ADJUVANT EFFECT OF TUBULAR IMMUNOSTIMULATING COMPLEXES MODIFIED BY ECHINOCHROME A, TOWARDS A PORE PROTEIN FROM YERSINIA PSEUDOTUBERCULOSIS
Abstract. We investigated immunogenic properties of vaccine constructs based on lipid-saponin tubular immunostimulating complexes (TI-complexes), and an individual antigen, i.e., monomeric and trimeric forms of porin isolated from Yersinia pseudotuberculosis. An opportunity of enhanced imm...
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| Autores principales: | , , , , , , |
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| Formato: | article |
| Lenguaje: | RU |
| Publicado: |
SPb RAACI
2014
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/98b8d0f42c384de8a261a1f9f73727d1 |
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| Sumario: | Abstract. We investigated immunogenic properties of vaccine constructs based on lipid-saponin tubular immunostimulating complexes (TI-complexes), and an individual antigen, i.e., monomeric and trimeric forms of porin isolated from Yersinia pseudotuberculosis. An opportunity of enhanced immune response to TI-embedded porin was shown upon addition of echinochrome A (ECA) from sea urchin Scaphechinus mirabilis to TI-complexes. Immunization of mice with such a vaccine preparation results into a more intense specific humoral immune response to monomeric and trimeric forms of porin. (Med. Immunol., 2011, vol. 13, N 2-3, pp 139-144) |
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