Benefits of glioma resection in the corpus callosum

Abstract Due to anticipated postoperative neuropsychological sequelae, patients with gliomas infiltrating the corpus callosum rarely undergo tumor resection and mostly present in a poor neurological state. We aimed at investigating the benefit of glioma resection in the corpus callosum, hypothesizin...

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Autores principales:	Marie-Therese Forster, Marion Behrens, Irina Lortz, Nadine Conradi, Christian Senft, Martin Voss, Maximilian Rauch, Volker Seifert
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/98b4197d8b964f26989f8638aa1c0c4f
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spelling	oai:doaj.org-article:98b4197d8b964f26989f8638aa1c0c4f2021-12-02T18:37:07ZBenefits of glioma resection in the corpus callosum10.1038/s41598-020-73928-x2045-2322https://doaj.org/article/98b4197d8b964f26989f8638aa1c0c4f2020-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-73928-xhttps://doaj.org/toc/2045-2322Abstract Due to anticipated postoperative neuropsychological sequelae, patients with gliomas infiltrating the corpus callosum rarely undergo tumor resection and mostly present in a poor neurological state. We aimed at investigating the benefit of glioma resection in the corpus callosum, hypothesizing neuropsychological deficits were mainly caused by tumor presence. Between 01/2017 and 1/2020, 21 patients who underwent glioma resection in the corpus callosum were prospectively enrolled into this study. Neuropsychological function was assessed preoperatively, before discharge and after 6 months. Gross total tumor resection was possible in 15 patients, and in 6 patients subtotal tumor resection with a tumor reduction of 97.7% could be achieved. During a median observation time of 12.6 months 9 patients died from glioblastoma after a median of 17 months. Preoperatively, all cognitive domains were affected in up to two thirds of patients, who presented a median KPS of 100% (range 60–100%). After surgery, the proportion of impaired patients increased in all neurocognitive domains. Most interestingly, after 6 months, significantly fewer patients showed impairments in attention, executive functioning, memory and depression, which are domains considered crucial for everyday functionality. Thus, the results of our study strongly support our hypothesis that in patients with gliomas infiltrating the corpus callosum the benefit of tumor resection might outweigh morbidity.Marie-Therese ForsterMarion BehrensIrina LortzNadine ConradiChristian SenftMartin VossMaximilian RauchVolker SeifertNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Marie-Therese Forster Marion Behrens Irina Lortz Nadine Conradi Christian Senft Martin Voss Maximilian Rauch Volker Seifert Benefits of glioma resection in the corpus callosum
description	Abstract Due to anticipated postoperative neuropsychological sequelae, patients with gliomas infiltrating the corpus callosum rarely undergo tumor resection and mostly present in a poor neurological state. We aimed at investigating the benefit of glioma resection in the corpus callosum, hypothesizing neuropsychological deficits were mainly caused by tumor presence. Between 01/2017 and 1/2020, 21 patients who underwent glioma resection in the corpus callosum were prospectively enrolled into this study. Neuropsychological function was assessed preoperatively, before discharge and after 6 months. Gross total tumor resection was possible in 15 patients, and in 6 patients subtotal tumor resection with a tumor reduction of 97.7% could be achieved. During a median observation time of 12.6 months 9 patients died from glioblastoma after a median of 17 months. Preoperatively, all cognitive domains were affected in up to two thirds of patients, who presented a median KPS of 100% (range 60–100%). After surgery, the proportion of impaired patients increased in all neurocognitive domains. Most interestingly, after 6 months, significantly fewer patients showed impairments in attention, executive functioning, memory and depression, which are domains considered crucial for everyday functionality. Thus, the results of our study strongly support our hypothesis that in patients with gliomas infiltrating the corpus callosum the benefit of tumor resection might outweigh morbidity.
format	article
author	Marie-Therese Forster Marion Behrens Irina Lortz Nadine Conradi Christian Senft Martin Voss Maximilian Rauch Volker Seifert
author_facet	Marie-Therese Forster Marion Behrens Irina Lortz Nadine Conradi Christian Senft Martin Voss Maximilian Rauch Volker Seifert
author_sort	Marie-Therese Forster
title	Benefits of glioma resection in the corpus callosum
title_short	Benefits of glioma resection in the corpus callosum
title_full	Benefits of glioma resection in the corpus callosum
title_fullStr	Benefits of glioma resection in the corpus callosum
title_full_unstemmed	Benefits of glioma resection in the corpus callosum
title_sort	benefits of glioma resection in the corpus callosum
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/98b4197d8b964f26989f8638aa1c0c4f
work_keys_str_mv	AT mariethereseforster benefitsofgliomaresectioninthecorpuscallosum AT marionbehrens benefitsofgliomaresectioninthecorpuscallosum AT irinalortz benefitsofgliomaresectioninthecorpuscallosum AT nadineconradi benefitsofgliomaresectioninthecorpuscallosum AT christiansenft benefitsofgliomaresectioninthecorpuscallosum AT martinvoss benefitsofgliomaresectioninthecorpuscallosum AT maximilianrauch benefitsofgliomaresectioninthecorpuscallosum AT volkerseifert benefitsofgliomaresectioninthecorpuscallosum
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Benefits of glioma resection in the corpus callosum

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