Dynamics of TNF-α and IFN-γ in adult patients with measles depending on the development of complications

The aim is to define the dynamics of TNF-α and IFN-γ serum levels in adult patients with measles depending on the development of complications. Materials and methods. An examination of 175 adult patients with measles revealed a range of complications and dynamics of serum TNF-α and IFN-γ dependin...

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Autores principales:	S. O. Bilokobyla, O. V. Riabokon, Yu. Yu. Riabokon, N. V. Onishchenko
Formato:	article
Lenguaje:	EN RU UK
Publicado:	Zaporozhye State Medical University 2021
Materias:	measles adults complications cytokines Medicine R
Acceso en línea:	https://doaj.org/article/988253a522f14a28a713fc85e7970d97
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spelling	oai:doaj.org-article:988253a522f14a28a713fc85e7970d972021-11-08T08:38:56ZDynamics of TNF-α and IFN-γ in adult patients with measles depending on the development of complications10.14739/2310-1210.2021.6.2375732306-41452310-1210https://doaj.org/article/988253a522f14a28a713fc85e7970d972021-11-01T00:00:00Zhttp://zmj.zsmu.edu.ua/article/view/237573/241665https://doaj.org/toc/2306-4145https://doaj.org/toc/2310-1210The aim is to define the dynamics of TNF-α and IFN-γ serum levels in adult patients with measles depending on the development of complications. Materials and methods. An examination of 175 adult patients with measles revealed a range of complications and dynamics of serum TNF-α and IFN-γ depending on the development of complications. The serum contents of TNF-α (Invitrogen, Austria) and IFN-γ (Invitrogen, Austria) in patients and 30 healthy individuals were determined by enzyme-linked immunosorbent assay on the basis of the Training Medical Laboratory Center of Zaporizhzhia State MedicalUniversity. Results. It was shown that the vast majority of hospitalized adult patients with measles developed complications (70.6 %) and these latter were predominantly respiratory (61.7 %) and gastrointestinal (44.0 %). In the period of measles rash, on day 4.8 ± 0.2 in the presence of complications, the serum TNF-α content was 11 times higher than that in healthy individuals (P < 0.05) and in patients with uncomplicated measles (P < 0.05), and did not differ from healthy individuals (P > 0.05) in the absence of complications. The development of measles complications in adult patients was associated with higher serum levels of TNF-α both at hospitalization (P = 0.003) and after 10 days of the disease (P = 0.005). The serum content of IFN-γ in adult measles patients with rash at hospitalization on day 4.8 ± 0.2 exceeded that in healthy individuals both in the presence of complications (P < 0.05) and in uncomplicated measles (P < 0.05). The serum content of IFN-γ was 19.3 times (P < 0.05) higher in patients with complicated measles than that in patients without complications. High serum levels of IFN-γ were associated with the development of complications during acute period of measles (P = 0.0001). Conclusions. Complications occurred in most hospitalized adult patients with measles (70.6 %), that was accompanied by more pronounced immunological changes. The development of measles complications in adult patients was associated with higher serum levels of TNF-α both at hospital admission on day 4.8 ± 0.2 (gamma 0.77; P = 0.003) and in the dynamics after 10 days of the disease (gamma 0.56; P = 0.005). Elevated serum levels of IFN-γ were associated with the development of complications during the acute period of measles (gamma ratio 0.46; P = 0.0001).S. O. BilokobylaO. V. RiabokonYu. Yu. RiabokonN. V. OnishchenkoZaporozhye State Medical UniversityarticlemeaslesadultscomplicationscytokinesMedicineRENRUUKZaporožskij Medicinskij Žurnal, Vol 23, Iss 6, Pp 834-838 (2021)
institution	DOAJ
collection	DOAJ
language	EN RU UK
topic	measles adults complications cytokines Medicine R
spellingShingle	measles adults complications cytokines Medicine R S. O. Bilokobyla O. V. Riabokon Yu. Yu. Riabokon N. V. Onishchenko Dynamics of TNF-α and IFN-γ in adult patients with measles depending on the development of complications
description	The aim is to define the dynamics of TNF-α and IFN-γ serum levels in adult patients with measles depending on the development of complications. Materials and methods. An examination of 175 adult patients with measles revealed a range of complications and dynamics of serum TNF-α and IFN-γ depending on the development of complications. The serum contents of TNF-α (Invitrogen, Austria) and IFN-γ (Invitrogen, Austria) in patients and 30 healthy individuals were determined by enzyme-linked immunosorbent assay on the basis of the Training Medical Laboratory Center of Zaporizhzhia State MedicalUniversity. Results. It was shown that the vast majority of hospitalized adult patients with measles developed complications (70.6 %) and these latter were predominantly respiratory (61.7 %) and gastrointestinal (44.0 %). In the period of measles rash, on day 4.8 ± 0.2 in the presence of complications, the serum TNF-α content was 11 times higher than that in healthy individuals (P < 0.05) and in patients with uncomplicated measles (P < 0.05), and did not differ from healthy individuals (P > 0.05) in the absence of complications. The development of measles complications in adult patients was associated with higher serum levels of TNF-α both at hospitalization (P = 0.003) and after 10 days of the disease (P = 0.005). The serum content of IFN-γ in adult measles patients with rash at hospitalization on day 4.8 ± 0.2 exceeded that in healthy individuals both in the presence of complications (P < 0.05) and in uncomplicated measles (P < 0.05). The serum content of IFN-γ was 19.3 times (P < 0.05) higher in patients with complicated measles than that in patients without complications. High serum levels of IFN-γ were associated with the development of complications during acute period of measles (P = 0.0001). Conclusions. Complications occurred in most hospitalized adult patients with measles (70.6 %), that was accompanied by more pronounced immunological changes. The development of measles complications in adult patients was associated with higher serum levels of TNF-α both at hospital admission on day 4.8 ± 0.2 (gamma 0.77; P = 0.003) and in the dynamics after 10 days of the disease (gamma 0.56; P = 0.005). Elevated serum levels of IFN-γ were associated with the development of complications during the acute period of measles (gamma ratio 0.46; P = 0.0001).
format	article
author	S. O. Bilokobyla O. V. Riabokon Yu. Yu. Riabokon N. V. Onishchenko
author_facet	S. O. Bilokobyla O. V. Riabokon Yu. Yu. Riabokon N. V. Onishchenko
author_sort	S. O. Bilokobyla
title	Dynamics of TNF-α and IFN-γ in adult patients with measles depending on the development of complications
title_short	Dynamics of TNF-α and IFN-γ in adult patients with measles depending on the development of complications
title_full	Dynamics of TNF-α and IFN-γ in adult patients with measles depending on the development of complications
title_fullStr	Dynamics of TNF-α and IFN-γ in adult patients with measles depending on the development of complications
title_full_unstemmed	Dynamics of TNF-α and IFN-γ in adult patients with measles depending on the development of complications
title_sort	dynamics of tnf-α and ifn-γ in adult patients with measles depending on the development of complications
publisher	Zaporozhye State Medical University
publishDate	2021
url	https://doaj.org/article/988253a522f14a28a713fc85e7970d97
work_keys_str_mv	AT sobilokobyla dynamicsoftnfaandifnginadultpatientswithmeaslesdependingonthedevelopmentofcomplications AT ovriabokon dynamicsoftnfaandifnginadultpatientswithmeaslesdependingonthedevelopmentofcomplications AT yuyuriabokon dynamicsoftnfaandifnginadultpatientswithmeaslesdependingonthedevelopmentofcomplications AT nvonishchenko dynamicsoftnfaandifnginadultpatientswithmeaslesdependingonthedevelopmentofcomplications
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Dynamics of TNF-α and IFN-γ in adult patients with measles depending on the development of complications

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