STING-dependent sensing of self-DNA drives silica-induced lung inflammation
Silica particles induce intereukin-1 (IL-1) response to contribute to lung inflammation, but the underlying mechanism is unclear. Here the authors show that silica induces cell death and release of mitochondria and genomic DNA, which are sensed by STING with or without involving cGAS, respectively,...
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Nature Portfolio
2018
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oai:doaj.org-article:9888d37e2d5a425d97df7c19aed7823f2021-12-02T14:39:46ZSTING-dependent sensing of self-DNA drives silica-induced lung inflammation10.1038/s41467-018-07425-12041-1723https://doaj.org/article/9888d37e2d5a425d97df7c19aed7823f2018-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07425-1https://doaj.org/toc/2041-1723Silica particles induce intereukin-1 (IL-1) response to contribute to lung inflammation, but the underlying mechanism is unclear. Here the authors show that silica induces cell death and release of mitochondria and genomic DNA, which are sensed by STING with or without involving cGAS, respectively, for IL-1 induction and lung inflammation.Sulayman BenmerzougStéphanie RoseBadreddine BounabDavid GossetLaure DuneauPauline ChenuetLucile MolletMarc Le BertChristopher LambersSilvana GeleffMichael RothLouis FauconnierDelphine SeddaClarisse CarvalhoOlivier PercheDavid LaurenceauBernhard RyffelLionel ApetohAhmet KiziltuncHakan UsluFadime Sultan AlbezMetin AkgunDieudonnée TogbeValerie F. J. QuesniauxNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-19 (2018) |
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Science Q |
| spellingShingle |
Science Q Sulayman Benmerzoug Stéphanie Rose Badreddine Bounab David Gosset Laure Duneau Pauline Chenuet Lucile Mollet Marc Le Bert Christopher Lambers Silvana Geleff Michael Roth Louis Fauconnier Delphine Sedda Clarisse Carvalho Olivier Perche David Laurenceau Bernhard Ryffel Lionel Apetoh Ahmet Kiziltunc Hakan Uslu Fadime Sultan Albez Metin Akgun Dieudonnée Togbe Valerie F. J. Quesniaux STING-dependent sensing of self-DNA drives silica-induced lung inflammation |
| description |
Silica particles induce intereukin-1 (IL-1) response to contribute to lung inflammation, but the underlying mechanism is unclear. Here the authors show that silica induces cell death and release of mitochondria and genomic DNA, which are sensed by STING with or without involving cGAS, respectively, for IL-1 induction and lung inflammation. |
| format |
article |
| author |
Sulayman Benmerzoug Stéphanie Rose Badreddine Bounab David Gosset Laure Duneau Pauline Chenuet Lucile Mollet Marc Le Bert Christopher Lambers Silvana Geleff Michael Roth Louis Fauconnier Delphine Sedda Clarisse Carvalho Olivier Perche David Laurenceau Bernhard Ryffel Lionel Apetoh Ahmet Kiziltunc Hakan Uslu Fadime Sultan Albez Metin Akgun Dieudonnée Togbe Valerie F. J. Quesniaux |
| author_facet |
Sulayman Benmerzoug Stéphanie Rose Badreddine Bounab David Gosset Laure Duneau Pauline Chenuet Lucile Mollet Marc Le Bert Christopher Lambers Silvana Geleff Michael Roth Louis Fauconnier Delphine Sedda Clarisse Carvalho Olivier Perche David Laurenceau Bernhard Ryffel Lionel Apetoh Ahmet Kiziltunc Hakan Uslu Fadime Sultan Albez Metin Akgun Dieudonnée Togbe Valerie F. J. Quesniaux |
| author_sort |
Sulayman Benmerzoug |
| title |
STING-dependent sensing of self-DNA drives silica-induced lung inflammation |
| title_short |
STING-dependent sensing of self-DNA drives silica-induced lung inflammation |
| title_full |
STING-dependent sensing of self-DNA drives silica-induced lung inflammation |
| title_fullStr |
STING-dependent sensing of self-DNA drives silica-induced lung inflammation |
| title_full_unstemmed |
STING-dependent sensing of self-DNA drives silica-induced lung inflammation |
| title_sort |
sting-dependent sensing of self-dna drives silica-induced lung inflammation |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/9888d37e2d5a425d97df7c19aed7823f |
| work_keys_str_mv |
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| _version_ |
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