ADJUVANT EFFECT OF TUBULAR IMMUNOSTIMULATING COMPLEXES MODIFIED BY ECHINOCHROME A, TOWARDS A PORE PROTEIN FROM YERSINIA PSEUDOTUBERCULOSIS

Abstract. We investigated immunogenic properties of vaccine constructs based on lipid-saponin tubular immunostimulating  complexes  (TI-complexes),  and  an  individual  antigen,  i.e.,  monomeric  and  trimeric forms of porin isolated from Yersinia pseudotuberculosis. An opportunity of enhanced imm...

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Autores principales: A. V. Tsybulsky, A. M. Popov, O. Yu. Portnyagina, A. A. Artyukov, N. M. Sanina, A. N. Mazeyka, E. Y. Kostetsky
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Lenguaje:RU
Publicado: SPb RAACI 2014
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Acceso en línea:https://doaj.org/article/98b8d0f42c384de8a261a1f9f73727d1
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spelling oai:doaj.org-article:98b8d0f42c384de8a261a1f9f73727d12021-11-18T08:03:42ZADJUVANT EFFECT OF TUBULAR IMMUNOSTIMULATING COMPLEXES MODIFIED BY ECHINOCHROME A, TOWARDS A PORE PROTEIN FROM YERSINIA PSEUDOTUBERCULOSIS1563-06252313-741X10.15789/1563-0625-2011-2-3-139-144https://doaj.org/article/98b8d0f42c384de8a261a1f9f73727d12014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/521https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. We investigated immunogenic properties of vaccine constructs based on lipid-saponin tubular immunostimulating  complexes  (TI-complexes),  and  an  individual  antigen,  i.e.,  monomeric  and  trimeric forms of porin isolated from Yersinia pseudotuberculosis. An opportunity of enhanced immune response to TI-embedded porin was shown upon addition of echinochrome A (ECA) from sea urchin Scaphechinus mirabilis to TI-complexes. Immunization of mice with such a vaccine preparation results into a more intense specific humoral immune response to monomeric and trimeric forms of porin. (Med. Immunol., 2011, vol. 13, N 2-3, pp 139-144)A. V. TsybulskyA. M. PopovO. Yu. PortnyaginaA. A. ArtyukovN. M. SaninaA. N. MazeykaE. Y. KostetskySPb RAACIarticleadjuvantsiskomti complexessubunit antigenporinhumoral immune responseechinochromeImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 13, Iss 2-3, Pp 139-144 (2014)
institution DOAJ
collection DOAJ
language RU
topic adjuvants
iskom
ti complexes
subunit antigen
porin
humoral immune response
echinochrome
Immunologic diseases. Allergy
RC581-607
spellingShingle adjuvants
iskom
ti complexes
subunit antigen
porin
humoral immune response
echinochrome
Immunologic diseases. Allergy
RC581-607
A. V. Tsybulsky
A. M. Popov
O. Yu. Portnyagina
A. A. Artyukov
N. M. Sanina
A. N. Mazeyka
E. Y. Kostetsky
ADJUVANT EFFECT OF TUBULAR IMMUNOSTIMULATING COMPLEXES MODIFIED BY ECHINOCHROME A, TOWARDS A PORE PROTEIN FROM YERSINIA PSEUDOTUBERCULOSIS
description Abstract. We investigated immunogenic properties of vaccine constructs based on lipid-saponin tubular immunostimulating  complexes  (TI-complexes),  and  an  individual  antigen,  i.e.,  monomeric  and  trimeric forms of porin isolated from Yersinia pseudotuberculosis. An opportunity of enhanced immune response to TI-embedded porin was shown upon addition of echinochrome A (ECA) from sea urchin Scaphechinus mirabilis to TI-complexes. Immunization of mice with such a vaccine preparation results into a more intense specific humoral immune response to monomeric and trimeric forms of porin. (Med. Immunol., 2011, vol. 13, N 2-3, pp 139-144)
format article
author A. V. Tsybulsky
A. M. Popov
O. Yu. Portnyagina
A. A. Artyukov
N. M. Sanina
A. N. Mazeyka
E. Y. Kostetsky
author_facet A. V. Tsybulsky
A. M. Popov
O. Yu. Portnyagina
A. A. Artyukov
N. M. Sanina
A. N. Mazeyka
E. Y. Kostetsky
author_sort A. V. Tsybulsky
title ADJUVANT EFFECT OF TUBULAR IMMUNOSTIMULATING COMPLEXES MODIFIED BY ECHINOCHROME A, TOWARDS A PORE PROTEIN FROM YERSINIA PSEUDOTUBERCULOSIS
title_short ADJUVANT EFFECT OF TUBULAR IMMUNOSTIMULATING COMPLEXES MODIFIED BY ECHINOCHROME A, TOWARDS A PORE PROTEIN FROM YERSINIA PSEUDOTUBERCULOSIS
title_full ADJUVANT EFFECT OF TUBULAR IMMUNOSTIMULATING COMPLEXES MODIFIED BY ECHINOCHROME A, TOWARDS A PORE PROTEIN FROM YERSINIA PSEUDOTUBERCULOSIS
title_fullStr ADJUVANT EFFECT OF TUBULAR IMMUNOSTIMULATING COMPLEXES MODIFIED BY ECHINOCHROME A, TOWARDS A PORE PROTEIN FROM YERSINIA PSEUDOTUBERCULOSIS
title_full_unstemmed ADJUVANT EFFECT OF TUBULAR IMMUNOSTIMULATING COMPLEXES MODIFIED BY ECHINOCHROME A, TOWARDS A PORE PROTEIN FROM YERSINIA PSEUDOTUBERCULOSIS
title_sort adjuvant effect of tubular immunostimulating complexes modified by echinochrome a, towards a pore protein from yersinia pseudotuberculosis
publisher SPb RAACI
publishDate 2014
url https://doaj.org/article/98b8d0f42c384de8a261a1f9f73727d1
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