Evaluating the relationship between spermatogenic silencing of the X chromosome and evolution of the Y chromosome in chimpanzee and human.

Chimpanzees and humans are genetically very similar, with the striking exception of their Y chromosomes, which have diverged tremendously. The male-specific region (MSY), representing the greater part of the Y chromosome, is inherited from father to son in a clonal fashion, with natural selection ac...

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Autores principales:	Eskeatnaf Mulugeta Achame, Willy M Baarends, Joost Gribnau, J Anton Grootegoed
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2010
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9883c58b2e724ea4a53cabaa2177f23f
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spelling	oai:doaj.org-article:9883c58b2e724ea4a53cabaa2177f23f2021-11-18T07:01:43ZEvaluating the relationship between spermatogenic silencing of the X chromosome and evolution of the Y chromosome in chimpanzee and human.1932-620310.1371/journal.pone.0015598https://doaj.org/article/9883c58b2e724ea4a53cabaa2177f23f2010-12-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21179482/?tool=EBIhttps://doaj.org/toc/1932-6203Chimpanzees and humans are genetically very similar, with the striking exception of their Y chromosomes, which have diverged tremendously. The male-specific region (MSY), representing the greater part of the Y chromosome, is inherited from father to son in a clonal fashion, with natural selection acting on the MSY as a unit. Positive selection might involve the performance of the MSY in spermatogenesis. Chimpanzees have a highly polygamous mating behavior, so that sperm competition is thought to provide a strong selective force acting on the Y chromosome in the chimpanzee lineage. In consequence of evolution of the heterologous sex chromosomes in mammals, meiotic sex chromosome inactivation (MSCI) results in a transcriptionally silenced XY body in male meiotic prophase, and subsequently also in postmeiotic repression of the sex chromosomes in haploid spermatids. This has evolved to a situation where MSCI has become a prerequisite for spermatogenesis. Here, by analysis of microarray testicular expression data representing a small number of male chimpanzees and men, we obtained information indicating that meiotic and postmeiotic X chromosome silencing might be more effective in chimpanzee than in human spermatogenesis. From this, we suggest that the remarkable reorganization of the chimpanzee Y chromosome, compared to the human Y chromosome, might have an impact on its meiotic interactions with the X chromosome and thereby on X chromosome silencing in spermatogenesis. Further studies will be required to address comparative functional aspects of MSCI in chimpanzee, human, and other placental mammals.Eskeatnaf Mulugeta AchameWilly M BaarendsJoost GribnauJ Anton GrootegoedPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 5, Iss 12, p e15598 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Eskeatnaf Mulugeta Achame Willy M Baarends Joost Gribnau J Anton Grootegoed Evaluating the relationship between spermatogenic silencing of the X chromosome and evolution of the Y chromosome in chimpanzee and human.
description	Chimpanzees and humans are genetically very similar, with the striking exception of their Y chromosomes, which have diverged tremendously. The male-specific region (MSY), representing the greater part of the Y chromosome, is inherited from father to son in a clonal fashion, with natural selection acting on the MSY as a unit. Positive selection might involve the performance of the MSY in spermatogenesis. Chimpanzees have a highly polygamous mating behavior, so that sperm competition is thought to provide a strong selective force acting on the Y chromosome in the chimpanzee lineage. In consequence of evolution of the heterologous sex chromosomes in mammals, meiotic sex chromosome inactivation (MSCI) results in a transcriptionally silenced XY body in male meiotic prophase, and subsequently also in postmeiotic repression of the sex chromosomes in haploid spermatids. This has evolved to a situation where MSCI has become a prerequisite for spermatogenesis. Here, by analysis of microarray testicular expression data representing a small number of male chimpanzees and men, we obtained information indicating that meiotic and postmeiotic X chromosome silencing might be more effective in chimpanzee than in human spermatogenesis. From this, we suggest that the remarkable reorganization of the chimpanzee Y chromosome, compared to the human Y chromosome, might have an impact on its meiotic interactions with the X chromosome and thereby on X chromosome silencing in spermatogenesis. Further studies will be required to address comparative functional aspects of MSCI in chimpanzee, human, and other placental mammals.
format	article
author	Eskeatnaf Mulugeta Achame Willy M Baarends Joost Gribnau J Anton Grootegoed
author_facet	Eskeatnaf Mulugeta Achame Willy M Baarends Joost Gribnau J Anton Grootegoed
author_sort	Eskeatnaf Mulugeta Achame
title	Evaluating the relationship between spermatogenic silencing of the X chromosome and evolution of the Y chromosome in chimpanzee and human.
title_short	Evaluating the relationship between spermatogenic silencing of the X chromosome and evolution of the Y chromosome in chimpanzee and human.
title_full	Evaluating the relationship between spermatogenic silencing of the X chromosome and evolution of the Y chromosome in chimpanzee and human.
title_fullStr	Evaluating the relationship between spermatogenic silencing of the X chromosome and evolution of the Y chromosome in chimpanzee and human.
title_full_unstemmed	Evaluating the relationship between spermatogenic silencing of the X chromosome and evolution of the Y chromosome in chimpanzee and human.
title_sort	evaluating the relationship between spermatogenic silencing of the x chromosome and evolution of the y chromosome in chimpanzee and human.
publisher	Public Library of Science (PLoS)
publishDate	2010
url	https://doaj.org/article/9883c58b2e724ea4a53cabaa2177f23f
work_keys_str_mv	AT eskeatnafmulugetaachame evaluatingtherelationshipbetweenspermatogenicsilencingofthexchromosomeandevolutionoftheychromosomeinchimpanzeeandhuman AT willymbaarends evaluatingtherelationshipbetweenspermatogenicsilencingofthexchromosomeandevolutionoftheychromosomeinchimpanzeeandhuman AT joostgribnau evaluatingtherelationshipbetweenspermatogenicsilencingofthexchromosomeandevolutionoftheychromosomeinchimpanzeeandhuman AT jantongrootegoed evaluatingtherelationshipbetweenspermatogenicsilencingofthexchromosomeandevolutionoftheychromosomeinchimpanzeeandhuman
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Evaluating the relationship between spermatogenic silencing of the X chromosome and evolution of the Y chromosome in chimpanzee and human.

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