Treatment of natural mammary gland tumors in canines and felines using gold nanorods-assisted plasmonic photothermal therapy to induce tumor apoptosis

Moustafa R K Ali,1 Ibrahim M Ibrahim,2,&dagger; Hala R Ali,2,3 Salah A Selim,2 Mostafa A El-Sayed1,4 1School of Chemistry and Biochemistry, Georgia Institute of Technology, and Laser Dynamics Laboratory, Atlanta, GA, USA; 2Department of Veterinary Medicine, Cairo University, Giza, Cairo, Egypt;...

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Autores principales:	Ali MRK, Ibrahim IM, Ali HR, Selim SA, El-Sayed MA
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Gold nanorods (AuNRs) Natural mammary tumors Plasmonic photothermal therapy (PPTT) Canine Feline Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/98bcf2d57c8c4ec9b755e45e451450cc
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spelling	oai:doaj.org-article:98bcf2d57c8c4ec9b755e45e451450cc2021-12-02T04:27:08ZTreatment of natural mammary gland tumors in canines and felines using gold nanorods-assisted plasmonic photothermal therapy to induce tumor apoptosis1178-2013https://doaj.org/article/98bcf2d57c8c4ec9b755e45e451450cc2016-09-01T00:00:00Zhttps://www.dovepress.com/treatment-of-natural-mammary-gland-tumors-in-canines-and-felines-using-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Moustafa R K Ali,1 Ibrahim M Ibrahim,2,&dagger; Hala R Ali,2,3 Salah A Selim,2 Mostafa A El-Sayed1,4 1School of Chemistry and Biochemistry, Georgia Institute of Technology, and Laser Dynamics Laboratory, Atlanta, GA, USA; 2Department of Veterinary Medicine, Cairo University, Giza, Cairo, Egypt; 3Department of Bacteriology and Immunology, Animal Health Research Institute (AHRI), Dokki, Giza, Egypt; 4School of Chemistry, King Abdul Aziz University, Jeddah, Saudi Arabia &dagger;Ibrahim M Ibrahim passed away on August 23, 2015 Abstract: Plasmonic photothermal therapy (PPTT) is a cancer therapy in which gold nanorods are injected at the site of a tumor before near-infrared light is transiently applied to the tumor causing localized cell death. Previously, PPTT studies have been carried out on xenograft mice models. Herein, we report a study showing the feasibility of PPTT as applied to natural tumors in the mammary glands of dogs and cats, which more realistically represent their human equivalents at the molecular level. We optimized a regime of three low PPTT doses at 2-week intervals that ablated tumors mainly via apoptosis in 13 natural mammary gland tumors from seven animals. Histopathology, X-ray, blood profiles, and comprehensive examinations were used for both the diagnosis and the evaluation of tumor statuses before and after treatment. Histopathology results showed an obvious reduction in the cancer grade shortly after the first treatment and a complete regression after the third treatment. Blood tests showed no obvious change in liver and kidney functions. Similarly, X-ray diffraction showed no metastasis after 1 year of treatment. In conclusion, our study suggests the feasibility of applying the gold nanorods-PPTT on natural tumors in dogs and cats without any relapse or toxicity effects after 1 year of treatment. Keywords: gold nanorods, natural mammary tumors, plasmonic photothermal therapy, canine, felineAli MRKIbrahim IMAli HRSelim SAEl-Sayed MADove Medical PressarticleGold nanorods (AuNRs)Natural mammary tumorsPlasmonic photothermal therapy (PPTT)CanineFelineMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 11, Pp 4849-4863 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Gold nanorods (AuNRs) Natural mammary tumors Plasmonic photothermal therapy (PPTT) Canine Feline Medicine (General) R5-920
spellingShingle	Gold nanorods (AuNRs) Natural mammary tumors Plasmonic photothermal therapy (PPTT) Canine Feline Medicine (General) R5-920 Ali MRK Ibrahim IM Ali HR Selim SA El-Sayed MA Treatment of natural mammary gland tumors in canines and felines using gold nanorods-assisted plasmonic photothermal therapy to induce tumor apoptosis
description	Moustafa R K Ali,1 Ibrahim M Ibrahim,2,&dagger; Hala R Ali,2,3 Salah A Selim,2 Mostafa A El-Sayed1,4 1School of Chemistry and Biochemistry, Georgia Institute of Technology, and Laser Dynamics Laboratory, Atlanta, GA, USA; 2Department of Veterinary Medicine, Cairo University, Giza, Cairo, Egypt; 3Department of Bacteriology and Immunology, Animal Health Research Institute (AHRI), Dokki, Giza, Egypt; 4School of Chemistry, King Abdul Aziz University, Jeddah, Saudi Arabia &dagger;Ibrahim M Ibrahim passed away on August 23, 2015 Abstract: Plasmonic photothermal therapy (PPTT) is a cancer therapy in which gold nanorods are injected at the site of a tumor before near-infrared light is transiently applied to the tumor causing localized cell death. Previously, PPTT studies have been carried out on xenograft mice models. Herein, we report a study showing the feasibility of PPTT as applied to natural tumors in the mammary glands of dogs and cats, which more realistically represent their human equivalents at the molecular level. We optimized a regime of three low PPTT doses at 2-week intervals that ablated tumors mainly via apoptosis in 13 natural mammary gland tumors from seven animals. Histopathology, X-ray, blood profiles, and comprehensive examinations were used for both the diagnosis and the evaluation of tumor statuses before and after treatment. Histopathology results showed an obvious reduction in the cancer grade shortly after the first treatment and a complete regression after the third treatment. Blood tests showed no obvious change in liver and kidney functions. Similarly, X-ray diffraction showed no metastasis after 1 year of treatment. In conclusion, our study suggests the feasibility of applying the gold nanorods-PPTT on natural tumors in dogs and cats without any relapse or toxicity effects after 1 year of treatment. Keywords: gold nanorods, natural mammary tumors, plasmonic photothermal therapy, canine, feline
format	article
author	Ali MRK Ibrahim IM Ali HR Selim SA El-Sayed MA
author_facet	Ali MRK Ibrahim IM Ali HR Selim SA El-Sayed MA
author_sort	Ali MRK
title	Treatment of natural mammary gland tumors in canines and felines using gold nanorods-assisted plasmonic photothermal therapy to induce tumor apoptosis
title_short	Treatment of natural mammary gland tumors in canines and felines using gold nanorods-assisted plasmonic photothermal therapy to induce tumor apoptosis
title_full	Treatment of natural mammary gland tumors in canines and felines using gold nanorods-assisted plasmonic photothermal therapy to induce tumor apoptosis
title_fullStr	Treatment of natural mammary gland tumors in canines and felines using gold nanorods-assisted plasmonic photothermal therapy to induce tumor apoptosis
title_full_unstemmed	Treatment of natural mammary gland tumors in canines and felines using gold nanorods-assisted plasmonic photothermal therapy to induce tumor apoptosis
title_sort	treatment of natural mammary gland tumors in canines and felines using gold nanorods-assisted plasmonic photothermal therapy to induce tumor apoptosis
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/98bcf2d57c8c4ec9b755e45e451450cc
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Treatment of natural mammary gland tumors in canines and felines using gold nanorods-assisted plasmonic photothermal therapy to induce tumor apoptosis

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