Short communication: carboxylate functionalized superparamagnetic iron oxide nanoparticles (SPION) for the reduction of S. aureus growth post biofilm formation

Kohana D Leuba, Naside Gozde Durmus, Erik N Taylor, Thomas J WebsterThe Nanomedicine Laboratory, School of Engineering, Brown University, Providence, RI, USAAbstract: Biofilms formed by antibiotic resistant Staphylococcus aureus (S. aureus) continue to be a problem for medical devices. Antibiotic re...

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Autores principales:	Leuba KD, Durmus NG, Taylor EN, Webster TJ
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/98a1e5da86044603810024642fa7ff71
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spelling	oai:doaj.org-article:98a1e5da86044603810024642fa7ff712021-12-02T04:33:09ZShort communication: carboxylate functionalized superparamagnetic iron oxide nanoparticles (SPION) for the reduction of S. aureus growth post biofilm formation1176-91141178-2013https://doaj.org/article/98a1e5da86044603810024642fa7ff712013-02-01T00:00:00Zhttp://www.dovepress.com/short-communication-carboxylate-functionalized-superparamagnetic-iron--a12260https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Kohana D Leuba, Naside Gozde Durmus, Erik N Taylor, Thomas J WebsterThe Nanomedicine Laboratory, School of Engineering, Brown University, Providence, RI, USAAbstract: Biofilms formed by antibiotic resistant Staphylococcus aureus (S. aureus) continue to be a problem for medical devices. Antibiotic resistant bacteria (such as S. aureus) often complicate the treatment and healing of the patient, yet, medical devices are needed to heal such patients. Therefore, methods to treat these biofilms once formed on medical devices are badly needed. Due to their small size and magnetic properties, superparamagnetic iron oxide nanoparticles (SPION) may be one possible material to penetrate biofilms and kill or slow the growth of bacteria. In this study, SPION were functionalized with amine, carboxylate, and isocyanate functional groups to further improve their efficacy to disrupt the growth of S. aureus biofilms. Without the use of antibiotics, results showed that SPION functionalized with carboxylate groups (followed by isocyanate then amine functional groups then unfunctionalized SPION) significantly disrupted biofilms and retarded the growth of S. aureus compared to untreated biofilms (by over 35% after 24 hours).Keywords: antibacterial, medical device infection, nanoparticle, iron oxide, biofilm, S. aureusLeuba KDDurmus NGTaylor ENWebster TJDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2013, Iss default, Pp 731-736 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Leuba KD Durmus NG Taylor EN Webster TJ Short communication: carboxylate functionalized superparamagnetic iron oxide nanoparticles (SPION) for the reduction of S. aureus growth post biofilm formation
description	Kohana D Leuba, Naside Gozde Durmus, Erik N Taylor, Thomas J WebsterThe Nanomedicine Laboratory, School of Engineering, Brown University, Providence, RI, USAAbstract: Biofilms formed by antibiotic resistant Staphylococcus aureus (S. aureus) continue to be a problem for medical devices. Antibiotic resistant bacteria (such as S. aureus) often complicate the treatment and healing of the patient, yet, medical devices are needed to heal such patients. Therefore, methods to treat these biofilms once formed on medical devices are badly needed. Due to their small size and magnetic properties, superparamagnetic iron oxide nanoparticles (SPION) may be one possible material to penetrate biofilms and kill or slow the growth of bacteria. In this study, SPION were functionalized with amine, carboxylate, and isocyanate functional groups to further improve their efficacy to disrupt the growth of S. aureus biofilms. Without the use of antibiotics, results showed that SPION functionalized with carboxylate groups (followed by isocyanate then amine functional groups then unfunctionalized SPION) significantly disrupted biofilms and retarded the growth of S. aureus compared to untreated biofilms (by over 35% after 24 hours).Keywords: antibacterial, medical device infection, nanoparticle, iron oxide, biofilm, S. aureus
format	article
author	Leuba KD Durmus NG Taylor EN Webster TJ
author_facet	Leuba KD Durmus NG Taylor EN Webster TJ
author_sort	Leuba KD
title	Short communication: carboxylate functionalized superparamagnetic iron oxide nanoparticles (SPION) for the reduction of S. aureus growth post biofilm formation
title_short	Short communication: carboxylate functionalized superparamagnetic iron oxide nanoparticles (SPION) for the reduction of S. aureus growth post biofilm formation
title_full	Short communication: carboxylate functionalized superparamagnetic iron oxide nanoparticles (SPION) for the reduction of S. aureus growth post biofilm formation
title_fullStr	Short communication: carboxylate functionalized superparamagnetic iron oxide nanoparticles (SPION) for the reduction of S. aureus growth post biofilm formation
title_full_unstemmed	Short communication: carboxylate functionalized superparamagnetic iron oxide nanoparticles (SPION) for the reduction of S. aureus growth post biofilm formation
title_sort	short communication: carboxylate functionalized superparamagnetic iron oxide nanoparticles (spion) for the reduction of s. aureus growth post biofilm formation
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/98a1e5da86044603810024642fa7ff71
work_keys_str_mv	AT leubakd shortcommunicationcarboxylatefunctionalizedsuperparamagneticironoxidenanoparticlesspionforthereductionofsaureusgrowthpostbiofilmformation AT durmusng shortcommunicationcarboxylatefunctionalizedsuperparamagneticironoxidenanoparticlesspionforthereductionofsaureusgrowthpostbiofilmformation AT tayloren shortcommunicationcarboxylatefunctionalizedsuperparamagneticironoxidenanoparticlesspionforthereductionofsaureusgrowthpostbiofilmformation AT webstertj shortcommunicationcarboxylatefunctionalizedsuperparamagneticironoxidenanoparticlesspionforthereductionofsaureusgrowthpostbiofilmformation
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Short communication: carboxylate functionalized superparamagnetic iron oxide nanoparticles (SPION) for the reduction of S. aureus growth post biofilm formation

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