Factor XIIIA—expressing inflammatory monocytes promote lung squamous cancer through fibrin cross-linking

Factor XIIIA—expressing inflammatory monocytes promote lung squamous cancer through fibrin cross-linking

Lung squamous carcinomas (LUSC) are poorly molecularly characterized, but sub-populations show promising response to immune checkpoint inhibitors. Here, the authors identify a subset of LUSC characterized by infiltration of inflammatory monocytes, where metastasis is linked to Factor XIIIA promoting...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Alessandro Porrello, Patrick L. Leslie, Emily B. Harrison, Balachandra K. Gorentla, Sravya Kattula, Subrata K. Ghosh, Salma H. Azam, Alisha Holtzhausen, Yvonne L. Chao, Michele C. Hayward, Trent A. Waugh, Sanggyu Bae, Virginia Godfrey, Scott H. Randell, Cecilia Oderup, Liza Makowski, Jared Weiss, Matthew D. Wilkerson, D. Neil Hayes, H. Shelton Earp, Albert S. Baldwin, Alisa S. Wolberg, Chad V. Pecot
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/98a06355bdd34530b4587e1a8b9d1ffe
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:98a06355bdd34530b4587e1a8b9d1ffe
record_format dspace
spelling oai:doaj.org-article:98a06355bdd34530b4587e1a8b9d1ffe2021-12-02T15:33:38ZFactor XIIIA—expressing inflammatory monocytes promote lung squamous cancer through fibrin cross-linking10.1038/s41467-018-04355-w2041-1723https://doaj.org/article/98a06355bdd34530b4587e1a8b9d1ffe2018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04355-whttps://doaj.org/toc/2041-1723Lung squamous carcinomas (LUSC) are poorly molecularly characterized, but sub-populations show promising response to immune checkpoint inhibitors. Here, the authors identify a subset of LUSC characterized by infiltration of inflammatory monocytes, where metastasis is linked to Factor XIIIA promoting fibrin cross-linking.Alessandro PorrelloPatrick L. LeslieEmily B. HarrisonBalachandra K. GorentlaSravya KattulaSubrata K. GhoshSalma H. AzamAlisha HoltzhausenYvonne L. ChaoMichele C. HaywardTrent A. WaughSanggyu BaeVirginia GodfreyScott H. RandellCecilia OderupLiza MakowskiJared WeissMatthew D. WilkersonD. Neil HayesH. Shelton EarpAlbert S. BaldwinAlisa S. WolbergChad V. PecotNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-19 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Alessandro Porrello
Patrick L. Leslie
Emily B. Harrison
Balachandra K. Gorentla
Sravya Kattula
Subrata K. Ghosh
Salma H. Azam
Alisha Holtzhausen
Yvonne L. Chao
Michele C. Hayward
Trent A. Waugh
Sanggyu Bae
Virginia Godfrey
Scott H. Randell
Cecilia Oderup
Liza Makowski
Jared Weiss
Matthew D. Wilkerson
D. Neil Hayes
H. Shelton Earp
Albert S. Baldwin
Alisa S. Wolberg
Chad V. Pecot
Factor XIIIA—expressing inflammatory monocytes promote lung squamous cancer through fibrin cross-linking
description Lung squamous carcinomas (LUSC) are poorly molecularly characterized, but sub-populations show promising response to immune checkpoint inhibitors. Here, the authors identify a subset of LUSC characterized by infiltration of inflammatory monocytes, where metastasis is linked to Factor XIIIA promoting fibrin cross-linking.
format article
author Alessandro Porrello
Patrick L. Leslie
Emily B. Harrison
Balachandra K. Gorentla
Sravya Kattula
Subrata K. Ghosh
Salma H. Azam
Alisha Holtzhausen
Yvonne L. Chao
Michele C. Hayward
Trent A. Waugh
Sanggyu Bae
Virginia Godfrey
Scott H. Randell
Cecilia Oderup
Liza Makowski
Jared Weiss
Matthew D. Wilkerson
D. Neil Hayes
H. Shelton Earp
Albert S. Baldwin
Alisa S. Wolberg
Chad V. Pecot
author_facet Alessandro Porrello
Patrick L. Leslie
Emily B. Harrison
Balachandra K. Gorentla
Sravya Kattula
Subrata K. Ghosh
Salma H. Azam
Alisha Holtzhausen
Yvonne L. Chao
Michele C. Hayward
Trent A. Waugh
Sanggyu Bae
Virginia Godfrey
Scott H. Randell
Cecilia Oderup
Liza Makowski
Jared Weiss
Matthew D. Wilkerson
D. Neil Hayes
H. Shelton Earp
Albert S. Baldwin
Alisa S. Wolberg
Chad V. Pecot
author_sort Alessandro Porrello
title Factor XIIIA—expressing inflammatory monocytes promote lung squamous cancer through fibrin cross-linking
title_short Factor XIIIA—expressing inflammatory monocytes promote lung squamous cancer through fibrin cross-linking
title_full Factor XIIIA—expressing inflammatory monocytes promote lung squamous cancer through fibrin cross-linking
title_fullStr Factor XIIIA—expressing inflammatory monocytes promote lung squamous cancer through fibrin cross-linking
title_full_unstemmed Factor XIIIA—expressing inflammatory monocytes promote lung squamous cancer through fibrin cross-linking
title_sort factor xiiia—expressing inflammatory monocytes promote lung squamous cancer through fibrin cross-linking
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/98a06355bdd34530b4587e1a8b9d1ffe
work_keys_str_mv AT alessandroporrello factorxiiiaexpressinginflammatorymonocytespromotelungsquamouscancerthroughfibrincrosslinking
AT patricklleslie factorxiiiaexpressinginflammatorymonocytespromotelungsquamouscancerthroughfibrincrosslinking
AT emilybharrison factorxiiiaexpressinginflammatorymonocytespromotelungsquamouscancerthroughfibrincrosslinking
AT balachandrakgorentla factorxiiiaexpressinginflammatorymonocytespromotelungsquamouscancerthroughfibrincrosslinking
AT sravyakattula factorxiiiaexpressinginflammatorymonocytespromotelungsquamouscancerthroughfibrincrosslinking
AT subratakghosh factorxiiiaexpressinginflammatorymonocytespromotelungsquamouscancerthroughfibrincrosslinking
AT salmahazam factorxiiiaexpressinginflammatorymonocytespromotelungsquamouscancerthroughfibrincrosslinking
AT alishaholtzhausen factorxiiiaexpressinginflammatorymonocytespromotelungsquamouscancerthroughfibrincrosslinking
AT yvonnelchao factorxiiiaexpressinginflammatorymonocytespromotelungsquamouscancerthroughfibrincrosslinking
AT michelechayward factorxiiiaexpressinginflammatorymonocytespromotelungsquamouscancerthroughfibrincrosslinking
AT trentawaugh factorxiiiaexpressinginflammatorymonocytespromotelungsquamouscancerthroughfibrincrosslinking
AT sanggyubae factorxiiiaexpressinginflammatorymonocytespromotelungsquamouscancerthroughfibrincrosslinking
AT virginiagodfrey factorxiiiaexpressinginflammatorymonocytespromotelungsquamouscancerthroughfibrincrosslinking
AT scotthrandell factorxiiiaexpressinginflammatorymonocytespromotelungsquamouscancerthroughfibrincrosslinking
AT ceciliaoderup factorxiiiaexpressinginflammatorymonocytespromotelungsquamouscancerthroughfibrincrosslinking
AT lizamakowski factorxiiiaexpressinginflammatorymonocytespromotelungsquamouscancerthroughfibrincrosslinking
AT jaredweiss factorxiiiaexpressinginflammatorymonocytespromotelungsquamouscancerthroughfibrincrosslinking
AT matthewdwilkerson factorxiiiaexpressinginflammatorymonocytespromotelungsquamouscancerthroughfibrincrosslinking
AT dneilhayes factorxiiiaexpressinginflammatorymonocytespromotelungsquamouscancerthroughfibrincrosslinking
AT hsheltonearp factorxiiiaexpressinginflammatorymonocytespromotelungsquamouscancerthroughfibrincrosslinking
AT albertsbaldwin factorxiiiaexpressinginflammatorymonocytespromotelungsquamouscancerthroughfibrincrosslinking
AT alisaswolberg factorxiiiaexpressinginflammatorymonocytespromotelungsquamouscancerthroughfibrincrosslinking
AT chadvpecot factorxiiiaexpressinginflammatorymonocytespromotelungsquamouscancerthroughfibrincrosslinking
_version_ 1718387096195956736

Ejemplares similares