Pandemic H1N1 influenza A viruses suppress immunogenic RIPK3-driven dendritic cell death

The differences in virus-host interactions resulting in distinct pathogenicity of seasonal and pandemic influenza A viruses (IAV) are not well understood. Here, the authors show that the hemagglutinin segment from pandemic, but not seasonal, IAV suppresses RIPK3-mediated dendritic cell death, thereb...

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Autores principales:	Boris M. Hartmann, Randy A. Albrecht, Elena Zaslavsky, German Nudelman, Hanna Pincas, Nada Marjanovic, Michael Schotsaert, Carles Martínez-Romero, Rafael Fenutria, Justin P. Ingram, Irene Ramos, Ana Fernandez-Sesma, Siddharth Balachandran, Adolfo García-Sastre, Stuart C. Sealfon
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/98c3812ea23a4a069550f62b6a56b07d
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spelling	oai:doaj.org-article:98c3812ea23a4a069550f62b6a56b07d2021-12-02T14:42:40ZPandemic H1N1 influenza A viruses suppress immunogenic RIPK3-driven dendritic cell death10.1038/s41467-017-02035-92041-1723https://doaj.org/article/98c3812ea23a4a069550f62b6a56b07d2017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02035-9https://doaj.org/toc/2041-1723The differences in virus-host interactions resulting in distinct pathogenicity of seasonal and pandemic influenza A viruses (IAV) are not well understood. Here, the authors show that the hemagglutinin segment from pandemic, but not seasonal, IAV suppresses RIPK3-mediated dendritic cell death, thereby reducing T cell activation.Boris M. HartmannRandy A. AlbrechtElena ZaslavskyGerman NudelmanHanna PincasNada MarjanovicMichael SchotsaertCarles Martínez-RomeroRafael FenutriaJustin P. IngramIrene RamosAna Fernandez-SesmaSiddharth BalachandranAdolfo García-SastreStuart C. SealfonNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Boris M. Hartmann Randy A. Albrecht Elena Zaslavsky German Nudelman Hanna Pincas Nada Marjanovic Michael Schotsaert Carles Martínez-Romero Rafael Fenutria Justin P. Ingram Irene Ramos Ana Fernandez-Sesma Siddharth Balachandran Adolfo García-Sastre Stuart C. Sealfon Pandemic H1N1 influenza A viruses suppress immunogenic RIPK3-driven dendritic cell death
description	The differences in virus-host interactions resulting in distinct pathogenicity of seasonal and pandemic influenza A viruses (IAV) are not well understood. Here, the authors show that the hemagglutinin segment from pandemic, but not seasonal, IAV suppresses RIPK3-mediated dendritic cell death, thereby reducing T cell activation.
format	article
author	Boris M. Hartmann Randy A. Albrecht Elena Zaslavsky German Nudelman Hanna Pincas Nada Marjanovic Michael Schotsaert Carles Martínez-Romero Rafael Fenutria Justin P. Ingram Irene Ramos Ana Fernandez-Sesma Siddharth Balachandran Adolfo García-Sastre Stuart C. Sealfon
author_facet	Boris M. Hartmann Randy A. Albrecht Elena Zaslavsky German Nudelman Hanna Pincas Nada Marjanovic Michael Schotsaert Carles Martínez-Romero Rafael Fenutria Justin P. Ingram Irene Ramos Ana Fernandez-Sesma Siddharth Balachandran Adolfo García-Sastre Stuart C. Sealfon
author_sort	Boris M. Hartmann
title	Pandemic H1N1 influenza A viruses suppress immunogenic RIPK3-driven dendritic cell death
title_short	Pandemic H1N1 influenza A viruses suppress immunogenic RIPK3-driven dendritic cell death
title_full	Pandemic H1N1 influenza A viruses suppress immunogenic RIPK3-driven dendritic cell death
title_fullStr	Pandemic H1N1 influenza A viruses suppress immunogenic RIPK3-driven dendritic cell death
title_full_unstemmed	Pandemic H1N1 influenza A viruses suppress immunogenic RIPK3-driven dendritic cell death
title_sort	pandemic h1n1 influenza a viruses suppress immunogenic ripk3-driven dendritic cell death
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/98c3812ea23a4a069550f62b6a56b07d
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Pandemic H1N1 influenza A viruses suppress immunogenic RIPK3-driven dendritic cell death

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