Comparison of effects of different dietary interventions on cognitive function in Alzheimer’s disease: protocol for systematic review and network meta-analysis

Introduction Alzheimer’s disease (AD) is the most common neurodegenerative disease and is characterised by cognitive impairment. Non-pharmacological treatments such as diet therapy have been widely investigated in studies on AD. Given the synergistic effects of nutrients present in foods, considerin...

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Autores principales:	Lili Chen, Xinhua Xu, Huizhen Cao
Formato:	article
Lenguaje:	EN
Publicado:	BMJ Publishing Group 2021
Materias:	Medicine R
Acceso en línea:	https://doaj.org/article/98bec532666349eab1a1bf13c87c33c6
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spelling	oai:doaj.org-article:98bec532666349eab1a1bf13c87c33c62021-11-18T16:30:05ZComparison of effects of different dietary interventions on cognitive function in Alzheimer’s disease: protocol for systematic review and network meta-analysis10.1136/bmjopen-2020-0429972044-6055https://doaj.org/article/98bec532666349eab1a1bf13c87c33c62021-01-01T00:00:00Zhttps://bmjopen.bmj.com/content/11/1/e042997.fullhttps://doaj.org/toc/2044-6055Introduction Alzheimer’s disease (AD) is the most common neurodegenerative disease and is characterised by cognitive impairment. Non-pharmacological treatments such as diet therapy have been widely investigated in studies on AD. Given the synergistic effects of nutrients present in foods, considering overall dietary composition rather than focusing on a single nutrient may be more useful for evaluating the relationship between diet and AD cognition. The present study aimed to assess the efficacy of different dietary interventions (eg, ketogenic and Mediterranean diets) on cognitive function in patients with AD in a systematic review and pairwise and network meta-analyses of randomised controlled trials or clinical trials.Methods and analysis Two reviewers will independently conduct searches of PubMed, Cochrane Central Register of Controlled Trials, Embase, CINAHL, PsycINFO and China National Knowledge Infrastructure databases. Data will be extracted from selected studies and risk of bias will be assessed using the revised Cochrane risk-of-bias tool, and evidence quality will be assessed according to the Grading of Recommendations, Assessment, Development and Evaluation framework. The primary outcome of interest is cognitive function in patients with AD; secondary outcomes include biochemical biomarkers of AD and oxidative stress and/or inﬂammatory biomarkers in cerebrospinal fluid or plasma. For each outcome, random-effects pairwise and network meta-analyses will be carried out to determine the pooled relative effect of each intervention relative to every other intervention.Ethics and dissemination As this study is based solely on published literature, no ethics approval is required. The research will be published in a peer-reviewed journal.Lili ChenXinhua XuHuizhen CaoBMJ Publishing GrouparticleMedicineRENBMJ Open, Vol 11, Iss 1 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R
spellingShingle	Medicine R Lili Chen Xinhua Xu Huizhen Cao Comparison of effects of different dietary interventions on cognitive function in Alzheimer’s disease: protocol for systematic review and network meta-analysis
description	Introduction Alzheimer’s disease (AD) is the most common neurodegenerative disease and is characterised by cognitive impairment. Non-pharmacological treatments such as diet therapy have been widely investigated in studies on AD. Given the synergistic effects of nutrients present in foods, considering overall dietary composition rather than focusing on a single nutrient may be more useful for evaluating the relationship between diet and AD cognition. The present study aimed to assess the efficacy of different dietary interventions (eg, ketogenic and Mediterranean diets) on cognitive function in patients with AD in a systematic review and pairwise and network meta-analyses of randomised controlled trials or clinical trials.Methods and analysis Two reviewers will independently conduct searches of PubMed, Cochrane Central Register of Controlled Trials, Embase, CINAHL, PsycINFO and China National Knowledge Infrastructure databases. Data will be extracted from selected studies and risk of bias will be assessed using the revised Cochrane risk-of-bias tool, and evidence quality will be assessed according to the Grading of Recommendations, Assessment, Development and Evaluation framework. The primary outcome of interest is cognitive function in patients with AD; secondary outcomes include biochemical biomarkers of AD and oxidative stress and/or inﬂammatory biomarkers in cerebrospinal fluid or plasma. For each outcome, random-effects pairwise and network meta-analyses will be carried out to determine the pooled relative effect of each intervention relative to every other intervention.Ethics and dissemination As this study is based solely on published literature, no ethics approval is required. The research will be published in a peer-reviewed journal.
format	article
author	Lili Chen Xinhua Xu Huizhen Cao
author_facet	Lili Chen Xinhua Xu Huizhen Cao
author_sort	Lili Chen
title	Comparison of effects of different dietary interventions on cognitive function in Alzheimer’s disease: protocol for systematic review and network meta-analysis
title_short	Comparison of effects of different dietary interventions on cognitive function in Alzheimer’s disease: protocol for systematic review and network meta-analysis
title_full	Comparison of effects of different dietary interventions on cognitive function in Alzheimer’s disease: protocol for systematic review and network meta-analysis
title_fullStr	Comparison of effects of different dietary interventions on cognitive function in Alzheimer’s disease: protocol for systematic review and network meta-analysis
title_full_unstemmed	Comparison of effects of different dietary interventions on cognitive function in Alzheimer’s disease: protocol for systematic review and network meta-analysis
title_sort	comparison of effects of different dietary interventions on cognitive function in alzheimer’s disease: protocol for systematic review and network meta-analysis
publisher	BMJ Publishing Group
publishDate	2021
url	https://doaj.org/article/98bec532666349eab1a1bf13c87c33c6
work_keys_str_mv	AT lilichen comparisonofeffectsofdifferentdietaryinterventionsoncognitivefunctioninalzheimersdiseaseprotocolforsystematicreviewandnetworkmetaanalysis AT xinhuaxu comparisonofeffectsofdifferentdietaryinterventionsoncognitivefunctioninalzheimersdiseaseprotocolforsystematicreviewandnetworkmetaanalysis AT huizhencao comparisonofeffectsofdifferentdietaryinterventionsoncognitivefunctioninalzheimersdiseaseprotocolforsystematicreviewandnetworkmetaanalysis
_version_	1718420798599856128

Comparison of effects of different dietary interventions on cognitive function in Alzheimer’s disease: protocol for systematic review and network meta-analysis

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