Serum endocan levels in women with restless legs syndrome

Kenan Celik,1 Mehmet A Cikrikcioglu,1 Gulistan Halac,2 Elif Kilic,3 Siddika Ayhan,3 Nihal Ozaras,4 Kemal Yildiz,5 Rabia S Yildiz,1 Mehmet Zorlu,1 Cumali Karatoprak,1 Mustafa Cakirca,1 Muharrem Kiskac1 1Department of Internal Medicine, 2Department of Neurology, 3Department of Biochemistry, 4Departme...

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Autores principales:	Celik K, Cikrikcioglu MA, Halac G, Kilic E, Ayhan S, Ozaras N, Yildiz K, Yildiz RS, Zorlu M, Karatoprak C, Cakirca M, Kiskac M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/98c862b34f9c49ddadbcc2bbe96c7b7f
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spelling	oai:doaj.org-article:98c862b34f9c49ddadbcc2bbe96c7b7f2021-12-02T08:08:55ZSerum endocan levels in women with restless legs syndrome1178-2021https://doaj.org/article/98c862b34f9c49ddadbcc2bbe96c7b7f2015-11-01T00:00:00Zhttps://www.dovepress.com/serum-endocan-levels-in-women-with-restless-legs-syndrome-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Kenan Celik,1 Mehmet A Cikrikcioglu,1 Gulistan Halac,2 Elif Kilic,3 Siddika Ayhan,3 Nihal Ozaras,4 Kemal Yildiz,5 Rabia S Yildiz,1 Mehmet Zorlu,1 Cumali Karatoprak,1 Mustafa Cakirca,1 Muharrem Kiskac1 1Department of Internal Medicine, 2Department of Neurology, 3Department of Biochemistry, 4Department of Physical Medicine and Rehabilitation, Medical Faculty, Bezmialem Vakif University, Fatih, 5Department of Internal Medicine, Private Medicana International Istanbul Hospital, Beylikdüzü, Istanbul, Turkey Background: Endocan is a recently introduced marker of endothelial dysfunction. The objective of this study was to compare serum endocan levels in patients with restless legs syndrome (RLS) and control subjects in order to elucidate whether RLS is associated with endothelial dysfunction. Methods: A total of 31 drug naïve female patients with RLS and 31 age- and BMI-matched women were included in the study. Patients with pathological or physiological conditions or with a history of medication use that could potentially influence endothelial functions were excluded, as well as those with alcohol or drug abuse history. The two groups were compared with routine blood tests and serum endocan levels. Results: Patients with RLS had lower serum endocan levels than the controls (P=0.037). There was a negative bivariate correlation between RLS severity score and serum endocan levels (r=-0.406, P=0.023). While white blood cell count was significantly higher in RLS group, 25-hydroxy vitamin D3, vitamin B12, transferrin saturation rate, and HDL-cholesterol were significantly lower. Creatininemia and diastolic blood pressure were also marginally insignificantly lower in RLS group. Due to the presence of differences between two groups in these variables, a linear regression analysis was performed that showed a positive association between endocan and creatininemia (β=0.310, P=0.022), and a negative association between endocan and RLS (β=-0.502, P<0.001). Conclusion: The results of this study seem to suggest that patients with RLS may have better endothelial functions when compared with the general population and that these patients may be better protected against atherosclerosis. Keywords: endocan, restless legs syndrome, RLS, atherosclerosis, endothelial Celik KCikrikcioglu MAHalac GKilic EAyhan SOzaras NYildiz KYildiz RSZorlu MKaratoprak CCakirca MKiskac MDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2015, Iss default, Pp 2919-2925 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Celik K Cikrikcioglu MA Halac G Kilic E Ayhan S Ozaras N Yildiz K Yildiz RS Zorlu M Karatoprak C Cakirca M Kiskac M Serum endocan levels in women with restless legs syndrome
description	Kenan Celik,1 Mehmet A Cikrikcioglu,1 Gulistan Halac,2 Elif Kilic,3 Siddika Ayhan,3 Nihal Ozaras,4 Kemal Yildiz,5 Rabia S Yildiz,1 Mehmet Zorlu,1 Cumali Karatoprak,1 Mustafa Cakirca,1 Muharrem Kiskac1 1Department of Internal Medicine, 2Department of Neurology, 3Department of Biochemistry, 4Department of Physical Medicine and Rehabilitation, Medical Faculty, Bezmialem Vakif University, Fatih, 5Department of Internal Medicine, Private Medicana International Istanbul Hospital, Beylikdüzü, Istanbul, Turkey Background: Endocan is a recently introduced marker of endothelial dysfunction. The objective of this study was to compare serum endocan levels in patients with restless legs syndrome (RLS) and control subjects in order to elucidate whether RLS is associated with endothelial dysfunction. Methods: A total of 31 drug naïve female patients with RLS and 31 age- and BMI-matched women were included in the study. Patients with pathological or physiological conditions or with a history of medication use that could potentially influence endothelial functions were excluded, as well as those with alcohol or drug abuse history. The two groups were compared with routine blood tests and serum endocan levels. Results: Patients with RLS had lower serum endocan levels than the controls (P=0.037). There was a negative bivariate correlation between RLS severity score and serum endocan levels (r=-0.406, P=0.023). While white blood cell count was significantly higher in RLS group, 25-hydroxy vitamin D3, vitamin B12, transferrin saturation rate, and HDL-cholesterol were significantly lower. Creatininemia and diastolic blood pressure were also marginally insignificantly lower in RLS group. Due to the presence of differences between two groups in these variables, a linear regression analysis was performed that showed a positive association between endocan and creatininemia (β=0.310, P=0.022), and a negative association between endocan and RLS (β=-0.502, P<0.001). Conclusion: The results of this study seem to suggest that patients with RLS may have better endothelial functions when compared with the general population and that these patients may be better protected against atherosclerosis. Keywords: endocan, restless legs syndrome, RLS, atherosclerosis, endothelial
format	article
author	Celik K Cikrikcioglu MA Halac G Kilic E Ayhan S Ozaras N Yildiz K Yildiz RS Zorlu M Karatoprak C Cakirca M Kiskac M
author_facet	Celik K Cikrikcioglu MA Halac G Kilic E Ayhan S Ozaras N Yildiz K Yildiz RS Zorlu M Karatoprak C Cakirca M Kiskac M
author_sort	Celik K
title	Serum endocan levels in women with restless legs syndrome
title_short	Serum endocan levels in women with restless legs syndrome
title_full	Serum endocan levels in women with restless legs syndrome
title_fullStr	Serum endocan levels in women with restless legs syndrome
title_full_unstemmed	Serum endocan levels in women with restless legs syndrome
title_sort	serum endocan levels in women with restless legs syndrome
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/98c862b34f9c49ddadbcc2bbe96c7b7f
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Serum endocan levels in women with restless legs syndrome

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