EXPRESSION OF FoxP3 TRANSCRIPTION FACTOR IN BRONCHIAL ASTHMA

Forty-two patients with allergic bronchial asthma (ABA) forty persons with non-allergic bronchial asthma (NABA), and 47 healthy controls were involved into the study. Expression of FoxP3 mRNA was analyzed by RT-PCR. In patients with bronchial asthma (ABA and NABA) we have revealed a significant decr...

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Autores principales:	A. V. Eremeeva, L. N. Sorokina, V. N. Mineev, V. V. Lim, M. A. Nyoma, V. I. Trofimov
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2016
Materias:	bronchial asthma transcription factors foxp3 mononuclears Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/98bbe656b4324a74a0c365c21ebfb32f
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spelling	oai:doaj.org-article:98bbe656b4324a74a0c365c21ebfb32f2021-11-18T08:03:45ZEXPRESSION OF FoxP3 TRANSCRIPTION FACTOR IN BRONCHIAL ASTHMA1563-06252313-741X10.15789/1563-0625-2016-4-373-378https://doaj.org/article/98bbe656b4324a74a0c365c21ebfb32f2016-08-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/1060https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XForty-two patients with allergic bronchial asthma (ABA) forty persons with non-allergic bronchial asthma (NABA), and 47 healthy controls were involved into the study. Expression of FoxP3 mRNA was analyzed by RT-PCR. In patients with bronchial asthma (ABA and NABA) we have revealed a significant decrease in FoxP3 mRNA expression levels, in comparison with control group. The patients with severe BA exhibited lowest levels of the FoxP3 mRNA expression as compared with other groups.We revealed a decreased FoxP3 mRNA expression in mononuclear cells from peripheral blood, and an increased IL-17 level in blood serum of patients with bronchial asthma. These results may be considered a manifestation of serious inflammatory process. Probably, the data may reflect a disregulated expression of FoxP3 transcription factor. Therefore, we may assume a key role of FoxP3 for regulation of inflammatory activity in bronchial asthma.A. V. EremeevaL. N. SorokinaV. N. MineevV. V. LimM. A. NyomaV. I. TrofimovSPb RAACIarticlebronchial asthmatranscription factorsfoxp3mononuclearsImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 18, Iss 4, Pp 373-378 (2016)
institution	DOAJ
collection	DOAJ
language	RU
topic	bronchial asthma transcription factors foxp3 mononuclears Immunologic diseases. Allergy RC581-607
spellingShingle	bronchial asthma transcription factors foxp3 mononuclears Immunologic diseases. Allergy RC581-607 A. V. Eremeeva L. N. Sorokina V. N. Mineev V. V. Lim M. A. Nyoma V. I. Trofimov EXPRESSION OF FoxP3 TRANSCRIPTION FACTOR IN BRONCHIAL ASTHMA
description	Forty-two patients with allergic bronchial asthma (ABA) forty persons with non-allergic bronchial asthma (NABA), and 47 healthy controls were involved into the study. Expression of FoxP3 mRNA was analyzed by RT-PCR. In patients with bronchial asthma (ABA and NABA) we have revealed a significant decrease in FoxP3 mRNA expression levels, in comparison with control group. The patients with severe BA exhibited lowest levels of the FoxP3 mRNA expression as compared with other groups.We revealed a decreased FoxP3 mRNA expression in mononuclear cells from peripheral blood, and an increased IL-17 level in blood serum of patients with bronchial asthma. These results may be considered a manifestation of serious inflammatory process. Probably, the data may reflect a disregulated expression of FoxP3 transcription factor. Therefore, we may assume a key role of FoxP3 for regulation of inflammatory activity in bronchial asthma.
format	article
author	A. V. Eremeeva L. N. Sorokina V. N. Mineev V. V. Lim M. A. Nyoma V. I. Trofimov
author_facet	A. V. Eremeeva L. N. Sorokina V. N. Mineev V. V. Lim M. A. Nyoma V. I. Trofimov
author_sort	A. V. Eremeeva
title	EXPRESSION OF FoxP3 TRANSCRIPTION FACTOR IN BRONCHIAL ASTHMA
title_short	EXPRESSION OF FoxP3 TRANSCRIPTION FACTOR IN BRONCHIAL ASTHMA
title_full	EXPRESSION OF FoxP3 TRANSCRIPTION FACTOR IN BRONCHIAL ASTHMA
title_fullStr	EXPRESSION OF FoxP3 TRANSCRIPTION FACTOR IN BRONCHIAL ASTHMA
title_full_unstemmed	EXPRESSION OF FoxP3 TRANSCRIPTION FACTOR IN BRONCHIAL ASTHMA
title_sort	expression of foxp3 transcription factor in bronchial asthma
publisher	SPb RAACI
publishDate	2016
url	https://doaj.org/article/98bbe656b4324a74a0c365c21ebfb32f
work_keys_str_mv	AT averemeeva expressionoffoxp3transcriptionfactorinbronchialasthma AT lnsorokina expressionoffoxp3transcriptionfactorinbronchialasthma AT vnmineev expressionoffoxp3transcriptionfactorinbronchialasthma AT vvlim expressionoffoxp3transcriptionfactorinbronchialasthma AT manyoma expressionoffoxp3transcriptionfactorinbronchialasthma AT vitrofimov expressionoffoxp3transcriptionfactorinbronchialasthma
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EXPRESSION OF FoxP3 TRANSCRIPTION FACTOR IN BRONCHIAL ASTHMA

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