Transcriptome-wide association study of attention deficit hyperactivity disorder identifies associated genes and phenotypes

A recent GWAS reported 12 genetic loci for attention deficit/hyperactivity disorder (ADHD). Here, Liao et al. perform transcriptomic imputation using these data and 12 brain-relevant tissues from GTEx and CMC to identify 9 genes associated with ADHD by TWAS, 3 of which had not yet been reported for...

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Autores principales:	Calwing Liao, Alexandre D. Laporte, Dan Spiegelman, Fulya Akçimen, Ridha Joober, Patrick A. Dion, Guy A. Rouleau
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/98989c48e5614c72b3a29f0f4c4ddced
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spelling	oai:doaj.org-article:98989c48e5614c72b3a29f0f4c4ddced2021-12-02T16:51:00ZTranscriptome-wide association study of attention deficit hyperactivity disorder identifies associated genes and phenotypes10.1038/s41467-019-12450-92041-1723https://doaj.org/article/98989c48e5614c72b3a29f0f4c4ddced2019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12450-9https://doaj.org/toc/2041-1723A recent GWAS reported 12 genetic loci for attention deficit/hyperactivity disorder (ADHD). Here, Liao et al. perform transcriptomic imputation using these data and 12 brain-relevant tissues from GTEx and CMC to identify 9 genes associated with ADHD by TWAS, 3 of which had not yet been reported for ADHD.Calwing LiaoAlexandre D. LaporteDan SpiegelmanFulya AkçimenRidha JooberPatrick A. DionGuy A. RouleauNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-7 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Calwing Liao Alexandre D. Laporte Dan Spiegelman Fulya Akçimen Ridha Joober Patrick A. Dion Guy A. Rouleau Transcriptome-wide association study of attention deficit hyperactivity disorder identifies associated genes and phenotypes
description	A recent GWAS reported 12 genetic loci for attention deficit/hyperactivity disorder (ADHD). Here, Liao et al. perform transcriptomic imputation using these data and 12 brain-relevant tissues from GTEx and CMC to identify 9 genes associated with ADHD by TWAS, 3 of which had not yet been reported for ADHD.
format	article
author	Calwing Liao Alexandre D. Laporte Dan Spiegelman Fulya Akçimen Ridha Joober Patrick A. Dion Guy A. Rouleau
author_facet	Calwing Liao Alexandre D. Laporte Dan Spiegelman Fulya Akçimen Ridha Joober Patrick A. Dion Guy A. Rouleau
author_sort	Calwing Liao
title	Transcriptome-wide association study of attention deficit hyperactivity disorder identifies associated genes and phenotypes
title_short	Transcriptome-wide association study of attention deficit hyperactivity disorder identifies associated genes and phenotypes
title_full	Transcriptome-wide association study of attention deficit hyperactivity disorder identifies associated genes and phenotypes
title_fullStr	Transcriptome-wide association study of attention deficit hyperactivity disorder identifies associated genes and phenotypes
title_full_unstemmed	Transcriptome-wide association study of attention deficit hyperactivity disorder identifies associated genes and phenotypes
title_sort	transcriptome-wide association study of attention deficit hyperactivity disorder identifies associated genes and phenotypes
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/98989c48e5614c72b3a29f0f4c4ddced
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Transcriptome-wide association study of attention deficit hyperactivity disorder identifies associated genes and phenotypes

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