Matrix mechanical plasticity regulates cancer cell migration through confining microenvironments

In order to metastasize, cancer cells must migrate through basement membranes and dense stroma, and proteases are thought to be required due to the confining nature of these matrices. Here the authors use synthetic matrices to show that cells can migrate through confining matrices using force genera...

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Autores principales:	Katrina M. Wisdom, Kolade Adebowale, Julie Chang, Joanna Y. Lee, Sungmin Nam, Rajiv Desai, Ninna Struck Rossen, Marjan Rafat, Robert B. West, Louis Hodgson, Ovijit Chaudhuri
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/98c929b92b67496b9f803a21d27ece3c
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spelling	oai:doaj.org-article:98c929b92b67496b9f803a21d27ece3c2021-12-02T16:49:35ZMatrix mechanical plasticity regulates cancer cell migration through confining microenvironments10.1038/s41467-018-06641-z2041-1723https://doaj.org/article/98c929b92b67496b9f803a21d27ece3c2018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06641-zhttps://doaj.org/toc/2041-1723In order to metastasize, cancer cells must migrate through basement membranes and dense stroma, and proteases are thought to be required due to the confining nature of these matrices. Here the authors use synthetic matrices to show that cells can migrate through confining matrices using force generation alone, rather than protease degradation, if the matrices exhibit mechanical plasticity.Katrina M. WisdomKolade AdebowaleJulie ChangJoanna Y. LeeSungmin NamRajiv DesaiNinna Struck RossenMarjan RafatRobert B. WestLouis HodgsonOvijit ChaudhuriNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Katrina M. Wisdom Kolade Adebowale Julie Chang Joanna Y. Lee Sungmin Nam Rajiv Desai Ninna Struck Rossen Marjan Rafat Robert B. West Louis Hodgson Ovijit Chaudhuri Matrix mechanical plasticity regulates cancer cell migration through confining microenvironments
description	In order to metastasize, cancer cells must migrate through basement membranes and dense stroma, and proteases are thought to be required due to the confining nature of these matrices. Here the authors use synthetic matrices to show that cells can migrate through confining matrices using force generation alone, rather than protease degradation, if the matrices exhibit mechanical plasticity.
format	article
author	Katrina M. Wisdom Kolade Adebowale Julie Chang Joanna Y. Lee Sungmin Nam Rajiv Desai Ninna Struck Rossen Marjan Rafat Robert B. West Louis Hodgson Ovijit Chaudhuri
author_facet	Katrina M. Wisdom Kolade Adebowale Julie Chang Joanna Y. Lee Sungmin Nam Rajiv Desai Ninna Struck Rossen Marjan Rafat Robert B. West Louis Hodgson Ovijit Chaudhuri
author_sort	Katrina M. Wisdom
title	Matrix mechanical plasticity regulates cancer cell migration through confining microenvironments
title_short	Matrix mechanical plasticity regulates cancer cell migration through confining microenvironments
title_full	Matrix mechanical plasticity regulates cancer cell migration through confining microenvironments
title_fullStr	Matrix mechanical plasticity regulates cancer cell migration through confining microenvironments
title_full_unstemmed	Matrix mechanical plasticity regulates cancer cell migration through confining microenvironments
title_sort	matrix mechanical plasticity regulates cancer cell migration through confining microenvironments
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/98c929b92b67496b9f803a21d27ece3c
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Matrix mechanical plasticity regulates cancer cell migration through confining microenvironments

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