Chimeric Vaccines Based on Novel Insect-Specific Flaviviruses

Vector-borne flaviviruses are responsible for nearly half a billion human infections worldwide each year, resulting in millions of cases of debilitating and severe diseases and approximately 115,000 deaths. While approved vaccines are available for some of these viruses, the ongoing efficacy, safety...

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Autores principales:	Jessica J. Harrison, Jody Hobson-Peters, Helle Bielefeldt-Ohmann, Roy A. Hall
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	flavivirus vaccine platform chimeric virus dengue yellow fever Japanese encephalitis Medicine R
Acceso en línea:	https://doaj.org/article/98b077beb5284b42814796a916b8e7fa
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id	oai:doaj.org-article:98b077beb5284b42814796a916b8e7fa
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spelling	oai:doaj.org-article:98b077beb5284b42814796a916b8e7fa2021-11-25T19:10:16ZChimeric Vaccines Based on Novel Insect-Specific Flaviviruses10.3390/vaccines91112302076-393Xhttps://doaj.org/article/98b077beb5284b42814796a916b8e7fa2021-10-01T00:00:00Zhttps://www.mdpi.com/2076-393X/9/11/1230https://doaj.org/toc/2076-393XVector-borne flaviviruses are responsible for nearly half a billion human infections worldwide each year, resulting in millions of cases of debilitating and severe diseases and approximately 115,000 deaths. While approved vaccines are available for some of these viruses, the ongoing efficacy, safety and supply of these vaccines are still a significant problem. New technologies that address these issues and ideally allow for the safe and economical manufacture of vaccines in resource-poor countries where flavivirus vaccines are in most demand are urgently required. Preferably a new vaccine platform would be broadly applicable to all flavivirus diseases and provide new candidate vaccines for those diseases not yet covered, as well as the flexibility to rapidly pivot to respond to newly emerged flavivirus diseases. Here, we review studies conducted on novel chimeric vaccines derived from insect-specific flaviviruses that provide a potentially safe and simple system to produce highly effective vaccines against a broad spectrum of flavivirus diseases.Jessica J. HarrisonJody Hobson-PetersHelle Bielefeldt-OhmannRoy A. HallMDPI AGarticleflavivirusvaccine platformchimeric virusdengueyellow feverJapanese encephalitisMedicineRENVaccines, Vol 9, Iss 1230, p 1230 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	flavivirus vaccine platform chimeric virus dengue yellow fever Japanese encephalitis Medicine R
spellingShingle	flavivirus vaccine platform chimeric virus dengue yellow fever Japanese encephalitis Medicine R Jessica J. Harrison Jody Hobson-Peters Helle Bielefeldt-Ohmann Roy A. Hall Chimeric Vaccines Based on Novel Insect-Specific Flaviviruses
description	Vector-borne flaviviruses are responsible for nearly half a billion human infections worldwide each year, resulting in millions of cases of debilitating and severe diseases and approximately 115,000 deaths. While approved vaccines are available for some of these viruses, the ongoing efficacy, safety and supply of these vaccines are still a significant problem. New technologies that address these issues and ideally allow for the safe and economical manufacture of vaccines in resource-poor countries where flavivirus vaccines are in most demand are urgently required. Preferably a new vaccine platform would be broadly applicable to all flavivirus diseases and provide new candidate vaccines for those diseases not yet covered, as well as the flexibility to rapidly pivot to respond to newly emerged flavivirus diseases. Here, we review studies conducted on novel chimeric vaccines derived from insect-specific flaviviruses that provide a potentially safe and simple system to produce highly effective vaccines against a broad spectrum of flavivirus diseases.
format	article
author	Jessica J. Harrison Jody Hobson-Peters Helle Bielefeldt-Ohmann Roy A. Hall
author_facet	Jessica J. Harrison Jody Hobson-Peters Helle Bielefeldt-Ohmann Roy A. Hall
author_sort	Jessica J. Harrison
title	Chimeric Vaccines Based on Novel Insect-Specific Flaviviruses
title_short	Chimeric Vaccines Based on Novel Insect-Specific Flaviviruses
title_full	Chimeric Vaccines Based on Novel Insect-Specific Flaviviruses
title_fullStr	Chimeric Vaccines Based on Novel Insect-Specific Flaviviruses
title_full_unstemmed	Chimeric Vaccines Based on Novel Insect-Specific Flaviviruses
title_sort	chimeric vaccines based on novel insect-specific flaviviruses
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/98b077beb5284b42814796a916b8e7fa
work_keys_str_mv	AT jessicajharrison chimericvaccinesbasedonnovelinsectspecificflaviviruses AT jodyhobsonpeters chimericvaccinesbasedonnovelinsectspecificflaviviruses AT hellebielefeldtohmann chimericvaccinesbasedonnovelinsectspecificflaviviruses AT royahall chimericvaccinesbasedonnovelinsectspecificflaviviruses
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Chimeric Vaccines Based on Novel Insect-Specific Flaviviruses

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