The effects of golimumab treatment on systolic and diastolic left ventricular function in ankylosing spondylitis

SC Heslinga,1,2 TC Konings,3 IE van der Horst-Bruinsma,1,2 O Kamp,3 VP van Halm,3,4 HACM de Bruin-Bon,4 MJ Peters,5 MT Nurmohamed1,2 1Department of Rheumatology, Amsterdam Rheumatology and Immunology Center, Reade, Amsterdam, The Netherlands; 2Department of Rheumatology, Amsterdam Rheumatology and I...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Heslinga SC, Konings TC, van der Horst-Bruinsma IE, Kamp O, van Halm VP, de Bruin-Bon HACM, Peters MJ, Nurmohamed MT
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Ankylosing Spondylitis Cardiovascular disease anti-TNF Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/988fb7197f174491abd1036633527c76
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:988fb7197f174491abd1036633527c76
record_format	dspace
spelling	oai:doaj.org-article:988fb7197f174491abd1036633527c762021-12-02T07:05:54ZThe effects of golimumab treatment on systolic and diastolic left ventricular function in ankylosing spondylitis1177-5491https://doaj.org/article/988fb7197f174491abd1036633527c762018-11-01T00:00:00Zhttps://www.dovepress.com/the-effects-of-golimumab-treatment-on-systolic-and-diastolic-left-vent-peer-reviewed-article-BTThttps://doaj.org/toc/1177-5491SC Heslinga,1,2 TC Konings,3 IE van der Horst-Bruinsma,1,2 O Kamp,3 VP van Halm,3,4 HACM de Bruin-Bon,4 MJ Peters,5 MT Nurmohamed1,2 1Department of Rheumatology, Amsterdam Rheumatology and Immunology Center, Reade, Amsterdam, The Netherlands; 2Department of Rheumatology, Amsterdam Rheumatology and Immunology Center, VU University Medical Center, Amsterdam, The Netherlands; 3Department of Cardiology, VU University Medical Center, Amsterdam, The Netherlands; 4Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands; 5Department of Internal Medicine, VU University Medical Center, Amsterdam, The Netherlands Background: Diastolic left ventricular (LV) dysfunction appears more prevalent in ankylosing spondylitis (AS). The effects of tumor necrosis factor alpha (TNF-α) blocking therapy, a strong and effective anti-inflammatory drug, on diastolic LV function in AS are unknown. The objective of the study was to find the effects of 1-year treatment with golimumab 50 mg subcutaneously once per month on systolic and diastolic LV dysfunction in AS patients.Methods: Forty consecutive AS patients were treated with TNF-α blocking therapy for 1 year. Transthoracic echocardiography was performed in all patients at baseline and after 1 year of treatment.Results: Diastolic LV function improved after treatment in four out of six (67%) AS patients who completed follow-up (P=0.125), and did not develop or worsen in any of the other patients. Treatment with TNF-α blocking therapy had no effect on systolic LV function.Conclusion: These findings give support to the hypothesis that diastolic LV dysfunction improves during treatment with TNF-α blocking therapy. Keywords: ankylosing spondylitis, cardiovascular disease, anti-TNFHeslinga SCKonings TCvan der Horst-Bruinsma IEKamp Ovan Halm VPde Bruin-Bon HACMPeters MJNurmohamed MTDove Medical PressarticleAnkylosing SpondylitisCardiovascular diseaseanti-TNFMedicine (General)R5-920ENBiologics: Targets & Therapy, Vol Volume 12, Pp 143-149 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ankylosing Spondylitis Cardiovascular disease anti-TNF Medicine (General) R5-920
spellingShingle	Ankylosing Spondylitis Cardiovascular disease anti-TNF Medicine (General) R5-920 Heslinga SC Konings TC van der Horst-Bruinsma IE Kamp O van Halm VP de Bruin-Bon HACM Peters MJ Nurmohamed MT The effects of golimumab treatment on systolic and diastolic left ventricular function in ankylosing spondylitis
description	SC Heslinga,1,2 TC Konings,3 IE van der Horst-Bruinsma,1,2 O Kamp,3 VP van Halm,3,4 HACM de Bruin-Bon,4 MJ Peters,5 MT Nurmohamed1,2 1Department of Rheumatology, Amsterdam Rheumatology and Immunology Center, Reade, Amsterdam, The Netherlands; 2Department of Rheumatology, Amsterdam Rheumatology and Immunology Center, VU University Medical Center, Amsterdam, The Netherlands; 3Department of Cardiology, VU University Medical Center, Amsterdam, The Netherlands; 4Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands; 5Department of Internal Medicine, VU University Medical Center, Amsterdam, The Netherlands Background: Diastolic left ventricular (LV) dysfunction appears more prevalent in ankylosing spondylitis (AS). The effects of tumor necrosis factor alpha (TNF-α) blocking therapy, a strong and effective anti-inflammatory drug, on diastolic LV function in AS are unknown. The objective of the study was to find the effects of 1-year treatment with golimumab 50 mg subcutaneously once per month on systolic and diastolic LV dysfunction in AS patients.Methods: Forty consecutive AS patients were treated with TNF-α blocking therapy for 1 year. Transthoracic echocardiography was performed in all patients at baseline and after 1 year of treatment.Results: Diastolic LV function improved after treatment in four out of six (67%) AS patients who completed follow-up (P=0.125), and did not develop or worsen in any of the other patients. Treatment with TNF-α blocking therapy had no effect on systolic LV function.Conclusion: These findings give support to the hypothesis that diastolic LV dysfunction improves during treatment with TNF-α blocking therapy. Keywords: ankylosing spondylitis, cardiovascular disease, anti-TNF
format	article
author	Heslinga SC Konings TC van der Horst-Bruinsma IE Kamp O van Halm VP de Bruin-Bon HACM Peters MJ Nurmohamed MT
author_facet	Heslinga SC Konings TC van der Horst-Bruinsma IE Kamp O van Halm VP de Bruin-Bon HACM Peters MJ Nurmohamed MT
author_sort	Heslinga SC
title	The effects of golimumab treatment on systolic and diastolic left ventricular function in ankylosing spondylitis
title_short	The effects of golimumab treatment on systolic and diastolic left ventricular function in ankylosing spondylitis
title_full	The effects of golimumab treatment on systolic and diastolic left ventricular function in ankylosing spondylitis
title_fullStr	The effects of golimumab treatment on systolic and diastolic left ventricular function in ankylosing spondylitis
title_full_unstemmed	The effects of golimumab treatment on systolic and diastolic left ventricular function in ankylosing spondylitis
title_sort	effects of golimumab treatment on systolic and diastolic left ventricular function in ankylosing spondylitis
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/988fb7197f174491abd1036633527c76
work_keys_str_mv	AT heslingasc theeffectsofgolimumabtreatmentonsystolicanddiastolicleftventricularfunctioninankylosingspondylitis AT koningstc theeffectsofgolimumabtreatmentonsystolicanddiastolicleftventricularfunctioninankylosingspondylitis AT vanderhorstbruinsmaie theeffectsofgolimumabtreatmentonsystolicanddiastolicleftventricularfunctioninankylosingspondylitis AT kampo theeffectsofgolimumabtreatmentonsystolicanddiastolicleftventricularfunctioninankylosingspondylitis AT vanhalmvp theeffectsofgolimumabtreatmentonsystolicanddiastolicleftventricularfunctioninankylosingspondylitis AT debruinbonhacm theeffectsofgolimumabtreatmentonsystolicanddiastolicleftventricularfunctioninankylosingspondylitis AT petersmj theeffectsofgolimumabtreatmentonsystolicanddiastolicleftventricularfunctioninankylosingspondylitis AT nurmohamedmt theeffectsofgolimumabtreatmentonsystolicanddiastolicleftventricularfunctioninankylosingspondylitis AT heslingasc effectsofgolimumabtreatmentonsystolicanddiastolicleftventricularfunctioninankylosingspondylitis AT koningstc effectsofgolimumabtreatmentonsystolicanddiastolicleftventricularfunctioninankylosingspondylitis AT vanderhorstbruinsmaie effectsofgolimumabtreatmentonsystolicanddiastolicleftventricularfunctioninankylosingspondylitis AT kampo effectsofgolimumabtreatmentonsystolicanddiastolicleftventricularfunctioninankylosingspondylitis AT vanhalmvp effectsofgolimumabtreatmentonsystolicanddiastolicleftventricularfunctioninankylosingspondylitis AT debruinbonhacm effectsofgolimumabtreatmentonsystolicanddiastolicleftventricularfunctioninankylosingspondylitis AT petersmj effectsofgolimumabtreatmentonsystolicanddiastolicleftventricularfunctioninankylosingspondylitis AT nurmohamedmt effectsofgolimumabtreatmentonsystolicanddiastolicleftventricularfunctioninankylosingspondylitis
_version_	1718399590772768768

The effects of golimumab treatment on systolic and diastolic left ventricular function in ankylosing spondylitis

Ejemplares similares