Neuronal SphK1 acetylates COX2 and contributes to pathogenesis in a model of Alzheimer’s Disease

Neuronal SphK1 acetylates COX2 and contributes to pathogenesis in a model of Alzheimer’s Disease

Sphingosine kinase (SphK) converts sphingosine into lipids, and is implicated in inflammation. Here the authors show that SphK1 functions as an acetyltransferase, regulates microglial phagocytosis and is reduced in a model of Alzheimer’s Disease, such that its restoration ameliorates pathology

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Autores principales: Ju Youn Lee, Seung Hoon Han, Min Hee Park, Bosung Baek, Im-Sook Song, Min-Koo Choi, Yoh Takuwa, Hoon Ryu, Seung Hyun Kim, Xingxuan He, Edward H. Schuchman, Jae-Sung Bae, Hee Kyung Jin
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/98b2523a54044a18a2edc80a341e1756
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spelling oai:doaj.org-article:98b2523a54044a18a2edc80a341e17562021-12-02T16:56:36ZNeuronal SphK1 acetylates COX2 and contributes to pathogenesis in a model of Alzheimer’s Disease10.1038/s41467-018-03674-22041-1723https://doaj.org/article/98b2523a54044a18a2edc80a341e17562018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03674-2https://doaj.org/toc/2041-1723Sphingosine kinase (SphK) converts sphingosine into lipids, and is implicated in inflammation. Here the authors show that SphK1 functions as an acetyltransferase, regulates microglial phagocytosis and is reduced in a model of Alzheimer’s Disease, such that its restoration ameliorates pathologyJu Youn LeeSeung Hoon HanMin Hee ParkBosung BaekIm-Sook SongMin-Koo ChoiYoh TakuwaHoon RyuSeung Hyun KimXingxuan HeEdward H. SchuchmanJae-Sung BaeHee Kyung JinNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Ju Youn Lee
Seung Hoon Han
Min Hee Park
Bosung Baek
Im-Sook Song
Min-Koo Choi
Yoh Takuwa
Hoon Ryu
Seung Hyun Kim
Xingxuan He
Edward H. Schuchman
Jae-Sung Bae
Hee Kyung Jin
Neuronal SphK1 acetylates COX2 and contributes to pathogenesis in a model of Alzheimer’s Disease
description Sphingosine kinase (SphK) converts sphingosine into lipids, and is implicated in inflammation. Here the authors show that SphK1 functions as an acetyltransferase, regulates microglial phagocytosis and is reduced in a model of Alzheimer’s Disease, such that its restoration ameliorates pathology
format article
author Ju Youn Lee
Seung Hoon Han
Min Hee Park
Bosung Baek
Im-Sook Song
Min-Koo Choi
Yoh Takuwa
Hoon Ryu
Seung Hyun Kim
Xingxuan He
Edward H. Schuchman
Jae-Sung Bae
Hee Kyung Jin
author_facet Ju Youn Lee
Seung Hoon Han
Min Hee Park
Bosung Baek
Im-Sook Song
Min-Koo Choi
Yoh Takuwa
Hoon Ryu
Seung Hyun Kim
Xingxuan He
Edward H. Schuchman
Jae-Sung Bae
Hee Kyung Jin
author_sort Ju Youn Lee
title Neuronal SphK1 acetylates COX2 and contributes to pathogenesis in a model of Alzheimer’s Disease
title_short Neuronal SphK1 acetylates COX2 and contributes to pathogenesis in a model of Alzheimer’s Disease
title_full Neuronal SphK1 acetylates COX2 and contributes to pathogenesis in a model of Alzheimer’s Disease
title_fullStr Neuronal SphK1 acetylates COX2 and contributes to pathogenesis in a model of Alzheimer’s Disease
title_full_unstemmed Neuronal SphK1 acetylates COX2 and contributes to pathogenesis in a model of Alzheimer’s Disease
title_sort neuronal sphk1 acetylates cox2 and contributes to pathogenesis in a model of alzheimer’s disease
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/98b2523a54044a18a2edc80a341e1756
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