ADJUVANT EFFECT OF TUBULAR IMMUNOSTIMULATING COMPLEXES MODIFIED BY ECHINOCHROME A, TOWARDS A PORE PROTEIN FROM YERSINIA PSEUDOTUBERCULOSIS

ADJUVANT EFFECT OF TUBULAR IMMUNOSTIMULATING COMPLEXES MODIFIED BY ECHINOCHROME A, TOWARDS A PORE PROTEIN FROM YERSINIA PSEUDOTUBERCULOSIS

Abstract. We investigated immunogenic properties of vaccine constructs based on lipid-saponin tubular immunostimulating  complexes  (TI-complexes),  and  an  individual  antigen,  i.e.,  monomeric  and  trimeric forms of porin isolated from Yersinia pseudotuberculosis. An opportunity of enhanced imm...

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Bibliographic Details
Main Authors: A. V. Tsybulsky, A. M. Popov, O. Yu. Portnyagina, A. A. Artyukov, N. M. Sanina, A. N. Mazeyka, E. Y. Kostetsky
Format: article
Language:RU
Published: SPb RAACI 2014
Subjects:
adjuvants
iskom
ti complexes
subunit antigen
porin
humoral immune response
echinochrome
Immunologic diseases. Allergy
RC581-607
Online Access:https://doaj.org/article/98b8d0f42c384de8a261a1f9f73727d1
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Summary:Abstract. We investigated immunogenic properties of vaccine constructs based on lipid-saponin tubular immunostimulating  complexes  (TI-complexes),  and  an  individual  antigen,  i.e.,  monomeric  and  trimeric forms of porin isolated from Yersinia pseudotuberculosis. An opportunity of enhanced immune response to TI-embedded porin was shown upon addition of echinochrome A (ECA) from sea urchin Scaphechinus mirabilis to TI-complexes. Immunization of mice with such a vaccine preparation results into a more intense specific humoral immune response to monomeric and trimeric forms of porin. (Med. Immunol., 2011, vol. 13, N 2-3, pp 139-144)

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