Neuronal oscillations enhance stimulus discrimination by ensuring action potential precision.

Although oscillations in membrane potential are a prominent feature of sensory, motor, and cognitive function, their precise role in signal processing remains elusive. Here we show, using a combination of in vivo, in vitro, and theoretical approaches, that both synaptically and intrinsically generat...

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Autores principales:	Andreas T Schaefer, Kamilla Angelo, Hartwig Spors, Troy W Margrie
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2006
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/98a36ecee7294190a1bcd2535b9f8da9
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id	oai:doaj.org-article:98a36ecee7294190a1bcd2535b9f8da9
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spelling	oai:doaj.org-article:98a36ecee7294190a1bcd2535b9f8da92021-11-25T05:33:08ZNeuronal oscillations enhance stimulus discrimination by ensuring action potential precision.1544-91731545-788510.1371/journal.pbio.0040163https://doaj.org/article/98a36ecee7294190a1bcd2535b9f8da92006-06-01T00:00:00Zhttps://doi.org/10.1371/journal.pbio.0040163https://doaj.org/toc/1544-9173https://doaj.org/toc/1545-7885Although oscillations in membrane potential are a prominent feature of sensory, motor, and cognitive function, their precise role in signal processing remains elusive. Here we show, using a combination of in vivo, in vitro, and theoretical approaches, that both synaptically and intrinsically generated membrane potential oscillations dramatically improve action potential (AP) precision by removing the membrane potential variance associated with jitter-accumulating trains of APs. This increased AP precision occurred irrespective of cell type and--at oscillation frequencies ranging from 3 to 65 Hz--permitted accurate discernment of up to 1,000 different stimuli. At low oscillation frequencies, stimulus discrimination showed a clear phase dependence whereby inputs arriving during the trough and the early rising phase of an oscillation cycle were most robustly discriminated. Thus, by ensuring AP precision, membrane potential oscillations dramatically enhance the discriminatory capabilities of individual neurons and networks of cells and provide one attractive explanation for their abundance in neurophysiological systems.Andreas T SchaeferKamilla AngeloHartwig SporsTroy W MargriePublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Biology, Vol 4, Iss 6, p e163 (2006)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Andreas T Schaefer Kamilla Angelo Hartwig Spors Troy W Margrie Neuronal oscillations enhance stimulus discrimination by ensuring action potential precision.
description	Although oscillations in membrane potential are a prominent feature of sensory, motor, and cognitive function, their precise role in signal processing remains elusive. Here we show, using a combination of in vivo, in vitro, and theoretical approaches, that both synaptically and intrinsically generated membrane potential oscillations dramatically improve action potential (AP) precision by removing the membrane potential variance associated with jitter-accumulating trains of APs. This increased AP precision occurred irrespective of cell type and--at oscillation frequencies ranging from 3 to 65 Hz--permitted accurate discernment of up to 1,000 different stimuli. At low oscillation frequencies, stimulus discrimination showed a clear phase dependence whereby inputs arriving during the trough and the early rising phase of an oscillation cycle were most robustly discriminated. Thus, by ensuring AP precision, membrane potential oscillations dramatically enhance the discriminatory capabilities of individual neurons and networks of cells and provide one attractive explanation for their abundance in neurophysiological systems.
format	article
author	Andreas T Schaefer Kamilla Angelo Hartwig Spors Troy W Margrie
author_facet	Andreas T Schaefer Kamilla Angelo Hartwig Spors Troy W Margrie
author_sort	Andreas T Schaefer
title	Neuronal oscillations enhance stimulus discrimination by ensuring action potential precision.
title_short	Neuronal oscillations enhance stimulus discrimination by ensuring action potential precision.
title_full	Neuronal oscillations enhance stimulus discrimination by ensuring action potential precision.
title_fullStr	Neuronal oscillations enhance stimulus discrimination by ensuring action potential precision.
title_full_unstemmed	Neuronal oscillations enhance stimulus discrimination by ensuring action potential precision.
title_sort	neuronal oscillations enhance stimulus discrimination by ensuring action potential precision.
publisher	Public Library of Science (PLoS)
publishDate	2006
url	https://doaj.org/article/98a36ecee7294190a1bcd2535b9f8da9
work_keys_str_mv	AT andreastschaefer neuronaloscillationsenhancestimulusdiscriminationbyensuringactionpotentialprecision AT kamillaangelo neuronaloscillationsenhancestimulusdiscriminationbyensuringactionpotentialprecision AT hartwigspors neuronaloscillationsenhancestimulusdiscriminationbyensuringactionpotentialprecision AT troywmargrie neuronaloscillationsenhancestimulusdiscriminationbyensuringactionpotentialprecision
_version_	1718414652009873408

Neuronal oscillations enhance stimulus discrimination by ensuring action potential precision.

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