ADJUVANT EFFECT OF TUBULAR IMMUNOSTIMULATING COMPLEXES MODIFIED BY ECHINOCHROME A, TOWARDS A PORE PROTEIN FROM YERSINIA PSEUDOTUBERCULOSIS

Abstract. We investigated immunogenic properties of vaccine constructs based on lipid-saponin tubular immunostimulating complexes (TI-complexes), and an individual antigen, i.e., monomeric and trimeric forms of porin isolated from Yersinia pseudotuberculosis. An opportunity of enhanced imm...

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Auteurs principaux:	A. V. Tsybulsky, A. M. Popov, O. Yu. Portnyagina, A. A. Artyukov, N. M. Sanina, A. N. Mazeyka, E. Y. Kostetsky
Format:	article
Langue:	RU
Publié:	SPb RAACI 2014
Sujets:	adjuvants iskom ti complexes subunit antigen porin humoral immune response echinochrome Immunologic diseases. Allergy RC581-607
Accès en ligne:	https://doaj.org/article/98b8d0f42c384de8a261a1f9f73727d1
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id	oai:doaj.org-article:98b8d0f42c384de8a261a1f9f73727d1
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spelling	oai:doaj.org-article:98b8d0f42c384de8a261a1f9f73727d12021-11-18T08:03:42ZADJUVANT EFFECT OF TUBULAR IMMUNOSTIMULATING COMPLEXES MODIFIED BY ECHINOCHROME A, TOWARDS A PORE PROTEIN FROM YERSINIA PSEUDOTUBERCULOSIS1563-06252313-741X10.15789/1563-0625-2011-2-3-139-144https://doaj.org/article/98b8d0f42c384de8a261a1f9f73727d12014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/521https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. We investigated immunogenic properties of vaccine constructs based on lipid-saponin tubular immunostimulating complexes (TI-complexes), and an individual antigen, i.e., monomeric and trimeric forms of porin isolated from Yersinia pseudotuberculosis. An opportunity of enhanced immune response to TI-embedded porin was shown upon addition of echinochrome A (ECA) from sea urchin Scaphechinus mirabilis to TI-complexes. Immunization of mice with such a vaccine preparation results into a more intense specific humoral immune response to monomeric and trimeric forms of porin. (Med. Immunol., 2011, vol. 13, N 2-3, pp 139-144)A. V. TsybulskyA. M. PopovO. Yu. PortnyaginaA. A. ArtyukovN. M. SaninaA. N. MazeykaE. Y. KostetskySPb RAACIarticleadjuvantsiskomti complexessubunit antigenporinhumoral immune responseechinochromeImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 13, Iss 2-3, Pp 139-144 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	adjuvants iskom ti complexes subunit antigen porin humoral immune response echinochrome Immunologic diseases. Allergy RC581-607
spellingShingle	adjuvants iskom ti complexes subunit antigen porin humoral immune response echinochrome Immunologic diseases. Allergy RC581-607 A. V. Tsybulsky A. M. Popov O. Yu. Portnyagina A. A. Artyukov N. M. Sanina A. N. Mazeyka E. Y. Kostetsky ADJUVANT EFFECT OF TUBULAR IMMUNOSTIMULATING COMPLEXES MODIFIED BY ECHINOCHROME A, TOWARDS A PORE PROTEIN FROM YERSINIA PSEUDOTUBERCULOSIS
description	Abstract. We investigated immunogenic properties of vaccine constructs based on lipid-saponin tubular immunostimulating complexes (TI-complexes), and an individual antigen, i.e., monomeric and trimeric forms of porin isolated from Yersinia pseudotuberculosis. An opportunity of enhanced immune response to TI-embedded porin was shown upon addition of echinochrome A (ECA) from sea urchin Scaphechinus mirabilis to TI-complexes. Immunization of mice with such a vaccine preparation results into a more intense specific humoral immune response to monomeric and trimeric forms of porin. (Med. Immunol., 2011, vol. 13, N 2-3, pp 139-144)
format	article
author	A. V. Tsybulsky A. M. Popov O. Yu. Portnyagina A. A. Artyukov N. M. Sanina A. N. Mazeyka E. Y. Kostetsky
author_facet	A. V. Tsybulsky A. M. Popov O. Yu. Portnyagina A. A. Artyukov N. M. Sanina A. N. Mazeyka E. Y. Kostetsky
author_sort	A. V. Tsybulsky
title	ADJUVANT EFFECT OF TUBULAR IMMUNOSTIMULATING COMPLEXES MODIFIED BY ECHINOCHROME A, TOWARDS A PORE PROTEIN FROM YERSINIA PSEUDOTUBERCULOSIS
title_short	ADJUVANT EFFECT OF TUBULAR IMMUNOSTIMULATING COMPLEXES MODIFIED BY ECHINOCHROME A, TOWARDS A PORE PROTEIN FROM YERSINIA PSEUDOTUBERCULOSIS
title_full	ADJUVANT EFFECT OF TUBULAR IMMUNOSTIMULATING COMPLEXES MODIFIED BY ECHINOCHROME A, TOWARDS A PORE PROTEIN FROM YERSINIA PSEUDOTUBERCULOSIS
title_fullStr	ADJUVANT EFFECT OF TUBULAR IMMUNOSTIMULATING COMPLEXES MODIFIED BY ECHINOCHROME A, TOWARDS A PORE PROTEIN FROM YERSINIA PSEUDOTUBERCULOSIS
title_full_unstemmed	ADJUVANT EFFECT OF TUBULAR IMMUNOSTIMULATING COMPLEXES MODIFIED BY ECHINOCHROME A, TOWARDS A PORE PROTEIN FROM YERSINIA PSEUDOTUBERCULOSIS
title_sort	adjuvant effect of tubular immunostimulating complexes modified by echinochrome a, towards a pore protein from yersinia pseudotuberculosis
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/98b8d0f42c384de8a261a1f9f73727d1
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_version_	1718422494931582976

ADJUVANT EFFECT OF TUBULAR IMMUNOSTIMULATING COMPLEXES MODIFIED BY ECHINOCHROME A, TOWARDS A PORE PROTEIN FROM YERSINIA PSEUDOTUBERCULOSIS

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