aimed to investigate the association between repeated measurements of HRV and long-term mortality in chronic hemodialysis patients. The 164 patients (65.0 ± 13.1 years; woman, 57.3%) were enrolled from June 1, 2010, to August 31, 2010, and received four HRV measurements (before and during the index hemodialysis session) after the enrollment. The baseline characteristic and clinical variables, including mortality, were documented. The joint modeling method and Cox regression were used for statistical analyses. After an 8-year follow-up, 79 patients expired, and 85 patients survived. We found that higher normalized high-frequency (nHF) (hazard ratio [HR] 1.033) as well as lower very-low-frequency (HR 0.990), Variance (HR 0.991), normalized low-frequency (HR 0.999, P = 0.006), and low-frequency/high-frequency ratio (HR 0.796) were independent predictors for cardiovascular mortality. Whereas the independent predictors for infection-associated mortality included higher nHF (HR 1.033) as well as higher age (HR 19.29) and lower serum albumin (HR 0.01, P = 0.001). (all P < 0.001 unless otherwise stated) In conclusion, HRV measurement predicts long-term mortality among hemodialysis patients.
format	article
author	Yu-Ming Chang Ya-Ting Huang I-Ling Chen Chuan-Lan Yang Show-Chin Leu Hung-Li Su Jsun-Liang Kao Shih-Ching Tsai Rong-Na Jhen Chih-Chung Shiao
author_facet	Yu-Ming Chang Ya-Ting Huang I-Ling Chen Chuan-Lan Yang Show-Chin Leu Hung-Li Su Jsun-Liang Kao Shih-Ching Tsai Rong-Na Jhen Chih-Chung Shiao
author_sort	Yu-Ming Chang
title	Heart rate variability as an independent predictor for 8-year mortality among chronic hemodialysis patients
title_short	Heart rate variability as an independent predictor for 8-year mortality among chronic hemodialysis patients
title_full	Heart rate variability as an independent predictor for 8-year mortality among chronic hemodialysis patients
title_fullStr	Heart rate variability as an independent predictor for 8-year mortality among chronic hemodialysis patients
title_full_unstemmed	Heart rate variability as an independent predictor for 8-year mortality among chronic hemodialysis patients
title_sort	heart rate variability as an independent predictor for 8-year mortality among chronic hemodialysis patients
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/9882100b2f5547faaec274edc5412250
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Heart rate variability as an independent predictor for 8-year mortality among chronic hemodialysis patients

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