STING-dependent sensing of self-DNA drives silica-induced lung inflammation

STING-dependent sensing of self-DNA drives silica-induced lung inflammation

Silica particles induce intereukin-1 (IL-1) response to contribute to lung inflammation, but the underlying mechanism is unclear. Here the authors show that silica induces cell death and release of mitochondria and genomic DNA, which are sensed by STING with or without involving cGAS, respectively,...

Full description

Saved in:
Bibliographic Details
Main Authors: Sulayman Benmerzoug, Stéphanie Rose, Badreddine Bounab, David Gosset, Laure Duneau, Pauline Chenuet, Lucile Mollet, Marc Le Bert, Christopher Lambers, Silvana Geleff, Michael Roth, Louis Fauconnier, Delphine Sedda, Clarisse Carvalho, Olivier Perche, David Laurenceau, Bernhard Ryffel, Lionel Apetoh, Ahmet Kiziltunc, Hakan Uslu, Fadime Sultan Albez, Metin Akgun, Dieudonnée Togbe, Valerie F. J. Quesniaux
Format: article
Language:EN
Published: Nature Portfolio 2018
Subjects:
Science
Q
Online Access:https://doaj.org/article/9888d37e2d5a425d97df7c19aed7823f
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doaj.org/article/9888d37e2d5a425d97df7c19aed7823f

Similar Items