Single event-related changes in cerebral oxygenated hemoglobin using word game in schizophrenia

Ryo Fujiki,1,2 Kiichiro Morita,1,2 Mamoru Sato,1,2 Yuji Yamashita,1,2 Yusuke Kato,1,2 Yohei Ishii,2 Yoshihisa Shoji,1,2 Naohisa Uchimura1 1Department of Neuropsychiatry, Kurume University, 2Cognitive and Molecular Research Institute of Brain Diseases, Kurume University School of Medicine, Kurume-C...

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Autores principales:	Fujiki R, Morita K, Sato M, Yamashita Y, Kato Y, Ishii Y, Shoji Y, Uchimura N
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/98b2c1b314764cf48d76e9fe34e1ac75
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spelling	oai:doaj.org-article:98b2c1b314764cf48d76e9fe34e1ac752021-12-02T02:11:30ZSingle event-related changes in cerebral oxygenated hemoglobin using word game in schizophrenia1178-2021https://doaj.org/article/98b2c1b314764cf48d76e9fe34e1ac752014-12-01T00:00:00Zhttp://www.dovepress.com/single-event-related-changes-in-cerebral-oxygenated-hemoglobin-using-w-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021 Ryo Fujiki,1,2 Kiichiro Morita,1,2 Mamoru Sato,1,2 Yuji Yamashita,1,2 Yusuke Kato,1,2 Yohei Ishii,2 Yoshihisa Shoji,1,2 Naohisa Uchimura1 1Department of Neuropsychiatry, Kurume University, 2Cognitive and Molecular Research Institute of Brain Diseases, Kurume University School of Medicine, Kurume-City, Japan Abstract: Neuroimaging studies have been conducted using word generation tasks and have shown greater hypofrontality in patients with schizophrenia compared with healthy subjects. In this study, we compared the characteristics of oxygenated hemoglobin changes involved in both phonological and categorical verbal fluency between 35 outpatients with schizophrenia and 35 healthy subjects during a Japanese “shiritori” task using single-event-related near-infrared spectroscopy. During this task, the schizophrenic patients showed significantly smaller activation in the prefrontal cortex area than the controls. In addition, a significant positive correlation was obtained between oxygenated hemoglobin changes (prefrontal cortex area, inferior parietal area) and the severity of positive psychiatric symptoms. It is possible that hypofrontality of patients may be a diagnostic assistance tool for schizophrenia, and that the relationship between activation and positive syndrome scores may be of help in predicting functional outcome in patients. Keywords: word production task, single-event-related near-infrared spectroscopy, schizophrenia, hypofrontality, biological markerFujiki RMorita KSato MYamashita YKato YIshii YShoji YUchimura NDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2014, Iss default, Pp 2353-2360 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Fujiki R Morita K Sato M Yamashita Y Kato Y Ishii Y Shoji Y Uchimura N Single event-related changes in cerebral oxygenated hemoglobin using word game in schizophrenia
description	Ryo Fujiki,1,2 Kiichiro Morita,1,2 Mamoru Sato,1,2 Yuji Yamashita,1,2 Yusuke Kato,1,2 Yohei Ishii,2 Yoshihisa Shoji,1,2 Naohisa Uchimura1 1Department of Neuropsychiatry, Kurume University, 2Cognitive and Molecular Research Institute of Brain Diseases, Kurume University School of Medicine, Kurume-City, Japan Abstract: Neuroimaging studies have been conducted using word generation tasks and have shown greater hypofrontality in patients with schizophrenia compared with healthy subjects. In this study, we compared the characteristics of oxygenated hemoglobin changes involved in both phonological and categorical verbal fluency between 35 outpatients with schizophrenia and 35 healthy subjects during a Japanese “shiritori” task using single-event-related near-infrared spectroscopy. During this task, the schizophrenic patients showed significantly smaller activation in the prefrontal cortex area than the controls. In addition, a significant positive correlation was obtained between oxygenated hemoglobin changes (prefrontal cortex area, inferior parietal area) and the severity of positive psychiatric symptoms. It is possible that hypofrontality of patients may be a diagnostic assistance tool for schizophrenia, and that the relationship between activation and positive syndrome scores may be of help in predicting functional outcome in patients. Keywords: word production task, single-event-related near-infrared spectroscopy, schizophrenia, hypofrontality, biological marker
format	article
author	Fujiki R Morita K Sato M Yamashita Y Kato Y Ishii Y Shoji Y Uchimura N
author_facet	Fujiki R Morita K Sato M Yamashita Y Kato Y Ishii Y Shoji Y Uchimura N
author_sort	Fujiki R
title	Single event-related changes in cerebral oxygenated hemoglobin using word game in schizophrenia
title_short	Single event-related changes in cerebral oxygenated hemoglobin using word game in schizophrenia
title_full	Single event-related changes in cerebral oxygenated hemoglobin using word game in schizophrenia
title_fullStr	Single event-related changes in cerebral oxygenated hemoglobin using word game in schizophrenia
title_full_unstemmed	Single event-related changes in cerebral oxygenated hemoglobin using word game in schizophrenia
title_sort	single event-related changes in cerebral oxygenated hemoglobin using word game in schizophrenia
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/98b2c1b314764cf48d76e9fe34e1ac75
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Single event-related changes in cerebral oxygenated hemoglobin using word game in&nbsp;schizophrenia

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Single event-related changes in cerebral oxygenated hemoglobin using word game in schizophrenia