Mapping the breast cancer metastatic cascade onto ctDNA using genetic and epigenetic clonal tracking

Mapping the breast cancer metastatic cascade onto ctDNA using genetic and epigenetic clonal tracking

Tracking tumour evolution in a patient via circulating tumour DNA (ctDNA) is complicated due to the unknown mix of fragmented alleles from different cancer lesions. Here, the authors make use of a rapid autopsy program to demonstrate how representative ctDNA profiling is of metastasis, as well as pr...

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Autores principales: George D. Cresswell, Daniel Nichol, Inmaculada Spiteri, Haider Tari, Luis Zapata, Timon Heide, Carlo C. Maley, Luca Magnani, Gaia Schiavon, Alan Ashworth, Peter Barry, Andrea Sottoriva
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Science
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Acceso en línea:https://doaj.org/article/98ada904713047afa84798009c85187b
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