Efficacy of Dipterocarpus alatus oil combination with Rhinacanthus nasutus leaf and Garcinia mangostana pericarps against canine demodicosis

Background and Aim: Canine demodicosis is a skin disease that is a major global health problem in dogs. Ivermectin is a drug of choice for treatment, but it may cause toxicity in dogs carrying multidrug resistance mutation-1 gene mutations. Hence, alternative herbal medicines are used instead of the...

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Autores principales:	Atchara Artchayasawat, Parichart Boueroy, Thidarut Boonmars, Benjamabhorn Pumhirunroj, Pranee Sriraj, Ratchadawan Aukkanimart, Sirintip Boonjaraspinyo, Opal Pitaksakulrat, Panaratana Ratanasuwan, Apiporn Suwannatrai, Chatanun Eamudomkarn, Porntip Laummaunwai, Wu Zhiliang
Formato:	article
Lenguaje:	EN
Publicado:	Veterinary World 2021
Materias:	demodicosis dipterocarpus alatus mangosteen pericarp treatment white crane flower Animal culture SF1-1100 Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/989fa0d6cadc48f6b28e0782d12e1d75
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spelling	oai:doaj.org-article:989fa0d6cadc48f6b28e0782d12e1d752021-11-16T11:24:33ZEfficacy of Dipterocarpus alatus oil combination with Rhinacanthus nasutus leaf and Garcinia mangostana pericarps against canine demodicosis10.14202/vetworld.2021.2919-29280972-89882231-0916https://doaj.org/article/989fa0d6cadc48f6b28e0782d12e1d752021-11-01T00:00:00Zhttp://www.veterinaryworld.org/Vol.14/November-2021/11.pdfhttps://doaj.org/toc/0972-8988https://doaj.org/toc/2231-0916Background and Aim: Canine demodicosis is a skin disease that is a major global health problem in dogs. Ivermectin is a drug of choice for treatment, but it may cause toxicity in dogs carrying multidrug resistance mutation-1 gene mutations. Hence, alternative herbal medicines are used instead of the drug, such as Dipterocarpus alatus oil (YN oil), Rhinacanthus nasutus leaf (WC), and Garcinia mangostana pericarps (MG) extracts. This study aimed to determine the efficacy of D. alatus oil, R. nasutus leaf, and G. mangostana pericarp extracts on canine demodicosis in vivo. Materials and Methods: Twenty-five mixed-breed dogs with localized demodicosis were examined. Dogs were diagnosed with demodicosis through deep skin scraping and screened with the inclusion criteria. Five dogs of each group were treated in five treatment groups (ivermectin, YN oil, YN oil+WC, YN oil+MG, and YN oil+WC+MG) for 1 month. The individual dogs were clinically evaluated, and the dermatological lesions were monitored daily for 60 days. Results: Dermatological lesion improvement was predominantly observed in the group of dogs treated with YN oil+WC. This was evidenced by the disappearance of the hyperpigmentation and lichenification on day 28 post-treatment and alopecia on day 56 post-treatment. Moreover, no allergic or clinical signs were observed during treatment. Conclusion: YN oil+WC is an alternative herbal medicine that could be used for the treatment of localized canine demodicosis.Atchara ArtchayasawatParichart BoueroyThidarut BoonmarsBenjamabhorn PumhirunrojPranee SrirajRatchadawan AukkanimartSirintip BoonjaraspinyoOpal PitaksakulratPanaratana RatanasuwanApiporn SuwannatraiChatanun EamudomkarnPorntip LaummaunwaiWu ZhiliangVeterinary Worldarticledemodicosisdipterocarpus alatusmangosteen pericarptreatmentwhite crane flowerAnimal cultureSF1-1100Veterinary medicineSF600-1100ENVeterinary World, Vol 14, Iss 11, Pp 2919-2928 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	demodicosis dipterocarpus alatus mangosteen pericarp treatment white crane flower Animal culture SF1-1100 Veterinary medicine SF600-1100
spellingShingle	demodicosis dipterocarpus alatus mangosteen pericarp treatment white crane flower Animal culture SF1-1100 Veterinary medicine SF600-1100 Atchara Artchayasawat Parichart Boueroy Thidarut Boonmars Benjamabhorn Pumhirunroj Pranee Sriraj Ratchadawan Aukkanimart Sirintip Boonjaraspinyo Opal Pitaksakulrat Panaratana Ratanasuwan Apiporn Suwannatrai Chatanun Eamudomkarn Porntip Laummaunwai Wu Zhiliang Efficacy of Dipterocarpus alatus oil combination with Rhinacanthus nasutus leaf and Garcinia mangostana pericarps against canine demodicosis
description	Background and Aim: Canine demodicosis is a skin disease that is a major global health problem in dogs. Ivermectin is a drug of choice for treatment, but it may cause toxicity in dogs carrying multidrug resistance mutation-1 gene mutations. Hence, alternative herbal medicines are used instead of the drug, such as Dipterocarpus alatus oil (YN oil), Rhinacanthus nasutus leaf (WC), and Garcinia mangostana pericarps (MG) extracts. This study aimed to determine the efficacy of D. alatus oil, R. nasutus leaf, and G. mangostana pericarp extracts on canine demodicosis in vivo. Materials and Methods: Twenty-five mixed-breed dogs with localized demodicosis were examined. Dogs were diagnosed with demodicosis through deep skin scraping and screened with the inclusion criteria. Five dogs of each group were treated in five treatment groups (ivermectin, YN oil, YN oil+WC, YN oil+MG, and YN oil+WC+MG) for 1 month. The individual dogs were clinically evaluated, and the dermatological lesions were monitored daily for 60 days. Results: Dermatological lesion improvement was predominantly observed in the group of dogs treated with YN oil+WC. This was evidenced by the disappearance of the hyperpigmentation and lichenification on day 28 post-treatment and alopecia on day 56 post-treatment. Moreover, no allergic or clinical signs were observed during treatment. Conclusion: YN oil+WC is an alternative herbal medicine that could be used for the treatment of localized canine demodicosis.
format	article
author	Atchara Artchayasawat Parichart Boueroy Thidarut Boonmars Benjamabhorn Pumhirunroj Pranee Sriraj Ratchadawan Aukkanimart Sirintip Boonjaraspinyo Opal Pitaksakulrat Panaratana Ratanasuwan Apiporn Suwannatrai Chatanun Eamudomkarn Porntip Laummaunwai Wu Zhiliang
author_facet	Atchara Artchayasawat Parichart Boueroy Thidarut Boonmars Benjamabhorn Pumhirunroj Pranee Sriraj Ratchadawan Aukkanimart Sirintip Boonjaraspinyo Opal Pitaksakulrat Panaratana Ratanasuwan Apiporn Suwannatrai Chatanun Eamudomkarn Porntip Laummaunwai Wu Zhiliang
author_sort	Atchara Artchayasawat
title	Efficacy of Dipterocarpus alatus oil combination with Rhinacanthus nasutus leaf and Garcinia mangostana pericarps against canine demodicosis
title_short	Efficacy of Dipterocarpus alatus oil combination with Rhinacanthus nasutus leaf and Garcinia mangostana pericarps against canine demodicosis
title_full	Efficacy of Dipterocarpus alatus oil combination with Rhinacanthus nasutus leaf and Garcinia mangostana pericarps against canine demodicosis
title_fullStr	Efficacy of Dipterocarpus alatus oil combination with Rhinacanthus nasutus leaf and Garcinia mangostana pericarps against canine demodicosis
title_full_unstemmed	Efficacy of Dipterocarpus alatus oil combination with Rhinacanthus nasutus leaf and Garcinia mangostana pericarps against canine demodicosis
title_sort	efficacy of dipterocarpus alatus oil combination with rhinacanthus nasutus leaf and garcinia mangostana pericarps against canine demodicosis
publisher	Veterinary World
publishDate	2021
url	https://doaj.org/article/989fa0d6cadc48f6b28e0782d12e1d75
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Efficacy of Dipterocarpus alatus oil combination with Rhinacanthus nasutus leaf and Garcinia mangostana pericarps against canine demodicosis

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