Changes in brain arousal (EEG-vigilance) after therapeutic sleep deprivation in depressive patients and healthy controls

Abstract Depressed patients frequently exhibit a hyperstable brain arousal regulation. According to the arousal regulation model of affective disorders, the antidepressant effect of therapeutic sleep deprivation could be achieved by counter-acting this dysregulation. We investigated the impact of pa...

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Autores principales:	Christian Sander, Jonathan M. Schmidt, Roland Mergl, Frank M. Schmidt, Ulrich Hegerl
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Brain Arousal Depressed Patients Vigilance Stages Partial Sleep Deprivation (PSD) Sleepiness Ratings Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9890def5c43346b8a84a731563fcea42
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spelling	oai:doaj.org-article:9890def5c43346b8a84a731563fcea422021-12-02T15:08:26ZChanges in brain arousal (EEG-vigilance) after therapeutic sleep deprivation in depressive patients and healthy controls10.1038/s41598-018-33228-x2045-2322https://doaj.org/article/9890def5c43346b8a84a731563fcea422018-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-33228-xhttps://doaj.org/toc/2045-2322Abstract Depressed patients frequently exhibit a hyperstable brain arousal regulation. According to the arousal regulation model of affective disorders, the antidepressant effect of therapeutic sleep deprivation could be achieved by counter-acting this dysregulation. We investigated the impact of partial sleep deprivation (PSD) on EEG-vigilance (an indicator of brain arousal regulation) in depressed patients (n = 27) and healthy controls (n = 16). PSD was hypothesized to cause a more prominent destabilisation of brain arousal regulation in depressed patients (reflected by increased occurrence of lower EEG-vigilance stages). Furthermore, it was studied whether responders (n = 17) exhibit a more stable baseline brain arousal regulation and would show a more prominent arousal destabilisation after PSD than non-responders (n = 10). Before PSD, patients showed a more stable EEG-vigilance with less declines to lower vigilance stages compared to controls. Contrary to the hypothesis, a greater destabilisation of brain arousal after PSD was seen in controls. Within the patient sample, responders generally showed a less stable EEG-vigilance, especially after PSD when we found significant differences compared to non-responders. EEG-vigilance in non-responders showed only little change from baseline to after PSD. In summary, PSD had a destabilizing impact on brain arousal regulation in healthy controls whereas depressed patients reacted heterogeneously depending on the outcome of treatment.Christian SanderJonathan M. SchmidtRoland MerglFrank M. SchmidtUlrich HegerlNature PortfolioarticleBrain ArousalDepressed PatientsVigilance StagesPartial Sleep Deprivation (PSD)Sleepiness RatingsMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Brain Arousal Depressed Patients Vigilance Stages Partial Sleep Deprivation (PSD) Sleepiness Ratings Medicine R Science Q
spellingShingle	Brain Arousal Depressed Patients Vigilance Stages Partial Sleep Deprivation (PSD) Sleepiness Ratings Medicine R Science Q Christian Sander Jonathan M. Schmidt Roland Mergl Frank M. Schmidt Ulrich Hegerl Changes in brain arousal (EEG-vigilance) after therapeutic sleep deprivation in depressive patients and healthy controls
description	Abstract Depressed patients frequently exhibit a hyperstable brain arousal regulation. According to the arousal regulation model of affective disorders, the antidepressant effect of therapeutic sleep deprivation could be achieved by counter-acting this dysregulation. We investigated the impact of partial sleep deprivation (PSD) on EEG-vigilance (an indicator of brain arousal regulation) in depressed patients (n = 27) and healthy controls (n = 16). PSD was hypothesized to cause a more prominent destabilisation of brain arousal regulation in depressed patients (reflected by increased occurrence of lower EEG-vigilance stages). Furthermore, it was studied whether responders (n = 17) exhibit a more stable baseline brain arousal regulation and would show a more prominent arousal destabilisation after PSD than non-responders (n = 10). Before PSD, patients showed a more stable EEG-vigilance with less declines to lower vigilance stages compared to controls. Contrary to the hypothesis, a greater destabilisation of brain arousal after PSD was seen in controls. Within the patient sample, responders generally showed a less stable EEG-vigilance, especially after PSD when we found significant differences compared to non-responders. EEG-vigilance in non-responders showed only little change from baseline to after PSD. In summary, PSD had a destabilizing impact on brain arousal regulation in healthy controls whereas depressed patients reacted heterogeneously depending on the outcome of treatment.
format	article
author	Christian Sander Jonathan M. Schmidt Roland Mergl Frank M. Schmidt Ulrich Hegerl
author_facet	Christian Sander Jonathan M. Schmidt Roland Mergl Frank M. Schmidt Ulrich Hegerl
author_sort	Christian Sander
title	Changes in brain arousal (EEG-vigilance) after therapeutic sleep deprivation in depressive patients and healthy controls
title_short	Changes in brain arousal (EEG-vigilance) after therapeutic sleep deprivation in depressive patients and healthy controls
title_full	Changes in brain arousal (EEG-vigilance) after therapeutic sleep deprivation in depressive patients and healthy controls
title_fullStr	Changes in brain arousal (EEG-vigilance) after therapeutic sleep deprivation in depressive patients and healthy controls
title_full_unstemmed	Changes in brain arousal (EEG-vigilance) after therapeutic sleep deprivation in depressive patients and healthy controls
title_sort	changes in brain arousal (eeg-vigilance) after therapeutic sleep deprivation in depressive patients and healthy controls
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/9890def5c43346b8a84a731563fcea42
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Changes in brain arousal (EEG-vigilance) after therapeutic sleep deprivation in depressive patients and healthy controls

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