Mapping the breast cancer metastatic cascade onto ctDNA using genetic and epigenetic clonal tracking

Tracking tumour evolution in a patient via circulating tumour DNA (ctDNA) is complicated due to the unknown mix of fragmented alleles from different cancer lesions. Here, the authors make use of a rapid autopsy program to demonstrate how representative ctDNA profiling is of metastasis, as well as pr...

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Autores principales:	George D. Cresswell, Daniel Nichol, Inmaculada Spiteri, Haider Tari, Luis Zapata, Timon Heide, Carlo C. Maley, Luca Magnani, Gaia Schiavon, Alan Ashworth, Peter Barry, Andrea Sottoriva
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/98ada904713047afa84798009c85187b
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spelling	oai:doaj.org-article:98ada904713047afa84798009c85187b2021-12-02T14:40:27ZMapping the breast cancer metastatic cascade onto ctDNA using genetic and epigenetic clonal tracking10.1038/s41467-020-15047-92041-1723https://doaj.org/article/98ada904713047afa84798009c85187b2020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15047-9https://doaj.org/toc/2041-1723Tracking tumour evolution in a patient via circulating tumour DNA (ctDNA) is complicated due to the unknown mix of fragmented alleles from different cancer lesions. Here, the authors make use of a rapid autopsy program to demonstrate how representative ctDNA profiling is of metastasis, as well as presenting methylation profiling method to track evolutionary change.George D. CresswellDaniel NicholInmaculada SpiteriHaider TariLuis ZapataTimon HeideCarlo C. MaleyLuca MagnaniGaia SchiavonAlan AshworthPeter BarryAndrea SottorivaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q George D. Cresswell Daniel Nichol Inmaculada Spiteri Haider Tari Luis Zapata Timon Heide Carlo C. Maley Luca Magnani Gaia Schiavon Alan Ashworth Peter Barry Andrea Sottoriva Mapping the breast cancer metastatic cascade onto ctDNA using genetic and epigenetic clonal tracking
description	Tracking tumour evolution in a patient via circulating tumour DNA (ctDNA) is complicated due to the unknown mix of fragmented alleles from different cancer lesions. Here, the authors make use of a rapid autopsy program to demonstrate how representative ctDNA profiling is of metastasis, as well as presenting methylation profiling method to track evolutionary change.
format	article
author	George D. Cresswell Daniel Nichol Inmaculada Spiteri Haider Tari Luis Zapata Timon Heide Carlo C. Maley Luca Magnani Gaia Schiavon Alan Ashworth Peter Barry Andrea Sottoriva
author_facet	George D. Cresswell Daniel Nichol Inmaculada Spiteri Haider Tari Luis Zapata Timon Heide Carlo C. Maley Luca Magnani Gaia Schiavon Alan Ashworth Peter Barry Andrea Sottoriva
author_sort	George D. Cresswell
title	Mapping the breast cancer metastatic cascade onto ctDNA using genetic and epigenetic clonal tracking
title_short	Mapping the breast cancer metastatic cascade onto ctDNA using genetic and epigenetic clonal tracking
title_full	Mapping the breast cancer metastatic cascade onto ctDNA using genetic and epigenetic clonal tracking
title_fullStr	Mapping the breast cancer metastatic cascade onto ctDNA using genetic and epigenetic clonal tracking
title_full_unstemmed	Mapping the breast cancer metastatic cascade onto ctDNA using genetic and epigenetic clonal tracking
title_sort	mapping the breast cancer metastatic cascade onto ctdna using genetic and epigenetic clonal tracking
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/98ada904713047afa84798009c85187b
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Mapping the breast cancer metastatic cascade onto ctDNA using genetic and epigenetic clonal tracking

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