Targeting local lymphatics to ameliorate heterotopic ossification via FGFR3-BMPR1a pathway

Different types of mesenchymal progenitors participate in ectopic bone formation. Here, the authors show Col2+ lineage cells adopt a lymphatic endothelium cell fate, which regulates local inflammatory microenvironment after trauma, thus influencing heterotopic ossification (HO) development via a FGF...

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Autores principales:	Dali Zhang, Junlan Huang, Xianding Sun, Hangang Chen, Shuo Huang, Jing Yang, Xiaolan Du, Qiaoyan Tan, Fengtao Luo, Ruobin Zhang, Siru Zhou, Wanling Jiang, Zhenhong Ni, Zuqiang Wang, Min Jin, Meng Xu, Fangfang Li, Liang Chen, Mi Liu, Nan Su, Xiaoqing Luo, Liangjun Yin, Ying Zhu, Jerry Q. Feng, Di Chen, Huabing Qi, Lin Chen, Yangli Xie
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/98970981f1554eb68ed709ba30420a0f
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spelling	oai:doaj.org-article:98970981f1554eb68ed709ba30420a0f2021-12-02T16:17:59ZTargeting local lymphatics to ameliorate heterotopic ossification via FGFR3-BMPR1a pathway10.1038/s41467-021-24643-22041-1723https://doaj.org/article/98970981f1554eb68ed709ba30420a0f2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24643-2https://doaj.org/toc/2041-1723Different types of mesenchymal progenitors participate in ectopic bone formation. Here, the authors show Col2+ lineage cells adopt a lymphatic endothelium cell fate, which regulates local inflammatory microenvironment after trauma, thus influencing heterotopic ossification (HO) development via a FGFR3-BMPR1a pathway.Dali ZhangJunlan HuangXianding SunHangang ChenShuo HuangJing YangXiaolan DuQiaoyan TanFengtao LuoRuobin ZhangSiru ZhouWanling JiangZhenhong NiZuqiang WangMin JinMeng XuFangfang LiLiang ChenMi LiuNan SuXiaoqing LuoLiangjun YinYing ZhuJerry Q. FengDi ChenHuabing QiLin ChenYangli XieNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Dali Zhang Junlan Huang Xianding Sun Hangang Chen Shuo Huang Jing Yang Xiaolan Du Qiaoyan Tan Fengtao Luo Ruobin Zhang Siru Zhou Wanling Jiang Zhenhong Ni Zuqiang Wang Min Jin Meng Xu Fangfang Li Liang Chen Mi Liu Nan Su Xiaoqing Luo Liangjun Yin Ying Zhu Jerry Q. Feng Di Chen Huabing Qi Lin Chen Yangli Xie Targeting local lymphatics to ameliorate heterotopic ossification via FGFR3-BMPR1a pathway
description	Different types of mesenchymal progenitors participate in ectopic bone formation. Here, the authors show Col2+ lineage cells adopt a lymphatic endothelium cell fate, which regulates local inflammatory microenvironment after trauma, thus influencing heterotopic ossification (HO) development via a FGFR3-BMPR1a pathway.
format	article
author	Dali Zhang Junlan Huang Xianding Sun Hangang Chen Shuo Huang Jing Yang Xiaolan Du Qiaoyan Tan Fengtao Luo Ruobin Zhang Siru Zhou Wanling Jiang Zhenhong Ni Zuqiang Wang Min Jin Meng Xu Fangfang Li Liang Chen Mi Liu Nan Su Xiaoqing Luo Liangjun Yin Ying Zhu Jerry Q. Feng Di Chen Huabing Qi Lin Chen Yangli Xie
author_facet	Dali Zhang Junlan Huang Xianding Sun Hangang Chen Shuo Huang Jing Yang Xiaolan Du Qiaoyan Tan Fengtao Luo Ruobin Zhang Siru Zhou Wanling Jiang Zhenhong Ni Zuqiang Wang Min Jin Meng Xu Fangfang Li Liang Chen Mi Liu Nan Su Xiaoqing Luo Liangjun Yin Ying Zhu Jerry Q. Feng Di Chen Huabing Qi Lin Chen Yangli Xie
author_sort	Dali Zhang
title	Targeting local lymphatics to ameliorate heterotopic ossification via FGFR3-BMPR1a pathway
title_short	Targeting local lymphatics to ameliorate heterotopic ossification via FGFR3-BMPR1a pathway
title_full	Targeting local lymphatics to ameliorate heterotopic ossification via FGFR3-BMPR1a pathway
title_fullStr	Targeting local lymphatics to ameliorate heterotopic ossification via FGFR3-BMPR1a pathway
title_full_unstemmed	Targeting local lymphatics to ameliorate heterotopic ossification via FGFR3-BMPR1a pathway
title_sort	targeting local lymphatics to ameliorate heterotopic ossification via fgfr3-bmpr1a pathway
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/98970981f1554eb68ed709ba30420a0f
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Targeting local lymphatics to ameliorate heterotopic ossification via FGFR3-BMPR1a pathway

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