Disinfection effects of undoped and silver-doped ceria powders of nanometer crystallite size

Dah-Shyang Tsai,1 Tzu-Sen Yang,2,3 Yu-Sheng Huang,1 Pei-Wen Peng,2,4 Keng-Liang Ou3,4 1Department of Chemical Engineering, National Taiwan University of Science and Technology, 2School of Dental Technology, 3Graduate Institute of Biomedical Materials and Tissue Engineering, 4Research Center for Bio...

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Autores principales:	Tsai DS, Yang TS, Huang YS, Peng PW, Ou KL
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	ceria nanoparticle antibacterial activity cytotoxicity oxygen vacancy reactive oxygen species Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/98a775a56e654ce6a77469f2f5d3a67e
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spelling	oai:doaj.org-article:98a775a56e654ce6a77469f2f5d3a67e2021-12-02T05:08:59ZDisinfection effects of undoped and silver-doped ceria powders of nanometer crystallite size1178-2013https://doaj.org/article/98a775a56e654ce6a77469f2f5d3a67e2016-06-01T00:00:00Zhttps://www.dovepress.com/disinfection-effects-of-undoped-and-silver-doped-ceria-powders-of-nano-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Dah-Shyang Tsai,1 Tzu-Sen Yang,2,3 Yu-Sheng Huang,1 Pei-Wen Peng,2,4 Keng-Liang Ou3,4 1Department of Chemical Engineering, National Taiwan University of Science and Technology, 2School of Dental Technology, 3Graduate Institute of Biomedical Materials and Tissue Engineering, 4Research Center for Biomedical Implants and Microsurgery Devices, Taipei Medical University, Taipei, Taiwan Abstract: Being endowed with an ability of capturing and releasing oxygen, the ceria surface conventionally assumes the role of catalyzing redox reactions in chemistry. This catalytic effect also makes possible its cytotoxicity toward microorganisms at room temperature. To study this cytotoxicity, we synthesized the doped and undoped ceria particles of 8–9 nm in size using an inexpensive precipitation method and evaluated their disinfecting aptitudes with the turbidimetric and plate count methods. Among the samples being analyzed, the silver-doped ceria exhibits the highest sterilization ability, yet the undoped ceria is the most intriguing. The disinfection effect of undoped ceria is moderate in magnitude, demanding a physical contact between the ceria surface and bacteria cell wall, or the redox catalysis that can damage the cell wall and result in the cell killing. Evidently, this effect is short-range and depends strongly on dispersion of the nanoparticles. In contrast, the disinfection effects of silver-doped ceria reach out several millimeters since it releases silver ions to poison the surrounding microorganisms. Additionally, the aliovalent silver substitution creates more ceria defects. The synergetic combination, silver poisoning and heterogeneous redox catalysis, lifts and extends the disinfecting capability of silver-doped ceria to a superior level. Keywords: ceria nanoparticle, antibacterial activity, cytotoxicity, oxygen vacancy, reactive oxygen speciesTsai DSYang TSHuang YSPeng PWOu KLDove Medical Pressarticleceria nanoparticleantibacterial activitycytotoxicityoxygen vacancyreactive oxygen speciesMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2016, Iss default, Pp 2531-2542 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	ceria nanoparticle antibacterial activity cytotoxicity oxygen vacancy reactive oxygen species Medicine (General) R5-920
spellingShingle	ceria nanoparticle antibacterial activity cytotoxicity oxygen vacancy reactive oxygen species Medicine (General) R5-920 Tsai DS Yang TS Huang YS Peng PW Ou KL Disinfection effects of undoped and silver-doped ceria powders of nanometer crystallite size
description	Dah-Shyang Tsai,1 Tzu-Sen Yang,2,3 Yu-Sheng Huang,1 Pei-Wen Peng,2,4 Keng-Liang Ou3,4 1Department of Chemical Engineering, National Taiwan University of Science and Technology, 2School of Dental Technology, 3Graduate Institute of Biomedical Materials and Tissue Engineering, 4Research Center for Biomedical Implants and Microsurgery Devices, Taipei Medical University, Taipei, Taiwan Abstract: Being endowed with an ability of capturing and releasing oxygen, the ceria surface conventionally assumes the role of catalyzing redox reactions in chemistry. This catalytic effect also makes possible its cytotoxicity toward microorganisms at room temperature. To study this cytotoxicity, we synthesized the doped and undoped ceria particles of 8–9 nm in size using an inexpensive precipitation method and evaluated their disinfecting aptitudes with the turbidimetric and plate count methods. Among the samples being analyzed, the silver-doped ceria exhibits the highest sterilization ability, yet the undoped ceria is the most intriguing. The disinfection effect of undoped ceria is moderate in magnitude, demanding a physical contact between the ceria surface and bacteria cell wall, or the redox catalysis that can damage the cell wall and result in the cell killing. Evidently, this effect is short-range and depends strongly on dispersion of the nanoparticles. In contrast, the disinfection effects of silver-doped ceria reach out several millimeters since it releases silver ions to poison the surrounding microorganisms. Additionally, the aliovalent silver substitution creates more ceria defects. The synergetic combination, silver poisoning and heterogeneous redox catalysis, lifts and extends the disinfecting capability of silver-doped ceria to a superior level. Keywords: ceria nanoparticle, antibacterial activity, cytotoxicity, oxygen vacancy, reactive oxygen species
format	article
author	Tsai DS Yang TS Huang YS Peng PW Ou KL
author_facet	Tsai DS Yang TS Huang YS Peng PW Ou KL
author_sort	Tsai DS
title	Disinfection effects of undoped and silver-doped ceria powders of nanometer crystallite size
title_short	Disinfection effects of undoped and silver-doped ceria powders of nanometer crystallite size
title_full	Disinfection effects of undoped and silver-doped ceria powders of nanometer crystallite size
title_fullStr	Disinfection effects of undoped and silver-doped ceria powders of nanometer crystallite size
title_full_unstemmed	Disinfection effects of undoped and silver-doped ceria powders of nanometer crystallite size
title_sort	disinfection effects of undoped and silver-doped ceria powders of nanometer crystallite size
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/98a775a56e654ce6a77469f2f5d3a67e
work_keys_str_mv	AT tsaids disinfectioneffectsofundopedandsilverdopedceriapowdersofnanometercrystallitesize AT yangts disinfectioneffectsofundopedandsilverdopedceriapowdersofnanometercrystallitesize AT huangys disinfectioneffectsofundopedandsilverdopedceriapowdersofnanometercrystallitesize AT pengpw disinfectioneffectsofundopedandsilverdopedceriapowdersofnanometercrystallitesize AT oukl disinfectioneffectsofundopedandsilverdopedceriapowdersofnanometercrystallitesize
_version_	1718400545607122944

Disinfection effects of undoped and silver-doped ceria powders of nanometer crystallite size

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