Red Seaweed-Derived Compounds as a Potential New Approach for Acne Vulgaris Care

Acne vulgaris (AV) is a chronic skin disease of the pilosebaceous unit affecting both adolescents and adults. Its pathophysiology includes processes of inflammation, increased keratinization, sebum production, hormonal dysregulation, and bacterial <i>Cutibacterium acnes</i> proliferation...

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Autores principales:	Adriana P. Januário, Rafael Félix, Carina Félix, João Reboleira, Patrícia Valentão, Marco F. L. Lemos
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	acne pathophysiology antibacterial bioactive compounds <i>Cutibacterium acnes</i> inflammation Rhodophyta Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/98b56707c63147eeaff275218923639a
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spelling	oai:doaj.org-article:98b56707c63147eeaff275218923639a2021-11-25T18:42:00ZRed Seaweed-Derived Compounds as a Potential New Approach for Acne Vulgaris Care10.3390/pharmaceutics131119301999-4923https://doaj.org/article/98b56707c63147eeaff275218923639a2021-11-01T00:00:00Zhttps://www.mdpi.com/1999-4923/13/11/1930https://doaj.org/toc/1999-4923Acne vulgaris (AV) is a chronic skin disease of the pilosebaceous unit affecting both adolescents and adults. Its pathophysiology includes processes of inflammation, increased keratinization, sebum production, hormonal dysregulation, and bacterial <i>Cutibacterium acnes</i> proliferation. Common AV has been treated with antibiotics since the 1960s, but strain resistance has emerged and is of paramount concern. Macroalgae are known producers of substances with bioactive properties, including anti-viral, antibacterial, antioxidant, and anti-inflammatory properties, among several others. In particular, red algae are rich in bioactive compounds such as polysaccharides, phenolic compounds, lipids, sterols, alkaloids, and terpenoids, conferring them antioxidant, antimicrobial, and anti-inflammatory activities, among others. Thus, the exploration of compounds from marine resources can be an appealing approach to discover new treatment options against AV. The aim of this work is to provide an overview of the current knowledge of the potentialities of red macroalgae in the treatment of AV by reviewing the main therapeutic targets of this disease, and then the existence of compounds or extracts with bioactive properties against them.Adriana P. JanuárioRafael FélixCarina FélixJoão ReboleiraPatrícia ValentãoMarco F. L. LemosMDPI AGarticleacne pathophysiologyantibacterialbioactive compounds<i>Cutibacterium acnes</i>inflammationRhodophytaPharmacy and materia medicaRS1-441ENPharmaceutics, Vol 13, Iss 1930, p 1930 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	acne pathophysiology antibacterial bioactive compounds <i>Cutibacterium acnes</i> inflammation Rhodophyta Pharmacy and materia medica RS1-441
spellingShingle	acne pathophysiology antibacterial bioactive compounds <i>Cutibacterium acnes</i> inflammation Rhodophyta Pharmacy and materia medica RS1-441 Adriana P. Januário Rafael Félix Carina Félix João Reboleira Patrícia Valentão Marco F. L. Lemos Red Seaweed-Derived Compounds as a Potential New Approach for Acne Vulgaris Care
description	Acne vulgaris (AV) is a chronic skin disease of the pilosebaceous unit affecting both adolescents and adults. Its pathophysiology includes processes of inflammation, increased keratinization, sebum production, hormonal dysregulation, and bacterial <i>Cutibacterium acnes</i> proliferation. Common AV has been treated with antibiotics since the 1960s, but strain resistance has emerged and is of paramount concern. Macroalgae are known producers of substances with bioactive properties, including anti-viral, antibacterial, antioxidant, and anti-inflammatory properties, among several others. In particular, red algae are rich in bioactive compounds such as polysaccharides, phenolic compounds, lipids, sterols, alkaloids, and terpenoids, conferring them antioxidant, antimicrobial, and anti-inflammatory activities, among others. Thus, the exploration of compounds from marine resources can be an appealing approach to discover new treatment options against AV. The aim of this work is to provide an overview of the current knowledge of the potentialities of red macroalgae in the treatment of AV by reviewing the main therapeutic targets of this disease, and then the existence of compounds or extracts with bioactive properties against them.
format	article
author	Adriana P. Januário Rafael Félix Carina Félix João Reboleira Patrícia Valentão Marco F. L. Lemos
author_facet	Adriana P. Januário Rafael Félix Carina Félix João Reboleira Patrícia Valentão Marco F. L. Lemos
author_sort	Adriana P. Januário
title	Red Seaweed-Derived Compounds as a Potential New Approach for Acne Vulgaris Care
title_short	Red Seaweed-Derived Compounds as a Potential New Approach for Acne Vulgaris Care
title_full	Red Seaweed-Derived Compounds as a Potential New Approach for Acne Vulgaris Care
title_fullStr	Red Seaweed-Derived Compounds as a Potential New Approach for Acne Vulgaris Care
title_full_unstemmed	Red Seaweed-Derived Compounds as a Potential New Approach for Acne Vulgaris Care
title_sort	red seaweed-derived compounds as a potential new approach for acne vulgaris care
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/98b56707c63147eeaff275218923639a
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Red Seaweed-Derived Compounds as a Potential New Approach for Acne Vulgaris Care

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