Potent neutralizing nanobodies resist convergent circulating variants of SARS-CoV-2 by targeting diverse and conserved epitopes

Highly potent neutralizing nanobodies (Nbs) are of great interest as potential COVID-19 therapeutics. Here, the authors show that potent neutralizing Nbs targeting the receptor binding domain (RBD) of the SARS-CoV-2 spike protein are also effective against convergent variants of concern of the virus...

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Autores principales:	Dapeng Sun, Zhe Sang, Yong Joon Kim, Yufei Xiang, Tomer Cohen, Anna K. Belford, Alexis Huet, James F. Conway, Ji Sun, Derek J. Taylor, Dina Schneidman-Duhovny, Cheng Zhang, Wei Huang, Yi Shi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/98aa4a733c5b42fb84aa2005c4550187
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spelling	oai:doaj.org-article:98aa4a733c5b42fb84aa2005c45501872021-12-02T16:35:42ZPotent neutralizing nanobodies resist convergent circulating variants of SARS-CoV-2 by targeting diverse and conserved epitopes10.1038/s41467-021-24963-32041-1723https://doaj.org/article/98aa4a733c5b42fb84aa2005c45501872021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24963-3https://doaj.org/toc/2041-1723Highly potent neutralizing nanobodies (Nbs) are of great interest as potential COVID-19 therapeutics. Here, the authors show that potent neutralizing Nbs targeting the receptor binding domain (RBD) of the SARS-CoV-2 spike protein are also effective against convergent variants of concern of the virus. They determine eight Nb-bound spike protein cryo-EM structures, classify the binding epitopes of the Nbs and discuss their neutralization mechanisms.Dapeng SunZhe SangYong Joon KimYufei XiangTomer CohenAnna K. BelfordAlexis HuetJames F. ConwayJi SunDerek J. TaylorDina Schneidman-DuhovnyCheng ZhangWei HuangYi ShiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Dapeng Sun Zhe Sang Yong Joon Kim Yufei Xiang Tomer Cohen Anna K. Belford Alexis Huet James F. Conway Ji Sun Derek J. Taylor Dina Schneidman-Duhovny Cheng Zhang Wei Huang Yi Shi Potent neutralizing nanobodies resist convergent circulating variants of SARS-CoV-2 by targeting diverse and conserved epitopes
description	Highly potent neutralizing nanobodies (Nbs) are of great interest as potential COVID-19 therapeutics. Here, the authors show that potent neutralizing Nbs targeting the receptor binding domain (RBD) of the SARS-CoV-2 spike protein are also effective against convergent variants of concern of the virus. They determine eight Nb-bound spike protein cryo-EM structures, classify the binding epitopes of the Nbs and discuss their neutralization mechanisms.
format	article
author	Dapeng Sun Zhe Sang Yong Joon Kim Yufei Xiang Tomer Cohen Anna K. Belford Alexis Huet James F. Conway Ji Sun Derek J. Taylor Dina Schneidman-Duhovny Cheng Zhang Wei Huang Yi Shi
author_facet	Dapeng Sun Zhe Sang Yong Joon Kim Yufei Xiang Tomer Cohen Anna K. Belford Alexis Huet James F. Conway Ji Sun Derek J. Taylor Dina Schneidman-Duhovny Cheng Zhang Wei Huang Yi Shi
author_sort	Dapeng Sun
title	Potent neutralizing nanobodies resist convergent circulating variants of SARS-CoV-2 by targeting diverse and conserved epitopes
title_short	Potent neutralizing nanobodies resist convergent circulating variants of SARS-CoV-2 by targeting diverse and conserved epitopes
title_full	Potent neutralizing nanobodies resist convergent circulating variants of SARS-CoV-2 by targeting diverse and conserved epitopes
title_fullStr	Potent neutralizing nanobodies resist convergent circulating variants of SARS-CoV-2 by targeting diverse and conserved epitopes
title_full_unstemmed	Potent neutralizing nanobodies resist convergent circulating variants of SARS-CoV-2 by targeting diverse and conserved epitopes
title_sort	potent neutralizing nanobodies resist convergent circulating variants of sars-cov-2 by targeting diverse and conserved epitopes
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/98aa4a733c5b42fb84aa2005c4550187
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Potent neutralizing nanobodies resist convergent circulating variants of SARS-CoV-2 by targeting diverse and conserved epitopes

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